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The protein encoded by SEC61A1 belongs to the SECY/SEC61- alpha family. Additionally we are shipping Sec61 alpha 1 Subunit (S. Cerevisiae) Antibodies (49) and and many more products for this protein.
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Shows that inhibition of Sec61 by mycolactone drives rapid and broad translational reprogramming of a subset of genes involved in stress responses that is initially protective but ultimately leads to cell death
Unpicking the central dogma of molecular biology step-by-step identifies the Sec61 translocon as the target of anti-inflammatory activity of mycolactone, explaining why production of Sec61-dependent proteins (secretory, ER resident and membrane bound) is lost even though transcription and translation are unaffected.
The direct contribution of Sec61 to antigen cross-presentation, endosome-to-cytosol export, and endoplasmic reticulum-to-cytosol export.
The authors propose that the Sec61-IRE1alpha (show ERN1 Proteins) complex defines the extent of IRE1alpha (show ERN1 Proteins) activity and may determine cell fate decisions during endoplasmic reticulum stress conditions.
EPO (show EPO Proteins) (7q22) and SEC-61(7p11) emerged as new candidate genes susceptible to genetic losses with 57.7% deletions identified in regions on chromosome 7.
Tomography densities at subnanometer resolution revealed an intricate network of interactions between the ribosome, Sec61 and accessory translocon components that assist in protein transport, membrane insertion and maturation
The discovery of export-specific sec61 mutants and of mammalian ER-associated degradation (ERAD) substrates whose export is dependent on the 19S regulatory particle suggest that dismissal of a role of Sec61 in export may have been premature.
the effect of mycolactone on transmembrane protein biogenesis depends on how the nascent chain initially engages the Sec61 complex.
data provide definitive genetic evidence that Sec61 is the host receptor mediating the diverse immunomodulatory effects of mycolactone and identify Sec61 as a novel regulator of immune cell functions.
findings provide a mechanism by which mutations in SEC61A1 lead to an autosomal-dominant syndromic form of progressive chronic kidney disease; we highlight protein translocation defects across the endoplasmic reticulum membrane, the principal role of the SEC61 complex, as a contributory pathogenic mechanism for autosomal-dominant tubulo-interstitial kidney disease
Interaction of ribosomes and Sec62 (show TLOC1 Proteins) with the core Sec61 translocon is mutually exclusive.
SEC61A1 gene silencing inhibits co- and post-translational transport of presecretory proteins into endoplasmic reticulum.
Diabetes can bemapped to a point mutation in the Sec61a1 gene that encodes a His to Tyr (show TYR Proteins) substitution at amino acid 344.
A screen for mutations that affect habenular laterality led to the identification of the sec61a-like 1(sec61al1) gene.
The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits.
, protein transport protein SEC61 alpha subunit
, protein transport protein Sec61 subunit alpha
, protein transport protein Sec61 subunit alpha isoform 1
, sec61 homolog
, SEC61, alpha subunit
, sec61 alpha-1
, transport protein sec61 alpha subunit
, Sec61 alpha subunit homolog
, sec61 homologue
, Sec61 alpha 1 subunit (S. cerevisiae)
, Sec61 alpha form 1
, transport protein Sec61 alpha subunit
, Protein transport protein Sec61 subunit alpha
, protein transport protein Sec61 subunit alpha-like
, Sec61 alpha like 1
, protein transport protein Sec61 subunit alpha-like 1
, hypothetical protein