Secretory Leukocyte Peptidase Inhibitor Proteins (SLPI)

SLPI encodes a secreted inhibitor which protects epithelial tissues from serine proteases. Additionally we are shipping SLPI Antibodies (113) and SLPI Kits (27) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLPI 6590 P03973
SLPI 20568 P97430
Rat SLPI SLPI 84386  
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Top SLPI Proteins at

Showing 10 out of 17 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
Baculovirus infected Insect Cells Human His tag 100 μg 14 to 16 Days
Escherichia coli (E. coli) Please inquire GST tag Secretory Leukocyte Peptidase Inhibitor (SLPI) (AA 26-132), (full length) protein (GST tag) 50 μg 13 to 16 Days
Wheat germ Human GST tag 10 μg 11 to 12 Days
Escherichia coli (E. coli) Human His tag 50 μg 15 to 19 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
Escherichia coli (E. coli) Mouse Un-conjugated SDS-PAGE analysis of Mouse SLPI Protein. 100 μg 11 to 18 Days
Escherichia coli (E. coli) Mouse His tag,S tag 100 μg 15 to 18 Days
Yeast Wild boar His tag   1 mg 60 to 71 Days

SLPI Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Mouse (Murine) ,

More Proteins for Secretory Leukocyte Peptidase Inhibitor (SLPI) Interaction Partners

Human Secretory Leukocyte Peptidase Inhibitor (SLPI) interaction partners

  1. Low SLPI expression is associated with mammary carcinoma.

  2. Neutrophils and Activated Macrophages Control Mucosal Immunity by Proteolytic Cleavage of Antileukoproteinase.

  3. Study indicate that SLPI seems to be one of the important immunomodulatory proteins that provide local immune response in cervical mucosa.

  4. we investigated the biological effects of SLPI using Cell Counting Kit (CCK)-8, Annexin V/PI apoptosis assay and Caspase-Glo(R) 3/7 assay. The findings revealed that SLPI promoted apoptosis in the Leuk1 and WSU-HN4 cell lines. Mechanistic studies indicated that SLPI, at least in part, regulated cell apoptosis by inhibiting the expression of TNF receptor-associated factor 1

  5. Together, these data support the clinical evaluation of dual angiogenic inhibition of the ALK1 and VEGF pathways in patients with advanced renal cell carcinoma (RCC) .

  6. the patients with systemic sclerosis had significantly increased serum levels of SLPI in comparison with the rheumatoid arthritis patients and the healthy controls

  7. gene expression profiling study based on microarray data for the three cell types identified a number of candidates, including LCP1 and GLI, that could be key molecules in the mechanism of SLPI-induced cell migration

  8. we show that SLPI acts as a key mediator in regulating the function of hepatic myeloid cells, to promote resolution responses through induction of MerTK expression within the resident macrophage population.

  9. these data demonstrate increased anti-inflammatory activity of the SLPI-A16G protein compared with SLPI-WT in a murine model of pulmonary Pseudomonas infection

  10. we demonstrated that the oncogenic effect of SLPI may be due to protection of growth factor progranulin from enzymatic cleavage or suppression of castration-resistant prostate cancer (CRPC)cell apoptosis independent of anti-protease activity of SLPI. These findings implicate SLPI as a potential biomarker of resistance to AR inhibition and therapeutic target for CRPC treatment

  11. Secretory leukocyte protease inhibitor mediates invasiveness of oral carcinoma cells.

  12. The results indicate that SERPINE2 and SLPI play a significant role in the development of papillary thyroid cancer and imply that the evaluation of serum concentrations of both anticoagulant molecules may be considered as additional marker for the differentiation of malignancies during the preoperative diagnosis of patients with thyroid gland tumors.

  13. Bronchial epithelial cells have decreased SLPI expression in response to hypoxia.

  14. Ongoing herpes simplex virus infection and resultant downregulation of local levels of SLPI may impart a greater susceptibility for keratinocytes to human papillomavirus type 16 infection through the host cell receptor annexin A2.

  15. SLPI is an independent predictor for both OS and DSS and a relevant prognostic biomarker in OSCC.

  16. The elevations in cervical elafin and SLPI expression in the women with preterm delivery might reflect the local response to the pathogen invasion into the cervix preceding preterm labor.

  17. These results demonstrate that SLPI down-regulates pIgR expression through the NF-kappaB signaling pathway by inhibiting degradation of IkappaBbeta protein.

  18. Abnormal over-expression of SLPI in pancreatic cancer cells may be associated with the development of disease through its roles in promoting cancer cell survival and proliferation as well as anti-apoptosis.

