Siah E3 Ubiquitin Protein Ligase 2 (SIAH2) ELISA Kits

SIAH2 encodes a protein that is a member of the seven in absentia homolog (SIAH) family. Additionally we are shipping SIAH2 Antibodies (66) and SIAH2 Proteins (7) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
SIAH2 6478 O43255
SIAH2 20439 Q06986
SIAH2 140593 Q8R4T2
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More ELISA Kits for SIAH2 Interaction Partners

Human Siah E3 Ubiquitin Protein Ligase 2 (SIAH2) interaction partners

  1. the Siah2-PHD3- HIF-1alpha (show HIF1A ELISA Kits)-VEGF (show VEGFA ELISA Kits) axis is an important hypoxic signaling pathway in a leukemic microenvironment.

  2. Based on the proposition that NS5 (show RAF1 ELISA Kits) utilizes SIAH2-mediated proteasomal degradation of STAT2 (show STAT2 ELISA Kits), an in-silico study was carried out to characterize the protein-protein interactions between NS5 (show RAF1 ELISA Kits), SIAH2 and STAT2 (show STAT2 ELISA Kits) proteins.

  3. The crystallographic models provide structural insights into the substrate binding of the SIAH family E3 ubiquitin ligases that are critically involved in regulating cancer-related pathways.

  4. Study identified SIAH1 (show SIAH1 ELISA Kits)/2 (SIAH (show SIAH1 ELISA Kits)) as the E3 ligase mediating Wnt (show WNT2 ELISA Kits)-induced Axin (show AXIN1 ELISA Kits) degradation. SIAH (show SIAH1 ELISA Kits) proteins promote the ubiquitination and proteasomal degradation of Axin (show AXIN1 ELISA Kits) through interacting with a VxP motif in the GSK3-binding domain of Axin (show AXIN1 ELISA Kits), and this function of SIAH (show SIAH1 ELISA Kits) is counteracted by GSK3 binding to Axin (show AXIN1 ELISA Kits).

  5. SIAH2 regulates CHK2 (show CHEK2 ELISA Kits) basal turnover, with important consequences on cell-cycle control and on the ability of hypoxia to alter the DNA damage-response pathway in cancer cells.

  6. study revealed an interesting mutual regulation between Plk3 (show PLK3 ELISA Kits) and SIAH2 and uncovered a regulatory network that functions to fine-tune the cellular hypoxic response.

  7. ETS2 (show ETS2 ELISA Kits) and Twist1 (show TWIST1 ELISA Kits) promote invasiveness of Helicobacter pylori-infected gastric cancer cells by inducing Siah2

  8. Manipulation of SIAH2 expression led to a 'cross-talk' of the ERK and PI3K pathway.

  9. Siah-2 expression was observed in 29.3% of oral squamous cell carcinoma. Siah-2 was located in the cytoplasm and cell membranes.

  10. SIAH2 is associated with a tumor promoting role in breast cancer.

Xenopus laevis Siah E3 Ubiquitin Protein Ligase 2 (SIAH2) interaction partners

  1. Over-expression of xSiah2 decreased PHD45 but not PHD28 and caused the small-eye phenotype of Xenopus

Mouse (Murine) Siah E3 Ubiquitin Protein Ligase 2 (SIAH2) interaction partners

  1. The results suggest that SIAH2 plays a pivotal role to promote Th17 cell differentiation through maintaining the stability of HIF-1alpha (show HIF1A ELISA Kits) protein.

  2. High Siah2 expression is associated with increased adipogenesis.

  3. Siah2(-/-) endothelial cells have an intact hypoxic signalling pathway, including Hif-1alpha (show HIF1A ELISA Kits) stabilisation and gene expression, the first report of a tissue or cell lineage in which the loss of Siah2 does not seem to impact hypoxic response signaling.

  4. Siah2 links adipocyte hypertrophy with adipocyte dysfunction and recruitment of proinflammatory immune cells to adipose tissue.

  5. A catalysis-independent role for AKR1C3 (show AKR1C3 ELISA Kits) on AR activity via Siah2 has been identified.

  6. Combination of netrin-1 and SIAH RNAi may prove to be a substantially effective therapy for myocardial infarction.

  7. Siah1/2 constitutes an obligatory fine-tuning mechanism that predisposes cells to death under severe ER stress conditions

  8. our studies demonstrate the role of Siah2 in regulation of tight junction integrity and cell polarity under hypoxia, through its regulation of ASPP2 (show TP53BP2 ELISA Kits) stability.

  9. Blood vessel normalization in Siah2(-/-) tumors resulted in an increased response to chemotherapy and prolonged survival

  10. modulation of PPARgamma (show PPARG ELISA Kits) protein levels by the ubiquitin ligase Siah2 is essential in determining the physiological effects of PPARgamma (show PPARG ELISA Kits) activation in adipocytes

SIAH2 Antigen Profile

Antigen Summary

This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia.

Gene names and symbols associated with SIAH2

  • siah E3 ubiquitin protein ligase 2 (SIAH2) antibody
  • siah E3 ubiquitin protein ligase 2 L homeolog (siah2.L) antibody
  • seven in absentia 2 (Siah2) antibody
  • siah E3 ubiquitin protein ligase 2 (Siah2) antibody
  • AA415433 antibody
  • hSiah2 antibody
  • siah2-A antibody
  • Sinh2 antibody
  • Xsiah-2 antibody
  • xsiah2 antibody

Protein level used designations for SIAH2

E3 ubiquitin-protein ligase SIAH2 , seven in absentia homolog 2 , siah-2 , seven in absentia-like protein , E3 ubiquitin-protein ligase siah2 , mSiah2 , seven in absentia 2

6478 Homo sapiens
429164 Gallus gallus
785659 Bos taurus
100034000 Equus caballus
100622531 Sus scrofa
373622 Xenopus laevis
20439 Mus musculus
140593 Rattus norvegicus
100683719 Canis lupus familiaris
100718979 Cavia porcellus
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