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The protein encoded by SCTR is a G protein-coupled receptor and belongs to the glucagon-VIP-secretin receptor family.
Showing 10 out of 69 products:
Human Polyclonal SCTR Primary Antibody for IHC, IHC (p) - ABIN4352443
Procino, Milano, Carmosino, Barbieri, Nicoletti, Li, Wess, Svelto: Combination of secretin and fluvastatin ameliorates the polyuria associated with X-linked nephrogenic diabetes insipidus in mice. in Kidney international 2014
elevated in (show SECR Antibodies)primary sclerosing cholangitis liver samples compared to healthy controls
Structure and Function of Cross-class Complexes of G Protein-coupled Secretin (show SECR Antibodies) and Angiotensin 1a Receptors.
Cysteine trapping identified charge-charge interactions between secretin (show SECR Antibodies) and secretin receptor residues in TM5, TM6, ECL2, and ECL3 domains.
Our findings indicate that SCTR suppresses the proliferation of normal breast cells, while the gene stimulates the proliferation and migration of cancer cells being downregulated by promoter methylation.
High SCTR expression is associated with liver metastases of pancreas neuroendocrine tumors.
Results suggest that Secretin (show SECR Antibodies) is a potent modulator of adipocyte functions, demonstrating overall a role in enhanced substrate cycling.
Taken together, we propose here that the down-regulatory effects of NRSF (show REST Antibodies) on hSCTR gene expression are mediated via its suppression on Sp1 (show PSG1 Antibodies)-mediated transactivation.
Data suggest that the interaction between secretin (show SECR Antibodies) peptide residue H1 and secretin receptor residue W274 is most compatible with a hydrophobic interaction.
binding and activity of a series of 11 truncated and lactam-constrained secretin (show SECR Antibodies)(5-27) analogues at the prototypic member of this family, the secretin receptor
results demonstrate that secretin (show SECR Antibodies) and/or the modulation of SCTR expression might have potential as a therapeutic tool in the treatment of cholangiocarcinoma
Knockout of SCTR results in defective aldosterone biosynthesis/release and altered sensitivity of ENaCs to amiloride.
Data show that upon heteromer formation with secretin receptor (SCTR), R137H, a nephrogenic diabetes insipidus (show AVPR2 Antibodies) (NDI (show AVPR2 Antibodies))-causing vasopressin (show AVP Antibodies) receptor 2 (AVPR2 (show AVPR2 Antibodies)) mutant that is defective in trafficking to cell surface, can functionally be rescued.
The secretin (show SECR Antibodies)/SR axis plays a key role in regulating the biliary contribution to cholestasis-induced hepatic fibrosis.
In vivo, osmotic stress up-regulates the SCTR gene in the kidney cortex and medulla of wild-type mice, but does not do so in NFAT5 (show NFAT5 Antibodies)(+/-) mice.
Animal studies demonstrate that secretin receptor (show GPR56 Antibodies) deficiency slightly, but significantly, prolongs incubation time in female but not male mice.
Despite similar food intake, SCTR(-/-) mice have less weight, less fat, less hyperleptinemia and better glucose/insulin (show INS Antibodies) tolerance on a high-fat diet, and less intestinal fatty acid absorption but similar energy expenditure and locomotor activity.
Immunohistochemical staining of the arcuate nucleus shows colocalization of Sctr with proopiomelanocortin (show POMC Antibodies) that provide proof of signals downstream to the paraventricular nucleus that lead to food intake reduction.
Secretin (show SECR Antibodies)-deficient mice exhibit decreased numbers of new neurons and increased apoptosis of progenitor cells in the dentate gyrus.
Findings identify SCT (show SECR Antibodies) and SCTR as novel elements of the ANGII osmoregulatory pathway in maintaining fluid balance in the body.
data indicate that secretin (show SECR Antibodies) exerts a direct action on pancreatic secretion through specific SEC-R coupled to the adenylate cyclase system
The protein encoded by this gene is a G protein-coupled receptor and belongs to the glucagon-VIP-secretin receptor family. It binds secretin which is the most potent regulator of pancreatic bicarbonate, electrolyte and volume secretion. Secretin and its receptor are suggested to be involved in pancreatic cancer and autism.
pancreatic secretin receptor