  19. study identifies a distinct immune response in SA characterized by a dysregulated IFN-gamma/SLPI axis that affects lung function.

  20. findings support a controlling role for SLPI in NET generation, which is of potential relevance to infectious and autoinflammatory diseases

Mouse (Murine) Secretory Leukocyte Peptidase Inhibitor (SLPI) interaction partners

  1. We demonstrate by silencing the SLPI gene, that SLPI negatively regulates human periodontal ligament cell expression of the pro-inflammatory cytokines IL-6 and MCP-1.

  2. MIF-2/D-DT is an early response cytokine in the I/R injury repair of the proximal tubule, enhancing regeneration through SLPI- and ATF4-dependent mechanisms.

  3. Slpi(-/-) mice had impaired collagen gene expression but animals demonstrated minimal reduction in lung fibrosis compared with wild-type animals. These data suggest that enhanced proteolysis does not further enhance TGF-beta activation, and inhibits sustained Col1alpha1, Col3alpha1, and Col4alpha1 gene expression following lung injury.

  4. Data show that differentiative switches between bronchiolar progenitors and club cells are under the Nrf2-mediated control of SLPI and syndecan 4.

  5. study identifies a distinct immune response in SA characterized by a dysregulated IFN-gamma/SLPI axis that affects lung function.

  6. Studied the function of Secretory Leukocyte Protease Inhibitor (SLPI) in odontoblast during mouse tooth development.

  7. Data show that the expression of several genes encoding salivary antimicrobial proteins, such as secretory leukocyte peptidase inhibitor (SLPI), S100A8, and lactotransferrin, was reduced due to myeloid differentiation dactor 88 (MyD88) deficiency.

  8. a possible role for SLPI in enhancing the metastatic behavior of breast cancer cell line 4T1

  9. These studies define an important role for SLPI in innate and adaptive immunity and offer new insight into strategies for the use of this naturally occurring molecule in the modulation of infectious and inflammatory diseases.

  10. In experimental autoimmune encephalomyelitis, SLPI exerts potent pro-inflammatory actions by modulation of T-cell activity

  11. The results underscore the importance of SLPI as a modulator of specific immunity that can also function at peripheral sites under pathogenic pressure.

  12. SLPI has a role in wound healing and innate immunity

  13. Results suggest that secretory leukoprotease inhibitor (SLPI) attenuates excessive inflammatory responses and thus assures balanced functioning of innate immunity.

  14. a causal role for SLPI in the malignant behavior of cancer cells, underscoring the potential malignancy-promoting activities of SPIs

  15. Macrophages secrete an increased amount of SLPI when encountering apoptotic cells, which may help to attenuate potential inflammation during clearance of these cells.

  16. Gene augmentation of murine SLPI suggests a novel and extended anti-inflammatory role for this human neutrophil elastase inhibitor working as an effector of innate immunity to protect tissues against maladaptive inflammatory responses.

  17. SLPI is a pivotal endogenous factor necessary for optimal tissue repair including intra-oral wound healing

  18. SLPI localizes in part along the megakaaryocyte and platelet cytoskeleton by virtue of specific interactions with beta1 tubulin.

  19. Secretory leukocyte protease inhibitor has a role in cancer development

  20. Suppression of macrophage responses to bacterial lipopolysaccharide (LPS) by secretory leukocyte protease inhibitor (SLPI) is independent of its anti-protease function.

SLPI Protein Profile

Protein Summary

This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes\; the protein is also thought to have broad-spectrum anti-biotic activity.

Gene names and symbols associated with SLPI

  • secretory leukocyte peptidase inhibitor (SLPI)
  • secretory leukocyte peptidase inhibitor (Slpi)
  • ALK1 protein
  • ALP protein
  • BLPI protein
  • ckpi protein
  • HUSI protein
  • HUSI-I protein
  • MATN4 protein
  • MPI protein
  • SLPI protein
  • WAP4 protein
  • WFDC4 protein

Protein level used designations for SLPI

HUSI-1 , WAP four-disulfide core domain protein 4 , antileukoproteinase , mucus proteinase inhibitor , protease inhibitor WAP4 , secretory leukocyte protease inhibitor (antileukoproteinase) , seminal proteinase inhibitor , ALP , secretory leukocyte protease inhibitor , matrilin 4 , secretory leukocyte peptidase inhibitor

6590 Homo sapiens
20568 Mus musculus
84386 Rattus norvegicus
396886 Sus scrofa
504598 Bos taurus
641306 Ovis aries
711156 Macaca mulatta
740668 Pan troglodytes
100127207 Canis lupus familiaris
100137514 Papio anubis
100137521 Pongo abelii
100722975 Cavia porcellus
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