anti-Sex Determining Region Y (SRY) Antibodies

This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. Additionally we are shipping Sex Determining Region Y Proteins (44) and Sex Determining Region Y Kits (20) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SRY 6736 Q05066
SRY 25221  
SRY 21674 Q05738
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Top anti-Sex Determining Region Y Antibodies at antibodies-online.com

Showing 10 out of 82 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-SRY Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  HepG2 cell lysate Host:  Rabbit  Target Name:  SRY  Sample Type:  HepG2  Antibody Dilution:  1.0ug/ml 100 μL Log in to see 2 to 3 Days
$319.00
Details
Human Mouse Un-conjugated FACS, IHC, ELISA, WB 100 μg Log in to see 11 to 16 Days
$426.40
Details
Human Rabbit Un-conjugated WB Western blot analysis of SRY using anti-SRY antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.   Lane 1: human Hela whole cell lysate.  After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-SRY antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for SRY at approximately 26KD. The expected band size for SRY is at 24KD. 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of SRY staining in human testis formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of SRY expression in HeLa (A) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HeLa cells, using SRY Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, IHC (p), WB Western Blot (WB) analysis of HeLa cells using SRY Polyclonal Antibody. 100 μL Log in to see Available
$181.73
Details
Human Mouse Un-conjugated WB 100 μL Log in to see 11 to 14 Days
$522.50
Details
Human Mouse Un-conjugated CyTOF, ELISA, FACS, IHC, WB Immunohistochemistry: SRY Antibody (1G4) [NBP2-37463] - Immunohistochemical analysis of paraffin-embedded ovarian cancer tissues using SRY mouse mAb with DAB staining. Western Blot: SRY Antibody (1G4) [NBP2-37463] - Western blot analysis using SRY mAb against human SRY recombinant protein. (Expected MW is 49.4 kDa) 0.1 mL Log in to see 7 to 9 Days
$516.98
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Mouse Un-conjugated IF, WB 100 μL Log in to see 11 to 14 Days
$507.83
Details

Top referenced anti-Sex Determining Region Y Antibodies

  1. Human Monoclonal SRY Primary Antibody for FACS, IHC - ABIN1098106 : Peng, Ivanov, Oh, Lau, Rauscher: Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery. in The Journal of biological chemistry 2009 (PubMed)
    Show all 2 Pubmed References

More Antibodies against Sex Determining Region Y Interaction Partners

Human Sex Determining Region Y (SRY) interaction partners

  1. results show that the transcriptional factor SRY specifically binds to different sites in the promoter sequence and has the ability to control CATSPER1 gene transcription.

  2. Activation of SRY and its downstream Sox9 and PDGFRalpha pathways are commonly involved in male hepatocarcinogenesis, which provides novel insights into gender disparity and sex-specific therapeutic strategies of hepatocellular carcinoma.

  3. a single-nucleotide polymorphism in the amelogenin gene using amplified product-length polymorphisms in combination with sex-determining region Y analysis, is reported.

  4. Missense Mutation 224G>T (R75M) in SRY Coding Region is associated with 46, XY Gonadal Dysgenesis.

  5. Chemical proteasome inhibition restored native-like SRY expression and transcriptional activity in association with restored occupancy of a sex-specific enhancer element in principal downstream gene Sox9, demonstrating that the variant SRY exhibits essentially native activity on a per molecule basis.

  6. SRY is involved in the maintenance of cancer stem-like characteristics through OCT4.

  7. The aim of this study was to compare two Y chromosome markers-SRY and DYS14-for their utility in the diagnosis of fetal gender

  8. These findings demonstrate that autosomal retention of SRY can be sub-microscopic and emphasize the importance of PCR and FISH in the genetic workup of the monosomic X male

  9. The SRY gene in plasma extracellular vesicles transferred to vascular endothelial cells may play an important role in the pathogenesis of atherosclerosis

  10. Results show that SRY could be expressed in tissues of Hirschsprung patients. It binds to the promoter of RET gene by competing with SOX10 for its interaction with PAX3 and NKX2-1 repressing their transcriptional expression and RET's as well.

  11. High levels of SRY expression correlated with cancer progression and poor HCC patient survival. However, high SRY levels are not significantly correlated with HCC sex bias.

  12. Findings demonstrate that the folding, trafficking, and gene-regulatory function of testis-determining factor SRY requires an invariant aromatic "buttress" beneath its specific DNA-bending surface.

  13. Overall, these results indicated that the main mechanism of sex reversal are not associated with mutations in the coding regions of SOX9 and DAX1 or copy number variations of SOX9, which is consistent with results of previous studies.

  14. Data suggest that sex-determining region Y protein SRY upregulation after dopamine cell injury is initially a protective response in males, but diminishes with gradual loss in dopamine cells.

  15. A proximal promoter construct for the MAS gene was repressed by the SOX [SRY (sex-determining region on the Y chromosome) box] proteins SRY, SOX2, SOX3 and SOX14, of which SRY is known to interact with the KRAB domain.

  16. Nucleocytoplasmic shuttling of SRY is necessary for robust initiation of testicular development.

  17. SRY may act as a transcription repressor for pluripotency-associated genes and as a transcription activator for differentiation-related genes in embryonic cells.

  18. SRY plays a role as a positive regulator of catecholamine synthesis and metabolism in the human male

  19. A novel SRY mutation leads to asymmetric SOX9 activation and is responsible for mixed 46,XY gonadal dysgenesis.

  20. 70-kDa heat shock cognate protein hsc70 mediates calmodulin-dependent nuclear import of the sex-determining factor SRY.

