anti-Serine Racemase (SRR) Antibodies

catalyzes the conversion of L-serine to D-serine. Additionally we are shipping Serine Racemase Proteins (10) and Serine Racemase Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SRR 63826 Q9GZT4
SRR 27364 Q9QZX7
SRR 303306 Q76EQ0
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Top anti-Serine Racemase Antibodies at

Showing 10 out of 64 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-SRR Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: HCT15 cell lysate 100 μL Log in to see 2 to 3 Days
Human Mouse Un-conjugated FACS, IF, IHC, IHC (p), WB 100 μL Log in to see 11 to 14 Days
Human Mouse Un-conjugated FACS, IHC, IHC (p), WB 100 μL Log in to see 11 to 14 Days
Human Mouse Un-conjugated FACS, IF, WB 100 μL Log in to see 11 to 14 Days
Human Rabbit Un-conjugated IHC, IHC (p), WB Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Log in to see 11 to 14 Days
Human Rabbit Un-conjugated ELISA, WB Western blot analysis SRR using HepG2 whole cell lysates 100 μL Log in to see 11 to 12 Days
Human Mouse Un-conjugated FACS, IF, IHC (p), WB Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human brain tissue (A) and human heart tissue (B) using SRR monoclonal antibody, clone 9E8  under 10 ug/mL working concentration. Immunofluorescent staining of HepG2 cells (A) and COS7 cells (B) using SRR monoclonal antibody, clone 9E8  at 1:100 dilution. 50 μL Log in to see 11 to 12 Days
Human Rabbit Un-conjugated IF (p), IHC (p) Formalin-fixed and paraffin embedded rat brain labeled with Anti-Serine Racemase Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded rat kidney labeled with Anti-Serine Racemase Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining. 100 μL Log in to see 3 to 7 Days
Rat Rabbit Un-conjugated WB Western blot analysis of extracts of rat brain cells, using SRR antibody. 100 μL Log in to see 11 to 13 Days
Human Rabbit Un-conjugated ELISA, IHC   100 μL Log in to see Available

More Antibodies against Serine Racemase Interaction Partners

Human Serine Racemase (SRR) interaction partners

  1. SRR single nucleotide polymorphism, rs4523957, is associated with posttraumatic stress disorder.

  2. SRR was identified as a type 2 diabetes susceptibility gene. SRR plays a role in insulin secretion in vitro.

  3. rs391300 SNP, located on the serine racemase (SRR) gene and linked to increased susceptibility to type 2 diabetes, was associated with progression from mild cognitive impairment to probable Alzheimer's disease.

  4. Study found an inverse association between the genetic risk off schizophrenia based on 108 genome-wide significantly associated SNPs and the prevalence for treated migraine in a general population sample. This association was primary linked to SNPs associated with genes encoding proteins involved in glutamatergic neurotransmission and could be attributed to the single intronic variant rs4523957 in SRR.

  5. Data suggest that Ser-84 and Arg-135 are important in catalysis and substrate specificity of SRR.

  6. Magnesium and calcium ions differentially affect human serine racemase activity and modulate its quaternary equilibrium toward a tetrameric form

  7. MiR-193a-3p and miR-193a-5p play important roles in osteosarcoma metastasis through down-regulation of the Rab27B and SRR genes and therefore may serve as useful biomarkers for the diagnosis of osteosarcoma

  8. Loss-of-function mutation of the gene encoding serine racemase significantly attenuates excitotoxicity in retina.

  9. Serine racemase activity and dynamics are regulated by halides, ATP and malonate.

  10. In serine racemase, similarly to the related enzyme alanine racemase, the unprotonated pyridoxal-5'-phosphate -substrate intermediate is stabilized mostly due to solvation effects contributed by water molecules and active-site residues.

  11. FBXO22 protein is required for optimal synthesis of NMDA receptor coagonist D-serine by interacting with serine racemase, activating it, and preventing its targeting to membranes.

  12. cross-talk between allosteric and active sites, leading to the stabilization of two alternative protein conformations with ATP affinities of ~ 10 muM and 1.8 mm

  13. S84A serine racemase mutant behaved like serine dehydratase, whereas A65S serine dehydratase mutant acquired an additional function of using D-serine as a substrate.

  14. Six SNP(rs7754840 in CDKAL1, rs391300 in SRR, rs2383208 in CDKN2A/2B, rs4402960 in IGF2BP2, rs10830963 in MTNR1B, rs4607517 in GCK)risk alleles of type 2 diabetes were associated with GDM in pregnant Chinese women.

  15. The structural characteristics of SR obtained from live cells suggest that SR is sensitive to oxidation in vivo, perhaps consistent with a scenario in which such modification plays a role in feedback or other forms of regulation.

  16. Serine racemase and D-serine are involved in both pre-symptomatic and progressive phases of amyotrophic lateral sclerosis, demonstrating a link between mutant superoxide dismutase (SOD)1 and a glial-derived toxic mediator in transgenic mice.

