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SEPT4 is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Additionally we are shipping Septin 4 Antibodies (76) and many more products for this protein.
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Septin4 is a novel essential factor involved in oxidative stress induced (show SQSTM1 Proteins) vascular endothelial cell injury by interacting with apoptosis-related protein PARP1 (show PARP1 Proteins).
The data suggest that Sept4_i1 induces hepatic stellate cell apoptosis by inhibiting Akt (show AKT1 Proteins) and Bcl-2 (show BCL2 Proteins) expression and up-regulating PPAR-gamma (show PPARG Proteins) expression.
Bradeion/SEPT4 transcript levels are significantly increased in patients with transitional cell bladder cancer.We hypothesize that Bradeion is directly involved in bladder cancer pathogenesis with the highest expression at early cancer stages.
Identification of a novel anti-apoptotic E3 ubiquitin ligase (show MUL1 Proteins) that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC (show DIABLO Proteins), HtrA2 (show HTRA2 Proteins), and ARTS.
these data suggests a tumor suppressor role of SEPT4_i1 in HCC (show FAM126A Proteins) through regulating hepatocellular carcinoma cell apoptosis.
SEPT4 is a Notch (show NOTCH1 Proteins) target gene.
The expression of SEPT4 is significantly decreased in the ejaculated sperm of idiopathic asthenozoospermia patients.
role of Bradeion in colorectal neoplasms
Sept4 is involved in the formation of cytoplasmic inclusions as well as induction of cell death in alpha-synuclein-associated neurodegenerative disorders.
Data suggest that ARTS induces apoptosis by antagonizing IAPs, including XIAP (show XIAP Proteins).
Adenovirus-Sept4 can attenuate the development of liver fibrosis induced by S. japonicum through apoptosis.
The inhibition of the expression of the SEPT4 by praziquantel might be due to alleviation of the inflammatory response at the chronic and advanced stage of S. japonicum infection.
The hypothetical pathogenicity by the chronic overload of SEPT4 alone, if any, is insufficient to trigger neurodegenerative process in the mouse brain.
Sept4/ARTS(-/-) mice display marked improvement in wound healing and regeneration of hair follicles.
Report SEPT4/5/7 expression in mouse cochlea and roles in auditory function.
Sept4 and alpha-SMA (show SMN1 Proteins) may interact together in hepatic stellate cells (HSCs). Sept4 seems to be involved in the formation of inflammatory granulomata and subsequent liver fibrosis by regulating HSCs activation.
ARTS (Septin 4) promotes apoptosis mainly through binding and antagonizing XIAP (show XIAP Proteins).
Loss of Sept4 is associated with myofibroblastic transformation of hepatic stellate cells and results in liver fibrosis.
Findings suggest that Sept4-null mice develop malignancies due to increased resistance of their HSPCs to apoptosis.
This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct\; it is localized to the mitochondria, and has a role in apoptosis and cancer.
expression gene 3 in rat visual cortex
, expression gene 3-1 in rat visual cortex
, peanut-like 2
, septin 4
, CE5B3 beta
, apoptosis-related protein in the TGF-beta signaling pathway
, bradeion beta
, brain protein H5
, cell division control-related protein 2
, cerebral protein 7
, peanut-like protein 2
, cell division control-related protein 2b
, peanut-like 2 homolog
, septin H5