SPPL2B antibody (AA 196-229)

Catalog No. ABIN6243975

The Rabbit Polyclonal anti-SPPL2B antibody is suitable to detect SPPL2B in samples from Human. It has been validated for WB.

Quick Overview for SPPL2B antibody (AA 196-229) (ABIN6243975)

Target: SPPL2B (Signal Peptide Peptidase-Like 2B (SPPL2B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPPL2B antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB53139

Product Details anti-SPPL2B Antibody

Binding Specificity: AA 196-229

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SPPL2B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 196-229 amino acids from the Central region of human SPPL2B.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for SPPL2B

Target: SPPL2B (Signal Peptide Peptidase-Like 2B (SPPL2B))

Alternative Name: SPPL2B

Background: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF- alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. May play a role in the regulation of innate and adaptive immunity.

Molecular Weight: 64644

UniProt: Q8TCT7