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catalyzes the conversion of L-serine to D-serine.
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Study found an inverse association between the genetic risk off schizophrenia based on 108 genome-wide significantly associated SNPs and the prevalence for treated migraine in a general population sample. This association was primary linked to SNPs associated with genes encoding proteins involved in glutamatergic neurotransmission and could be attributed to the single intronic variant rs4523957 in SRR.
Data suggest that Ser (show SIGLEC1 Antibodies)-84 and Arg-135 are important in catalysis and substrate specificity of SRR.
Magnesium and calcium ions differentially affect human serine racemase activity and modulate its quaternary equilibrium toward a tetrameric form
MiR (show MLXIP Antibodies)-193a-3p and miR (show MLXIP Antibodies)-193a-5p play important roles in osteosarcoma metastasis through down-regulation of the Rab27B (show RAB27B Antibodies) and SRR genes and therefore may serve as useful biomarkers for the diagnosis of osteosarcoma
Loss-of-function mutation of the gene encoding serine racemase significantly attenuates excitotoxicity in retina.
Serine racemase activity and dynamics are regulated by halides, ATP and malonate.
In serine racemase, similarly to the related enzyme alanine racemase, the unprotonated pyridoxal-5'-phosphate -substrate intermediate is stabilized mostly due to solvation effects contributed by water molecules and active-site residues.
FBXO22 (show FBXO22 Antibodies) protein is required for optimal synthesis of NMDA receptor coagonist D-serine by interacting with serine racemase, activating it, and preventing its targeting to membranes.
S84A serine racemase mutant behaved like serine dehydratase (show SDS Antibodies), whereas A65S serine dehydratase (show SDS Antibodies) mutant acquired an additional function of using D-serine as a substrate.
Six SNP(rs7754840 in CDKAL1 (show CDKAL1 Antibodies), rs391300 in SRR, rs2383208 in CDKN2A/2B, rs4402960 in IGF2BP2 (show IGF2BP2 Antibodies), rs10830963 in MTNR1B (show MTNR1B Antibodies), rs4607517 in GCK (show GCK Antibodies))risk alleles of type 2 diabetes were associated with GDM in pregnant Chinese women.
Study to demonstrate that serine racemase inhibitor alleviates neuronal ischemic injury. Serine racemase inhibition acts on the neurovascular unit as a neuroprotectant and ameliorant of reductions in regional cerebral blood flow.
These findings reveal the NMDAR (show GRIN1 Antibodies)-independent roles of SR in metabolism and cell survival.
These data reveal the first evidence that Srr may regulate glucose homeostasis in peripheral tissues and provide circumstantial evidence that D-serine may be an endogenous islet NMDAR (show GRIN1 Antibodies) co-agonist in beta-cells.
This study demonstrated that SR deficiency reduces retinal pigment epithelial cells response to laser-induced inflammatory stimuli, resulting in decreased production of a cascade of pro-angiogenic cytokines, including(.) NO and VEGF (show VEGFA Antibodies), and reduced macrophage recruitment, which contribute synergistically to attenuated angiogenesis.
results indicate that SRR indeed acts as a d-Asp (show C3 Antibodies) biosynthetic enzyme in some organs and/or tissues, and also provide evidences that there should be some additional enzyme for d-Asp (show C3 Antibodies) synthesis in mammals.
data show neuronal serine racemase could regulate the extracellular D-serine signaling responsible for N-methyl-D-aspartate type glutamate (show GRIN1 Antibodies) receptor activation in the hippocampus
The retinal levels of d-serine are tightly controlled during the first week of postnatal life and vary according to deficiencies in Serine racemase.
In the neocortex and hippocampus only 24-40% of interneurons expressed serine racemase.
SR interacts with the synaptic proteins, postsynaptic density protein 95 (PSD-95 (show DLG4 Antibodies)) and stargazin (show CACNG2 Antibodies), forming a ternary complex.
The findings of this study suggest that D-serine-dependent NMDAR (show GRIN1 Antibodies) activity is involved in mediating the cellular and behavioral effects of 5-HT2AR activation.
catalyzes the conversion of L-serine to D-serine
, Serine racemase
, D-serine ammonia-lyase
, D-serine dehydratase
, L-serine ammonia-lyase
, L-serine dehydratase