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SLPI encodes a secreted inhibitor which protects epithelial tissues from serine proteases. Additionally we are shipping SLPI Antibodies (115) and SLPI Kits (52) and many more products for this protein.
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we investigated the biological effects of SLPI using Cell Counting Kit (CCK)-8 (show CCK Proteins), Annexin V (show ANXA5 Proteins)/PI apoptosis assay and Caspase (show CASP3 Proteins)-Glo(R) 3/7 assay. The findings revealed that SLPI promoted apoptosis in the Leuk1 and WSU-HN4 cell lines. Mechanistic studies indicated that SLPI, at least in part, regulated cell apoptosis by inhibiting the expression of TNF receptor-associated factor 1 (show TRAF1 Proteins)
Together, these data support the clinical evaluation of dual angiogenic inhibition of the ALK1 (show ACVRL1 Proteins) and VEGF (show VEGFA Proteins) pathways in patients with advanced renal cell carcinoma (show MOK Proteins) (RCC (show XRCC1 Proteins)) .
the patients with systemic sclerosis had significantly increased serum levels of SLPI in comparison with the rheumatoid arthritis patients and the healthy controls
gene expression profiling study based on microarray data for the three cell types identified a number of candidates, including LCP1 (show LCP1 Proteins) and GLI (show GLI1 Proteins), that could be key molecules in the mechanism of SLPI-induced cell migration
we show that SLPI acts as a key mediator in regulating the function of hepatic myeloid cells, to promote resolution responses through induction of MerTK (show MERTK Proteins) expression within the resident macrophage population.
these data demonstrate increased anti-inflammatory activity of the SLPI-A16G protein compared with SLPI-WT in a murine model of pulmonary Pseudomonas infection
we demonstrated that the oncogenic effect of SLPI may be due to protection of growth factor progranulin (show GRN Proteins) from enzymatic cleavage or suppression of castration-resistant prostate cancer (CRPC)cell apoptosis independent of anti-protease activity of SLPI. These findings implicate SLPI as a potential biomarker of resistance to AR inhibition and therapeutic target for CRPC treatment
Secretory leukocyte protease inhibitor mediates invasiveness of oral carcinoma cells.
The results indicate that SERPINE2 (show SERPINE2 Proteins) and SLPI play a significant role in the development of papillary thyroid cancer and imply that the evaluation of serum concentrations of both anticoagulant molecules may be considered as additional marker for the differentiation of malignancies during the preoperative diagnosis of patients with thyroid gland tumors.
Bronchial epithelial cells have decreased SLPI expression in response to hypoxia.
We demonstrate by silencing the SLPI gene, that SLPI negatively regulates human periodontal ligament cell expression of the pro-inflammatory cytokines IL-6 (show IL6 Proteins) and MCP-1 (show CPT1B Proteins).
MIF-2 (show HSPA5 Proteins)/D-DT is an early response cytokine in the I/R injury repair of the proximal tubule, enhancing regeneration through SLPI- and ATF4 (show ATF4 Proteins)-dependent mechanisms.
Slpi(-/-) mice had impaired collagen gene expression but animals demonstrated minimal reduction in lung fibrosis compared with wild-type animals. These data suggest that enhanced proteolysis does not further enhance TGF-beta (show TGFB1 Proteins) activation, and inhibits sustained Col1alpha1, Col3alpha1, and Col4alpha1 gene expression following lung injury.
Data show that differentiative switches between bronchiolar progenitors and club cells are under the Nrf2 (show NFE2L2 Proteins)-mediated control of SLPI and syndecan 4 (show SDC4 Proteins).
study identifies a distinct immune response in SA characterized by a dysregulated IFN-gamma (show IFNG Proteins)/SLPI axis that affects lung function.
Studied the function of Secretory Leukocyte Protease Inhibitor (SLPI) in odontoblast during mouse tooth development.
Data show that the expression of several genes encoding salivary antimicrobial proteins, such as secretory leukocyte peptidase inhibitor (SLPI), S100A8 (show S100A8 Proteins), and lactotransferrin (show LTF Proteins), was reduced due to myeloid differentiation dactor 88 (MyD88 (show MYD88 Proteins)) deficiency.
a possible role for SLPI in enhancing the metastatic behavior of breast cancer cell line 4T1
These studies define an important role for SLPI in innate and adaptive immunity and offer new insight into strategies for the use of this naturally occurring molecule in the modulation of infectious and inflammatory diseases.
In experimental autoimmune encephalomyelitis, SLPI exerts potent pro-inflammatory actions by modulation of T-cell activity
This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes\; the protein is also thought to have broad-spectrum anti-biotic activity.
, WAP four-disulfide core domain protein 4
, mucus proteinase inhibitor
, protease inhibitor WAP4
, secretory leukocyte protease inhibitor (antileukoproteinase)
, seminal proteinase inhibitor
, secretory leukocyte protease inhibitor
, matrilin 4
, secretory leukocyte peptidase inhibitor