Cow (Bovine) Sex Determining Region Y (SRY) interaction partners

  1. analysis of mtDNA control region sequences and SRY gene sequences indicated more contribution to the Yunnan cattle from B. indicus than from B. taurus

  2. Mapped to the bovine Y chromosome (BTAY) by fluorescence in situ hybridization (FISH) and/or radiation hybrid (RH) mapping.

  3. New insights into SRY regulation through identification of 5' conserved sequence are reported.

Pig (Porcine) Sex Determining Region Y (SRY) interaction partners

  1. The 4.6 Kb of pig SRY 5' flanking sequences supported reporter transgene expression within the male genital ridge but not within the neural crest.

  2. New insights into SRY regulation through identification of 5' conserved sequence are reported.

Horse (Equine) Sex Determining Region Y (SRY) interaction partners

  1. This case represents the first report of an SRY negative XX-male sex reversal intersex phenotype, which is a potentially inherited condition, in an American saddlebred horse.

Rabbit Sex Determining Region Y (SRY) interaction partners

  1. CRISPR/Cas9-mediated mosaic mutation of SRY gene induces hermaphroditism in rabbits.

  2. our study demonstrates that Sp1 is a major regulator in SRY gene transcription, and mutations of the Sp1 binding sites (Sp1-B and Sp1-C) in the 5' flanking region of SRY induce sex reversal in rabbits

  3. Gene conversion is a general feature of the evolution of the mammalian Y chromosome.

Mouse (Murine) Sex Determining Region Y (SRY) interaction partners

  1. Activation of SRY and its downstream Sox9 and PDGFRalpha pathways are commonly involved in male hepatocarcinogenesis, which provides novel insights into gender disparity and sex-specific therapeutic strategies of hepatocellular carcinoma.

  2. MAP2K6 functions in mouse testis determination, via positive effects on Sry, and a minor role for MAP2K3.

  3. our findings support that males lacking the testis determinant Sry can be fertile and reinforce the notion that Sry does not play a role in mature gonads.

  4. Variations in Usp9y and the number of CAG repeats in Sry are significantly associated with testes weight.

  5. Sry can be replaced by transgenic activation of its downstream target Sox9. This finding supports the existence of functional redundancy between the Y chromosome genes and their homologs encoded on other chromosomes.

  6. SRY binds to various ovarian differentiation genes and represses their activation through WNT/beta-catenin signaling.

  7. The SRY gene in plasma extracellular vesicles transferred to vascular endothelial cells may play an important role in the pathogenesis of atherosclerosis

  8. Studies indicate that in most of mammals, a single genetic trigger, the Y-linked gene Sry (sex determination region on Y chromosome), regulates testicular differentiation.

  9. disprove the hypothesis that the conserved HMG box domain is the only functional domain of Sry, and highlight an evolutionary paradox whereby mouse Sry has evolved a novel bifunctional module to activate Sox9 directly

  10. this study demonstrates that live mouse progeny can also be generated by using germ cells from males with the Y chromosome contribution limited to only two genes, the testis determinant factor Sry and the spermatogonial proliferation factor Eif2s3y.

  11. Microsatellite-encoded domain in rodent Sry functions as a genetic capacitor to enable the rapid evolution of biological novelty.

  12. 70-kDa heat shock cognate protein hsc70 mediates calmodulin-dependent nuclear import of the sex-determining factor SRY.

  13. Data from knockout mice suggest that spermiogenesis can be initiated whether or not second meiotic division has taken place, and even when the only Y genes present are Sry and Eif2s3y.

  14. mice lacking Gadd45gamma also exhibit XY gonadal sex reversal caused by disruption to Sry expression

  15. suggest that a signaling cascade, involving GADD45G --> p38 MAPK --> GATA4 --> SRY, regulates male sex determination

  16. Data propose that SRY/Sry may function as a male-specific maturation factor in the peri-implantation mammalian embryo.

  17. Data suggest a mechanism by which SRY induces Sox9 and Er71 transcription early in testis differentiation.

  18. Factor SRY is the key trigger of mammalian sex determination by means of initiation the autosomal gene SOX9 expression. (Review)

  19. This study implicates Cbx2 in testis differentiation through regulating Sry gene expression.

  20. The results of this study suggest that gender indeed influences several PD-related gene expressions in VM neurons, and SRY and estrogen are involved in the different responses to oxidative stress in culture.

Sex Determining Region Y (SRY) Antigen Profile

Protein Summary

This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome)\; translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome.

Gene names and symbols associated with SRY

  • sex determining region Y (SRY) antibody
  • sex determining region Y (Sry) antibody
  • sex determining region of Chr Y (Sry) antibody
  • SRXX1 antibody
  • SRXY1 antibody
  • SRY antibody
  • Sry1 antibody
  • Sry3BI antibody
  • SRYGENE antibody
  • Tdf antibody
  • Tdy antibody

Protein level used designations for SRY

essential protein for sex determination in human males , sex-determining region Y protein , sex-determining region on Y , testis-determining factor on Y , HMG box transcription factor Sry1 , HMG box transcription factor Sry3BI , Testis determining locus , sex determining region of Chr Y , sex determining region on Y , testis-determining factor , sex determining factor Y , sex-determining region of the Y-chromosome , sex determining region Y protein , sex-determining protein , sex determining region Y , testis determining-Y , Sex-determining region Y protein , Testis-determining factor , sex determining region Y variant A , sex determining region Y variant B , testis determining factor , sex determining factor SRY , testis determining factor SRY

GENE ID SPECIES
6736 Homo sapiens
25221 Rattus norvegicus
280931 Bos taurus
407740 Sus scrofa
449510 Pan troglodytes
493758 Felis catus
574155 Macaca mulatta
100033824 Equus caballus
100328958 Oryctolagus cuniculus
21674 Mus musculus
100529253 Ovis aries
108634533 Capra hircus
109555752 Bos indicus
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