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The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection (Leighton et al., 2001 [PubMed 11242070]).[supplied by OMIM, Feb 2011].. Additionally we are shipping SEMA6A Antibodies (90) and SEMA6A Kits (1) and many more products for this protein.
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Sema6a and Plxna2 (show Plxna2 Proteins) have roles in promoting eye vesicle cohesion through mediating spatially regulated repulsion within the developing zebrafish eye
describes the experiments and methods enabling the characterization of Semaphorin 6A as a critical regulator of endothelial cell survival and vessel function
miR (show MLXIP Proteins)-203 induces the apoptosis of YD-38 human oral cancer cells by directly targeting SEMA6A.
our findings indicated that SEMA6A may be a potential prognostic biomarker in the treatment of Glioblastoma multiforme
Data suggest that Sema6A and Mical1 (show MICAL1 Proteins) may represent new potential therapeutic targets in BRAFV600E melanoma.
We identified the SEMA6A and HLA-DP (show HLA-DPB1 Proteins) loci as significant contributors to risk for granulomatosis with polyangiitis.
Data show that miR (show MLXIP Proteins)-27a/b regulated the expression of the angiogenesis inhibitor semaphorin 6A (SEMA6A) in vitro and in vivo and targeted the 3'-untranslated region of SEMA6A.
Strong expression of SEMA6A is associated with langerhans cells of histiocytosis or dermatopathic lymphadenitis
NANOG (show NANOG Proteins)-, SOX2 (show SOX2 Proteins)-, and POU5F1 (OCT3/OCT4 (show POU5F1 Proteins))-binding sites within intron 1 of the SEMA6A gene
findings suggest for SEMA6A a novel function in the cytoskeleton and a role in modulating tubulin (show TUBB Proteins) isotype composition and microtubule dynamics
mutations in Sema6A, and/or possibly interacting genes, may result in dysfunction at the level of neuronal networks with associated behavioural phenotypes of relevance to neuropsychiatric disorders
The experiments reveal the complex nature of Sema6A biochemical functions and the molecular logic of the context-dependent interactions between Sema6A and PlxnA2 (show Plxna2 Proteins).
Using time-lapse videomicroscopy we provide evidence that Sema6A/PlexinA2 signaling participates to interkinetic nuclear migration of retinal progenitor cell
findings reveal a unique function of Nrf2 (show NFE2L2 Proteins) in reprogramming ischemic tissue toward neurovascular repair via Sema6A regulation, providing a potential therapeutic strategy for ischemic retinal and CNS diseases
Tangential migration is selectively altered in cerebellar neurons of Sema6A knockouts.
semaphorin 6A is expressed in On starburst amacrine cell.
Sema6A expressed in oligodendrocyte precursor cells is involved in their autonomous migration through ligand-receptor interaction with Plexin-A4 (show PLXNA4 Proteins) expressed in surrounding cells.
The results of this study suggested that Sema6A might have a role in myelination by controlling oligodendrocyte differentiation.
Adult Sema6A-null mice exhibit reduced tumor, matrigel, and choroidal angiogenesis compared with controls. Here we show that it also regulates vascular development and adult angiogenesis.
null mutations in Sema6A or PlexinA4 (PlexA4 (show PLXNA4 Proteins)) exhibit a pronounced defect in OPL (show ZIC1 Proteins) stratification of horizontal cell axons without any apparent deficits in bipolar cell dendrite or photoreceptor axon targeting.
The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection (Leighton et al., 2001
, semaphorin 6A1
, sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
, sema VIa
, semaphorin 6A-1
, semaphorin VIA
, Mutant line 997
, sema Q
, sema VIA
, semaphorin Q