Septin 12 Proteins (Sep12)

Sep12 encodes a guanine-nucleotide binding protein and member of the septin family of cytoskeletal GTPases. Additionally we are shipping Septin 12 Antibodies (36) and Septin 12 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Sep12 124404 Q8IYM1
Mouse Sep12 Sep12 71089  
Rat Sep12 Sep12 363542 Q4V8G5
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Top Septin 12 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$547.80
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,986.50
Details
Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
$582.75
Details

Sep12 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,

More Proteins for Septin 12 (Sep12) Interaction Partners

Human Septin 12 (Sep12) interaction partners

  1. In mature human spermatozoa, SEPT12 and NDC1 are majorly colocalized in the centrosome regions; however, NDC1 is only slightly co-expressed with SEPT12 at the annulus of the sperm tail.

  2. results demonstrate the molecular architecture of SEPT12 filaments at the sperm annulus, their mechanical support of sperm motility, and their correlation with male infertility.

  3. we discovered that the SEPTIN12-microtubule complexes are critical for sperm formation during spermiogenesis

  4. SEPTIN12 genetic variants confer susceptibility to teratozoospermia

  5. Eight coding single-nucleotide polymorphisms in SEPTIN12 were detected in the patients with Sertoli cell-only syndrome. Analysis of the results suggest that SEPTIN12 might play a critical role in human spermatogenesis.

  6. SEPT12 mutations cause male infertility with defective sperm annulus and disrupt sperm structural integrity

  7. The c.204G>C (Gln38His) variant in the SEPTIN12 gene was associated with increased susceptibility to azoospermia caused by meiotic arrest

  8. While SEPT12 formed filamentous structures at interphase, it was localized to the central spindle and to midbody during anaphase and cytokinesis, respectively.

  9. Decreases in SEPTIN12 expression is associated with male infertility.

Mouse (Murine) Septin 12 (Sep12) interaction partners

  1. Data suggest that SEPT12 phosphorylation inhibits septin (show SEPT6 Proteins) ring assembly during annulus biogenesis.

  2. In mice sperm with mutated SEPT12, NDC1 dispersed around the manchette region of the sperm head and annulus, compared with concentrating at the sperm neck of wild-type sperm.

  3. results demonstrate the molecular architecture of SEPT12 filaments at the sperm annulus, their mechanical support of sperm motility, and their correlation with male infertility.

  4. Oocytes fertilized with spermatozoa obtained from Septin 12+/- chimeric mice failed to develop beyond the morula stage after IVF (show SCN5A Proteins) and intracytoplasmic sperm injection because of significant DNA defects in the spermatozoa

Septin 12 (Sep12) Protein Profile

Protein Summary

This gene encodes a guanine-nucleotide binding protein and member of the septin family of cytoskeletal GTPases. Septins play important roles in cytokinesis, exocytosis, embryonic development, and membrane dynamics. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Septin 12 Proteins (Sep12)

  • septin 12 S homeolog (sept12.S)
  • septin 12 (SEPT12)
  • septin 12 (sept12)
  • septin 12 (Sept12)
  • 1700028G04Rik protein
  • 4933413B09Rik protein
  • fe23c11 protein
  • MGC68931 protein
  • Septin12 protein
  • si:dkey-23a11.2 protein
  • SPGF10 protein
  • wu:fe23c11 protein

Protein level used designations for Septin 12 Proteins (Sep12)

septin 12 , septin-12

GENE ID SPECIES
379651 Xenopus laevis
748303 Pan troglodytes
100339863 Oryctolagus cuniculus
564600 Danio rerio
124404 Homo sapiens
100688231 Canis lupus familiaris
618676 Bos taurus
71089 Mus musculus
363542 Rattus norvegicus
416408 Gallus gallus
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