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SLPI encodes a secreted inhibitor which protects epithelial tissues from serine proteases.
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Mouse (Murine) SLPI ELISA Kit for Sandwich ELISA - ABIN424741
Mosedale, Kim, Brock, Roth, Wiltshire, Eaddy, Keele, Corty, Xie, Valdar, Watkins: Editor's Highlight: Candidate Risk Factors and Mechanisms for Tolvaptan-Induced Liver Injury Are Identified Using a Collaborative Cross Approach. in Toxicological sciences : an official journal of the Society of Toxicology 2017
Human SLPI ELISA Kit for Sandwich ELISA - ABIN414617
Olewicz-Gawlik, Trzybulska, Graniczna, Kuznar-Kaminska, Katulska, Batura-Gabryel, Frydrychowicz, Danczak-Pazdrowska, Mozer-Lisewska: Serum alarm antiproteases in systemic sclerosis patients. in Human immunology 2017
Together, these data support the clinical evaluation of dual angiogenic inhibition of the ALK1 (show ACVRL1 ELISA Kits) and VEGF (show VEGFA ELISA Kits) pathways in patients with advanced renal cell carcinoma (RCC (show XRCC1 ELISA Kits)) .
the patients with systemic sclerosis had significantly increased serum levels of SLPI in comparison with the rheumatoid arthritis patients and the healthy controls
gene expression profiling study based on microarray data for the three cell types identified a number of candidates, including LCP1 (show LCP1 ELISA Kits) and GLI (show GLI1 ELISA Kits), that could be key molecules in the mechanism of SLPI-induced cell migration
we show that SLPI acts as a key mediator in regulating the function of hepatic myeloid cells, to promote resolution responses through induction of MerTK (show MERTK ELISA Kits) expression within the resident macrophage population.
these data demonstrate increased anti-inflammatory activity of the SLPI-A16G protein compared with SLPI-WT in a murine model of pulmonary Pseudomonas infection
we demonstrated that the oncogenic effect of SLPI may be due to protection of growth factor progranulin (show GRN ELISA Kits) from enzymatic cleavage or suppression of castration-resistant prostate cancer (CRPC)cell apoptosis independent of anti-protease activity of SLPI. These findings implicate SLPI as a potential biomarker of resistance to AR inhibition and therapeutic target for CRPC treatment
Secretory leukocyte protease inhibitor mediates invasiveness of oral carcinoma cells.
The results indicate that SERPINE2 (show SERPINE2 ELISA Kits) and SLPI play a significant role in the development of papillary thyroid cancer and imply that the evaluation of serum concentrations of both anticoagulant molecules may be considered as additional marker for the differentiation of malignancies during the preoperative diagnosis of patients with thyroid gland tumors.
Bronchial epithelial cells have decreased SLPI expression in response to hypoxia.
Ongoing herpes simplex virus infection and resultant downregulation of local levels of SLPI may impart a greater susceptibility for keratinocytes to human papillomavirus type 16 infection through the host cell receptor annexin A2 (show ANXA2 ELISA Kits).
We demonstrate by silencing the SLPI gene, that SLPI negatively regulates human periodontal ligament cell expression of the pro-inflammatory cytokines IL-6 (show IL6 ELISA Kits) and MCP-1 (show CPT1B ELISA Kits).
MIF-2 (show HSPA5 ELISA Kits)/D-DT is an early response cytokine in the I/R injury repair of the proximal tubule, enhancing regeneration through SLPI- and ATF4 (show ATF4 ELISA Kits)-dependent mechanisms.
Slpi(-/-) mice had impaired collagen gene expression but animals demonstrated minimal reduction in lung fibrosis compared with wild-type animals. These data suggest that enhanced proteolysis does not further enhance TGF-beta (show TGFB1 ELISA Kits) activation, and inhibits sustained Col1alpha1, Col3alpha1, and Col4alpha1 gene expression following lung injury.
Data show that differentiative switches between bronchiolar progenitors and club cells are under the Nrf2 (show NFE2L2 ELISA Kits)-mediated control of SLPI and syndecan 4 (show SDC4 ELISA Kits).
study identifies a distinct immune response in SA characterized by a dysregulated IFN-gamma (show IFNG ELISA Kits)/SLPI axis that affects lung function.
Studied the function of Secretory Leukocyte Protease Inhibitor (SLPI) in odontoblast during mouse tooth development.
Data show that the expression of several genes encoding salivary antimicrobial proteins, such as secretory leukocyte peptidase inhibitor (SLPI), S100A8 (show S100A8 ELISA Kits), and lactotransferrin (show LTF ELISA Kits), was reduced due to myeloid differentiation dactor 88 (MyD88 (show MYD88 ELISA Kits)) deficiency.
a possible role for SLPI in enhancing the metastatic behavior of breast cancer cell line 4T1
These studies define an important role for SLPI in innate and adaptive immunity and offer new insight into strategies for the use of this naturally occurring molecule in the modulation of infectious and inflammatory diseases.
In experimental autoimmune encephalomyelitis, SLPI exerts potent pro-inflammatory actions by modulation of T-cell activity
This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes\; the protein is also thought to have broad-spectrum anti-biotic activity.
, WAP four-disulfide core domain protein 4
, mucus proteinase inhibitor
, protease inhibitor WAP4
, secretory leukocyte protease inhibitor (antileukoproteinase)
, seminal proteinase inhibitor
, secretory leukocyte protease inhibitor
, matrilin 4
, secretory leukocyte peptidase inhibitor