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Data indicate that semenogelin I (Sg I) expression has potential value in predicting renal cell carcinoma (RCC) progression and prognosis, suggesting the use of Sg I as a biomarker for RCC.
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Peptides from the antimicrobial protein semenogelin I have antibacterial activity.
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EPPIN and SEMG1 rapidly co-evolved in primates
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SEMG1 was significantly changed in asthenozoosperm, which could be the candidate gene for the development of diagnostic marker and provided the opportunity to further illustrate the biological mechanisms of asthenozoospermia.
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Three regions of SEM1(86-107) comprise the amyloid fibril core that enhances HIV-1 infection.
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Interaction analysis identifies semenogelin I fragments as new binding partners of PIP in human seminal plasma
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EPPIN's semenogelin I binding site: a contraceptive drug target.
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Nuclear semenogelin I expression could be a reliable prognosticator in men who undergo radical prostatectomy.
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The proteomes of the type-1 diabetic, type-2 diabetic, and non-diabetic obese patients presented elevated amounts of the same set of one molecular form of semenogelin-1, one form of clusterin, and two forms of lactotransferrin.
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Peptides released by physiological cleavage of Semg1 and Semg2 form amyloids that enhance HIV infection.
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These results suggest the involvement of semenogelins in prostate cancer and their prognostic values in predicting cancer progression after radical prostatectomy.
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Spermatozoa interact with semenogelin I in solution in a non-Zn2+-dependent manner, but associate with immobilized semenogelin I only in the presence of Zn2+.
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Cysteine 239 of rSEMG1 appears to be the critical amino acid for both binding to eppin and inhibiting sperm motility.
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Transcripts in the gastro-intestinal tract and skeletal muscle almost exclusively encoded SgI
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Seminal plasma motility inhibitor, one of the fragments of Sg, has its inhibitory effect on ejaculated spermatozoa in liquefied semen under physiological conditions.
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peptides produced by cleavage of semenogelin I, the predominant human semen coagulum protein, had high levels of antibacterial activity.
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structural changes in the semenogelin 1 and 2 proteins that have arisen since the human-chimpanzee-gorilla split may be responsible for the physiological differences between these species ejaculated semen that correlate with their sociosexual behavior
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The binding of Zn2+ to SgI and SgII and their involvment in regulating the activity of PSA are reported.
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in seminal plasma and on spermatozoa following ejaculation, Eppin is bound to semenogelin I
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Authors analyzed an intronic T9 repeat of semenogelin I (SEMG1) and report mutation frequencies of 51% (75 of 146) and 62% (8 of 13) in MMR-deficient primary colorectal cancers and cell lines, respectively.
