Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP) ELISA Kits

Human Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP) interaction partners

1. P-selectin may indicate thrombotic risk assessment in atrial fibrillation

2. results found that P-selectin-induced elevations of p-p38 and p-PI3K levels were significantly inhibited by hsa-miR-370, indicating that repressed sLe(x) level is able to reduce the P-selectin binding and therefore eliminating the P-selectin-induced activation of p38 and PI3K signaling.

3. In young adults from the general population, circulating P-selectin and E-selectin levels appear positively related to CMR-derived aortic wall thickness and PWV, possibly pointing towards atherogenic inflammatory arterial wall alterations.

4. polymorphisms of SELP have shown significant association with sP-selectin levels as well as vascular risk in T2DM patients

5. There is a direct correlation between p-selectin level and severe blood stasis in the left atrium.

6. Suggest role for soluble P-selectin in the diagnosis of venous thromboembolism.

7. Levels of E and P selectin showed positive correlation with the length of stay.

8. plasma level predictive of high residual platelet reactivity during maintenance-phase dual antiplatelet therapy

9. Kidney transplant has a significant restorative effect on platelet aggregation and coagulation functions independent of platelet activation, as evaluated with P-selectin levels.

10. In Chinese Han population cardiovascular disease (CVD) risk is significantly higher in carriers with rs1800805-A allele (GA and AA) in the selectin P gene (SELP) than those with GG genotype. CVD risk is the highest for rs1800805-GA or AA carriers with additional genetic polymorphisms 1800796-GC or CC in interleukin 6 gene.

11. VWF, GMP-140, ADAMTS13 and the cerebral vasospasm, delayed cerebral ischemia, tumor diameter and prognosis of aneurysmal subarachnoid hemorrhage patients are closely related

12. The highest level of sP-selectin in colorectal patients was observed in patients with metastases to the liver (stage IV), and was significantly higher than in patients without metastases (stage I/II) and with lymph node metastases (stage III), p = .02. P-selectin plays an important role in the progression of CRC

13. Serum P-selectin levels are not altered in cystic fibrosis patients.

14. miR-223, miR-26b, miR-126 and miR-140 are expressed at a lower level in platelets and megakaryocytes in type 2 diabetics causing up-regulation of P2RY12 and SELP mRNAs that may contribute to adverse platelet function.

15. coronary thrombi in STEMI patients resistant to fibrinolysis are characterised by higher fibrin, P-selectin and VWF content than lysis-sensitive thrombi

16. P-Selectin and ICAM-1 have roles in mediating THP-1 monocyte adhesion

17. Transgenic expression of SELP is atherogenic in Apoe(-/-) mice, suggesting that P-selectin contributes to atherogenesis.

18. These results provide a novel insight into the mechano-chemical regulation mechanism for P-selectin-induced calcium signaling of neutrophils in flow.

19. Data indicate no association of maternal or fetal ITGA2 C807T SNP, ITGB3 T1565C SNP, PECAM1 CTG - GTG and SELP A/C polymorphisms with fetal growth restriction (FGR).

20. Study concluded that the genotype and allele frequencies of SELP S290N were not significant different between the acute ischemic stroke case group and the control group as well as between each subtype group and the control group

Horse (Equine) Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP) interaction partners

1. Despite the decrease of CD62P expression, the observed increased surface expression of CD41/61 on platelets in horses with recurrent airway obstruction may contribute to the formation of platelet aggregates in their respiratory system.

Cow (Bovine) Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP) interaction partners

1. Five single nucleotide polymorphisms (SNPs) from different exons in selectin SELP, two in selectin SELL and one in selectin SELE were taken forward to genotyping in 337 Holstein Friesian heifers using PCR-RFLP.

2. SELP mediates the attachment of peripheral blood leukocytes to endothelium and provides novel evidence that its high polymorphism is likely to affect biological function. This may potentially influence leukocyte migration and fertility, both key to successful performance in dairy cows.

Mouse (Murine) Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP) interaction partners

1. Choroid plexus endothelial cells are conventionally polarized, but express P-cadherin at cell-cell contacts, and Lgl2 and syntaxin-4 in the luminal plasma membrane domain.

2. Platelet Ral GTPases primarily control P-selectin surface expression, in turn regulating platelet-leukocyte interaction.

3. In a laser injury-induced thrombosis model, P-selectin modulates thrombus propagation independently of VWF and TSP1

4. deletion of P-sel disrupted megakaryocyte/neutrophil interactions in spleen, reduced TGF-beta content, and corrected the hematopoietic stem cells distribution that in Gata1(low) mice, as in primary myelofibrosis patients, is abnormally expanded in spleen.

5. The present study supported the notion that CD62P accumulation during platelet storage is involved in mediating transfusion-related acute lung injury.

6. Holothurian glycosaminoglycan has emerged as a novel anti-cancer agent via blocking P-selectin-mediated malignant events of tumor metastasis.

7. Data (including data from studies in transgenic mice) suggest that sequence variations limited to 1.4-kb proximal promoter region account for most differences in expression of murine Selp and human SELP genes.

8. P-selectin has a role in endothelial progenitor cells' inhibition of platelet function

9. Both platelet and endothelial cell P-selectin contribute to host defense during Klebsiella pneumosepsis.

10. Platelet infiltration into solid tumors occurs through a P-selectin-dependent mechanism and promotes tumor growth.

11. P-selectin promotes neutrophil extracellular trap (NET) formation and is a potential target for NET-related diseases.

12. P-selectin is an important adhesion molecule vital for infiltration of regulatory T cells into mouse mammary tumors

13. Administering human recombinant PTX3 to wild-type mice induced endothelial dysfunction and increased blood pressure, an effect absent in P-selectin-deficient mice.

14. Targeting P-selectin-mediated platelet adhesion onto endometriotic lesions holds promise as a novel therapeutics for treating endometriosis.

15. Endothelial peroxisome proliferator-activated receptor-gamma protects against thrombosis through a mechanism that involves downregulation of P-selectin expression and diminished P-selectin-mediated leukocyte-endothelial interactions.

16. involved in neutrophil recruitment into the kidney after induction of sepsis

17. Regulatory T cells dynamically regulate P and E selectin ligand expression during multiple challenge contact hypersensitivity.

18. These results demonstrate that chronically raised sP-selectin favours progression of an unstable atherosclerotic plaque phenotype.

19. P-selectin-mediated platelet adhesion promotes the metastasis of murine melanoma cells.

20. In the absence of either PSGL-1 or E- and P-selectin.