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This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. Additionally we are shipping Sex Determining Region Y Proteins (44) and Sex Determining Region Y Kits (17) and many more products for this protein.
Showing 10 out of 89 products:
Human Monoclonal SRY Primary Antibody for FACS, IHC - ABIN1098106
Peng, Ivanov, Oh, Lau, Rauscher: Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery. in The Journal of biological chemistry 2009
Show all 2 Pubmed References
Activation of SRY and its downstream Sox9 (show SOX9 Antibodies) and PDGFRalpha pathways are commonly involved in male hepatocarcinogenesis, which provides novel insights into gender disparity and sex-specific therapeutic strategies of hepatocellular carcinoma.
a single-nucleotide polymorphism in the amelogenin (show AMELX Antibodies) gene using amplified product-length polymorphisms in combination with sex-determining region Y analysis, is reported.
Missense Mutation 224G>T (R75M) in SRY Coding Region is associated with 46, XY Gonadal Dysgenesis.
Chemical proteasome inhibition restored native-like SRY expression and transcriptional activity in association with restored occupancy of a sex-specific enhancer element in principal downstream gene Sox9 (show SOX9 Antibodies), demonstrating that the variant SRY exhibits essentially native activity on a per molecule basis.
SRY is involved in the maintenance of cancer stem-like characteristics through OCT4 (show POU5F1 Antibodies).
The aim of this study was to compare two Y chromosome markers-SRY and DYS14-for their utility in the diagnosis of fetal gender
These findings demonstrate that autosomal retention of SRY can be sub-microscopic and emphasize the importance of PCR and FISH in the genetic workup of the monosomic X male
The SRY gene in plasma extracellular vesicles transferred to vascular endothelial cells may play an important role in the pathogenesis of atherosclerosis
Results show that SRY could be expressed in tissues of Hirschsprung patients. It binds to the promoter of RET (show RET Antibodies) gene by competing with SOX10 (show SOX10 Antibodies) for its interaction with PAX3 (show PAX3 Antibodies) and NKX2-1 (show NKX2-1 Antibodies) repressing their transcriptional expression and RET's as well.
High levels of SRY expression correlated with cancer progression and poor HCC (show FAM126A Antibodies) patient survival. However, high SRY levels are not significantly correlated with HCC (show FAM126A Antibodies) sex bias.
analysis of mtDNA control region sequences and SRY gene sequences indicated more contribution to the Yunnan cattle from B. indicus than from B. taurus
New insights into SRY regulation through identification of 5' conserved sequence are reported.
The 4.6 Kb of pig SRY 5' flanking sequences supported reporter transgene expression within the male genital ridge but not within the neural crest.
This case represents the first report of an SRY negative XX-male sex reversal intersex phenotype, which is a potentially inherited condition, in an American saddlebred horse.
our study demonstrates that Sp1 (show SP1 Antibodies) is a major regulator in SRY gene transcription, and mutations of the Sp1 (show SP1 Antibodies) binding sites (Sp1 (show SP1 Antibodies)-B and Sp1 (show SP1 Antibodies)-C) in the 5' flanking region of SRY induce sex reversal in rabbits
MAP2K6 (show MAP2K6 Antibodies) functions in mouse testis determination, via positive effects on Sry, and a minor role for MAP2K3 (show MAP2K3 Antibodies).
our findings support that males lacking the testis determinant Sry can be fertile and reinforce the notion that Sry does not play a role in mature gonads.
Variations in Usp9y (show USP9Y Antibodies) and the number of CAG repeats in Sry are significantly associated with testes weight.
Sry can be replaced by transgenic activation of its downstream target Sox9 (show SOX9 Antibodies). This finding supports the existence of functional redundancy between the Y chromosome genes and their homologs encoded on other chromosomes.
SRY binds to various ovarian differentiation genes and represses their activation through WNT (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling.
Studies indicate that in most of mammals, a single genetic trigger, the Y-linked gene Sry (sex determination region on Y chromosome), regulates testicular differentiation.
disprove the hypothesis that the conserved HMG (show SSRP1 Antibodies) box domain is the only functional domain of Sry, and highlight an evolutionary paradox whereby mouse Sry has evolved a novel bifunctional module to activate Sox9 (show SOX9 Antibodies) directly
this study demonstrates that live mouse progeny can also be generated by using germ cells from males with the Y chromosome contribution limited to only two genes, the testis determinant factor Sry and the spermatogonial proliferation factor Eif2s3y.
This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome)\; translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome.
essential protein for sex determination in human males
, sex-determining region Y protein
, sex-determining region on Y
, testis-determining factor on Y
, HMG box transcription factor Sry1
, HMG box transcription factor Sry3BI
, Testis determining locus
, sex determining region of Chr Y
, sex determining region on Y
, testis-determining factor
, sex determining factor Y
, sex-determining region of the Y-chromosome
, sex determining region Y protein
, sex-determining protein
, sex determining region Y
, testis determining-Y
, Sex-determining region Y protein
, Testis-determining factor
, sex determining region Y variant A
, sex determining region Y variant B
, testis determining factor
, sex determining factor SRY
, testis determining factor SRY