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SPPL2B encodes a member of the GXGD family of aspartic proteases.
Showing 9 out of 9 products:
Cow (Bovine) Polyclonal SPPL2B Primary Antibody for IHC, WB - ABIN2782090
Del Campo, Hoozemans, Dekkers, Rozemuller, Korth, Müller-Schiffmann, Scheltens, Blankenstein, Jimenez, Veerhuis, Teunissen: BRI2-BRICHOS is increased in human amyloid plaques in early stages of Alzheimer's disease. in Neurobiology of aging 2014
SPPL2b is targeted through the secretory pathway to endosomes/lysosomes, whereas SPP (show HM13 Antibodies) and SPPL3 (show SPPL3 Antibodies) are restricted to the ER.
TfR1 (show TFRC Antibodies) N-terminal fragment is a substrate for intramembrane proteolysis by SPPL2b.
The alpha-helical content of the transmembrane domain of the British dementia protein-2 (Bri2 (show ITM2B Antibodies)) determines its processing by signal peptide peptidase-like 2b (SPPL2b).
SPP, SPPL2a (show SPPL2A Antibodies), -2b, -2c, and -3 probably cleave type II-oriented substrate peptides as shown by consensus analysis
SPPL2b is targeted through the secretory pathway to endosomes/lysosomes, whereas SPP and SPPL3 (show SPPL3 Antibodies) are restricted to the ER.
Results demonstrate that SPPL2b utilizes multiple intramembrane cleavages to liberate the intracellular domain of tumor necrosis factor alpha (show TNF Antibodies) into the cytosol.
SPPL2a (show SPPL2A Antibodies) and SPPL2b mediate the intramembrane cleavage, whereas neither SPP nor SPPL3 (show SPPL3 Antibodies) is capable of processing the Bri2 (show ITM2B Antibodies) N-terminal fragment.
Alzheimer disease-like mutant SPPL2b slowed intramembrane proteolysis of tumor necrosis factor alpha (show TNF Antibodies) and caused a relative increase of longer intracellular cleavage products.
in vivo SPPL2a (show SPPL2A Antibodies), but not SPPL2b, exhibit a physiologically relevant contribution to CD74 (show CD74 Antibodies) proteolysis in B and dendritic cells
This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene.
signal peptide peptidase-like 2B
, signal peptide peptidase-like protein 2
, SPP-like 2B
, protein SPP-like 2B
, protein SPPL2b
, intramembrane protease 4
, presenilin homologous protein 4
, presenilin-like protein 1