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SEPT9 is a member of the septin family involved in cytokinesis and cell cycle control. Additionally we are shipping Septin 9 Antibodies (34) and Septin 9 Kits (1) and many more products for this protein.
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Studies indicate that methylated Septin 9 ((m)SEPT9) can be consistently detected in plasma samples derived from whole blood samples collected with S-Monovette(R) K3E and BD Vacutainer (R) K2EDTA tubes stored at 2-8 degrees C for a maximum of 24 h and for samples collected in S-Monovette CPDA tubes stored at 18-25 degrees C for up to 48 h.
our study has validated a new SEPT9 assay and combined testing as an aid in cancer detection, providing a new approach for opportunistic CRC (show CALR Proteins) screening.
Study shows a stepwise increase of SEPT9 methylation from non-cancerous to cancerous tissue in colorectal adenocarcinoma.
Study found SHOX2 (show SHOX2 Proteins) and SEPT9 frequently methylated in biliary tract cancers.
The first evidence of an interaction between septins and a nonmitotic kinesin is provided and it is suggested that SEPT9 modulates the interactions of KIF17 (show KIF17 Proteins) with membrane cargo.
SEPT9 promoter methylation and MN frequency, both measured in peripheral blood, occur at an early stage compared to carcinoma development, indicating that the approach might be suitable to monitor CRC (show CALR Proteins) development.
KRAS mutations and SEPT9 promoter methylation were present in 34% (29/85) and in 82% (70/85) of primary tumor tissue samples.
we demonstrate that SEPT9 negatively regulates EGFR (show EGFR Proteins) degradation by preventing the association of the ubiquitin ligase Cbl (show CBL Proteins) with CIN85 (show SH3KBP1 Proteins), resulting in reduced EGFR (show EGFR Proteins) ubiquitylation
provide a full overview of the theoretical basis, development, validation, and clinical applications of the SEPT9 assay for both basic science researchers and clinical practitioners
Results show that in plasma samples, elevated methylated SEPT9 (mSEPT9) values were detected in colorectal cancer, but not in adenomas. Tissue levels of mSEPT9 alone are not sufficient to predict mSEPT9 levels in plasma.
observations suggested that Sept9 contributed to alleviate liver fibrosis might partially through promoting activated HSCs apoptosis and this anti-fibrogenesis effect might be blocked by DNMT (show DNMT1 Proteins)-3a mediated methylation of Sept9
The altered T-cell homeostasis caused by the loss of Sept9 results in an increase of CD8 (show CD8A Proteins)(+) central memory T-cells.
SEPT9 gene amplification and overexpression during mouse breast tumorigenesis
Data reveal the importance of Sept9 for septin (show SEPT6 Proteins) filament formation and general cell stability.
Zebrafish possess two genes, sept9a and sept9b that, like humans, express multiple transcripts.
This gene is a member of the septin family involved in cytokinesis and cell cycle control. This gene is a candidate for the ovarian tumor suppressor gene. Mutations in this gene cause hereditary neuralgic amyotrophy, also known as neuritis with brachial predilection. A chromosomal translocation involving this gene on chromosome 17 and the MLL gene on chromosome 11 results in acute myelomonocytic leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been described.
, MLL septin-like fusion protein MSF-A
, Ov/Br septin
, ovarian/breast septin
, septin D1
, MLL septin-like fusion
, SL3-3 integration site 1 protein
, eighth septin
, septin-like protein