Septin 4 Proteins (SEPT4)

Human Septin 4 (SEPT4) interaction partners

1. carnosic acid induces parkin by enhancing the ubiquitination of ARTS, leading to induction of XIAP.

2. In this review, we will discuss the recent advances of the tauopathy research, primarily focusing on its association with the early axonal manifestation of axonal transport defect, axonal mitochondrial stress, autophagic vesicle accumulation and the proceeding of axon destruction, and the pathogenic Tau spreading across the synapse.

3. Septin4 is a novel essential factor involved in oxidative stress induced vascular endothelial cell injury by interacting with apoptosis-related protein PARP1.

4. The data suggest that Sept4_i1 induces hepatic stellate cell apoptosis by inhibiting Akt and Bcl-2 expression and up-regulating PPAR-gamma expression.

5. results suggest that Septin4 may be involved in the process of activation of hepatic stellate cells by lipopolysaccharide stimulation.

6. Bradeion/SEPT4 transcript levels are significantly increased in patients with transitional cell bladder cancer.We hypothesize that Bradeion is directly involved in bladder cancer pathogenesis with the highest expression at early cancer stages.

7. Identification of a novel anti-apoptotic E3 ubiquitin ligase that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC, HtrA2, and ARTS.

8. these data suggests a tumor suppressor role of SEPT4_i1 in HCC through regulating hepatocellular carcinoma cell apoptosis.

9. SEPT4 is a Notch target gene.

10. The expression of SEPT4 is significantly decreased in the ejaculated sperm of idiopathic asthenozoospermia patients.

11. ARTS is localized at mitochondria and promotes programmed cell death (apoptosis).

12. role of Bradeion in colorectal neoplasms

13. Sept4 is involved in the formation of cytoplasmic inclusions as well as induction of cell death in alpha-synuclein-associated neurodegenerative disorders.

14. Data suggest that ARTS induces apoptosis by antagonizing IAPs, including XIAP.

15. SEPT8 and SEPT4 are localized surrounding alpha-granules. Activation of platelets by agonists resulted in the translocation of SEPT4 and SEPT8 to the platelet surface indicating a possible functional role of these proteins in platelet granular secretion

16. ARTS can function as a tumor suppressor protein in childhood acute lymphocytic leukemia.

17. We studied the assembly of three human septins, SEPT4, SEPT5 and SEPT8, with each other (heterotypic) and with themselves (homotypic) using a yeast two-hybrid system.

18. high cellular levels of ARTS protein sensitize cells toward apoptosis

19. The data presented here suggest that ARTS P-loop is not frequently mutated in gastric, lung, and hepatocellular carcinomas, and that apoptosis deregulation in cancers is not dependent on the mutation of ARTS gene.

20. Finds somatic mutation in P-loop domains of proapoptotic ARTS genes uncommon in colon cancers.

Mouse (Murine) Septin 4 (SEPT4) interaction partners

1. the pro-apoptotic protein ARTS (a Septin4 isoform) is highly expressed in cells comprising the intestinal stem cell niche and that its deletion protects Lgr5(+) and Paneth cells from undergoing apoptotic cell death.

2. Adenovirus-Sept4 can attenuate the development of liver fibrosis induced by S. japonicum through apoptosis.

3. The inhibition of the expression of the SEPT4 by praziquantel might be due to alleviation of the inflammatory response at the chronic and advanced stage of S. japonicum infection.

4. The hypothetical pathogenicity by the chronic overload of SEPT4 alone, if any, is insufficient to trigger neurodegenerative process in the mouse brain.

5. Sept4/ARTS(-/-) mice display marked improvement in wound healing and regeneration of hair follicles.

6. Identification of a novel anti-apoptotic E3 ubiquitin ligase that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC, HtrA2, and ARTS.

7. Report SEPT4/5/7 expression in mouse cochlea and roles in auditory function.

8. Sept4 and alpha-SMA may interact together in hepatic stellate cells (HSCs). Sept4 seems to be involved in the formation of inflammatory granulomata and subsequent liver fibrosis by regulating HSCs activation.

9. ARTS (Septin 4) promotes apoptosis mainly through binding and antagonizing XIAP.

10. Loss of Sept4 is associated with myofibroblastic transformation of hepatic stellate cells and results in liver fibrosis.

11. Findings suggest that Sept4-null mice develop malignancies due to increased resistance of their HSPCs to apoptosis.

12. These results suggest that Sept14 is involved in neuronal migration in cerebral cortex via interaction with Sept4.

13. On Sept4(-/-) sperm, domain confinement was lost, and basigin localized over the entire plasma membrane.

14. M-Septin is a novel mitochondrial septin that interacts with CRMP/CRAM in developing neurons.

15. Cortical organization based on circular assembly of the septin cytoskeleton is essential for the structural and mechanical integrity of mammalian spermatozoa.

16. Sept4 proteins play distinct but evolutionarily conserved functions in different cellular compartments.

17. hepatic stellate cell-specific septin subunit Sept4 and perhaps the septin system are involved in the suppressive modulation of myofibroblastic transformation and fibrogenesis associated with liver diseases

18. The interaction of DNAJB13 with SEPT4 in vitro and its spatiotemporal association with the annulus during sperm flagellum development suggest that DNAJB13 may be involved in assembling the annulus structure.