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SCML2 encodes a member of the Polycomb group proteins.
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SCML2A, an SCML2 isoform tightly associated to chromatin, contributes to PRC1 (show PRC1 Proteins) localization and also directly enforces repression of certain Polycomb (show CBX2 Proteins) target genes.
SCML2 directly interacts with USP7 (show USP7 Proteins) and drives its localization. SCML2 connects USP7 (show USP7 Proteins) to PRC1.4, allowing for the stabilization of BMI1 (show BMI1 Proteins), and USP7 (show USP7 Proteins) is found on SCML2 and BMI1 (show BMI1 Proteins) target genes.
Because PRC1 (show PRC1 Proteins) complexes localize to the promoters of a specific subset of developmental genes in vivo, the SLED domain of Scml2 may provide an important link connecting the PRC1 (show PRC1 Proteins) complexes to their target genes.
1.78-A crystal structure of the two MBT (show PRTN3 Proteins) repeats of SCML2 show significant structural similarities to the Tudor, PWWP, and chromo domains, suggesting probable evolutionary relationships and functional similarities between the MBT (show PRTN3 Proteins) repeats and these domains.
The malignant brain tumor repeats of SCML2 preferentially bind histone peptides monomethylated at lysine residues. The crystal structure of the complex reveals that the modified amino acid binds to an aromatic rich pocket.
This gene encodes a member of the Polycomb group proteins. These proteins form the Polycomb repressive complexes which are involved in transcriptional repression. The encoded protein binds histone peptides that are monomethylated at lysine residues and may be involved in regulating homeotic gene expression during development.
sex comb on midleg-like protein 2