  17. The SRR mRNA is elevated in people death with suicide.

  18. The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding

  19. Data report on the isolation of a cDNA encoding a human serine racemase (SRR) from a human neuronal like cell line.

  20. D-serine is synthesized in human placenta by the racemization of L-serine by serine racemase.

Mouse (Murine) Serine Racemase (SRR) interaction partners

  1. Serine racemase (SR) deficiency significantly prevented retinal ganglion cell (RGC) loss in diabetic mice. We conclude that D-serine is a critical factor in the degeneration of RGC in diabetic retinopathy (DR). Targeting SR expression or activity may be a strategy for ameliorating RGC loss in DR.

  2. Study to demonstrate that serine racemase inhibitor alleviates neuronal ischemic injury. Serine racemase inhibition acts on the neurovascular unit as a neuroprotectant and ameliorant of reductions in regional cerebral blood flow.

  3. These findings reveal the NMDAR-independent roles of SR in metabolism and cell survival.

  4. These data reveal the first evidence that Srr may regulate glucose homeostasis in peripheral tissues and provide circumstantial evidence that D-serine may be an endogenous islet NMDAR co-agonist in beta-cells.

  5. This study demonstrated that SR deficiency reduces retinal pigment epithelial cells response to laser-induced inflammatory stimuli, resulting in decreased production of a cascade of pro-angiogenic cytokines, including(.) NO and VEGF, and reduced macrophage recruitment, which contribute synergistically to attenuated angiogenesis.

  6. results indicate that SRR indeed acts as a d-Asp biosynthetic enzyme in some organs and/or tissues, and also provide evidences that there should be some additional enzyme for d-Asp synthesis in mammals.

  7. data show neuronal serine racemase could regulate the extracellular D-serine signaling responsible for N-methyl-D-aspartate type glutamate receptor activation in the hippocampus

  8. The retinal levels of d-serine are tightly controlled during the first week of postnatal life and vary according to deficiencies in Serine racemase.

  9. In the neocortex and hippocampus only 24-40% of interneurons expressed serine racemase.

  10. SR interacts with the synaptic proteins, postsynaptic density protein 95 (PSD-95) and stargazin, forming a ternary complex.

  11. The findings of this study suggest that D-serine-dependent NMDAR activity is involved in mediating the cellular and behavioral effects of 5-HT2AR activation.

  12. serine racemase in the skin epidermis is involved in the differentiation of epidermal keratinocytes and the formation of the skin barrier

  13. Disruption of D-serine synthesis, by blocking SRR, during developmental stages leads to behavioral abnormalities relevant to prodromal symptoms and schizophrenia.

  14. SRR and/or d-serine may be involved in the production of d-aspartic acid in mouse forebrains

  15. The serine racemase-null mutant mouse has less than 10% of normal brain D-serine in a model of schizophrenia

  16. The present findings suggest that serine racemase may be a target for the development of new therapeutic strategies for epileptic seizures.

  17. Serine racemase is expressed by the main neuronal populations in most brain regions, irrespective of the excitatory or inhibitory nature of the cells. (Review)

  18. Serine racemase is the major enzyme responsible for D-serine production in the mouse forebrain. Other pathways of D-serine production may exist in the brain and peripheral organs.

  19. In forebrain, serine racemase is predominantly expressed in glutamatergic neurons, and co-release of glutamate and D-serine is required for optimal activation of post-synaptic NMDA receptors.

  20. SRR-/- mice exhibited a significantly disrupted representation of the order of events in distinct experiences as showed by object recognition and odor sequence tests

Serine Racemase (SRR) Antigen Profile

Protein Summary

catalyzes the conversion of L-serine to D-serine

Gene names and symbols associated with anti-Serine Racemase (SRR) Antibodies

  • serine racemase (SRR) antibody
  • serine racemase (srr) antibody
  • serine racemase (NGR_b19540) antibody
  • serine racemase (ZPR_3642) antibody
  • serine racemase (MGYG_07950) antibody
  • Serine racemase (Halhy_2637) antibody
  • Serine racemase (Runsl_3290) antibody
  • serine racemase (Srr) antibody
  • DDBDRAFT_0188432 antibody
  • DDBDRAFT_0230209 antibody
  • DDB_0188432 antibody
  • DDB_0230209 antibody
  • ILV1 antibody
  • ISO1 antibody
  • Srs antibody

Protein level used designations for anti-Serine Racemase (SRR) Antibodies

serine racemase , Serine racemase , D-serine ammonia-lyase , D-serine dehydratase , L-serine ammonia-lyase , L-serine dehydratase

100355322 Oryctolagus cuniculus
703426 Macaca mulatta
747543 Pan troglodytes
771635 Gallus gallus
4196066 Roseobacter denitrificans OCh 114
7789276 Sinorhizobium fredii NGR234
8627151 Dictyostelium discoideum AX4
9079513 Zunongwangia profunda SM-A87
10025016 Arthroderma gypseum CBS 118893
10586809 Haliscomenobacter hydrossis DSM 1100
10871823 Runella slithyformis DSM 19594
100144980 Xenopus (Silurana) tropicalis
100393154 Callithrix jacchus
100587573 Nomascus leucogenys
63826 Homo sapiens
27364 Mus musculus
303306 Rattus norvegicus
525340 Bos taurus
491200 Canis lupus familiaris
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