Signaling Lymphocytic Activation Molecule Family Member 1 Proteins (SLAMF1)

High-affinity self-ligand important in bidirectional T- cell to B-cell stimulation. Additionally we are shipping SLAMF1 Antibodies (221) and SLAMF1 Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLAMF1 27218 Q9QUM4
SLAMF1 6504 Q13291
SLAMF1 498286  
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Top SLAMF1 Proteins at antibodies-online.com

Showing 10 out of 24 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Human Cells Human His tag 100 μg 14 to 16 Days
$440.65
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg 50 to 55 Days
$5,262.31
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,749.58
Details
Human Cells Rat His tag 100 μg 14 to 16 Days
$440.65
Details
Escherichia coli (E. coli) Human His tag,T7 tag 100 μg 15 to 18 Days
$672.00
Details
Human Cells Human His tag   50 μg 4 Days
$269.50
Details
Escherichia coli (E. coli) Human His tag 100 μg 15 to 19 Days
$1,107.69
Details
Baculovirus infected Insect Cells Human His tag 50 μg 13 to 16 Days
$553.85
Details
Wheat germ Human GST tag 10 μg 11 to 12 Days
$414.29
Details
Human Cells Human His tag   10 μg 15 to 16 Days
$175.00
Details

SLAMF1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
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Rat (Rattus) ,
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More Proteins for Signaling Lymphocytic Activation Molecule Family Member 1 (SLAMF1) Interaction Partners

Mouse (Murine) Signaling Lymphocytic Activation Molecule Family Member 1 (SLAMF1) interaction partners

  1. the Slam locus has an overall inhibitory role during NK cell activation that is solely dependent on 2B4. This effect is influenced by cytokines and leads to suppression of LFA-1 activity.

  2. CRISPR-Mediated Slamf1Delta/Delta Slamf5Delta/Delta Slamf6Delta/Delta Triple Gene Disruption Reveals NKT Cell Defects but Not T Follicular Helper Cell Defects.

  3. We demonstrated that Bacille Calmette-Guerin infection significantly upregulated SLAMF1, which enhanced inflammatory response by activating the NF-kappaB signaling pathway and facilitated bacterial clearance in BCG-infected RAW264.7 cells and mice.

  4. Slamf1 and Slamf8 govern ROS-dependent innate immune responses of myeloid cells.

  5. The combined effects of RIIB deletion and pathogenic SLAM can lead to severe lupus nephritis in the B6 genetic background.

  6. SLAM-SAP signaling promotes differentiation of IL-17-producing T cells and progression of experimental autoimmune encephalomyelitis.

  7. The goal of the current study was to determine whether Slam haplotype affected NKT and Vgamma4+ T-cell responses subsequent to coxsackievirus b3 infection.

  8. Signaling lymphocyte activation molecule regulates development of colitis in mice.

  9. Slamf1, which controls phagosomal/lysosomal fusion and phagosomal NADPH-oxidase activity, is required for T.cruzi replication in macrophages and dendritic cells, but not in other cells, which do not express the receptor.

  10. conclude that Slamf1 recruits a subset of Vps34-associated proteins, which is involved in membrane fusion and NOX2 regulation

  11. Slamf1 is a bacterial sensor that regulates intracellular enzyme activities involved in the removal of Gram-negative bacteria.

  12. SLAM signaling drives most of (interleukin) IL-4 production by germinal center T follicular helper CD4 cells.

  13. Polymorphisms that distinguish two Slam haplotypes significantly modulate the innate immune response in vivo through their effect on natural killer T (NKT) cells.

  14. role of SAP in murine antigen-mediated T-cell proliferation and interferon gamma production

  15. Coreceptor SLAM plays a central role at the interface of acquired and innate immune responses.

  16. Cell surface receptors of the SLAM family, including CD150, CD244, and CD48, were differentially expressed among functionally distinct hematopoietic progenitor cells.

  17. SLAM/SLAM interactions inhibit CD40-induced signal transduction in monocyte-derived dendritic cells.

  18. Data show that the interaction of the FynT SH3 domain with SLAM-SAP is strictly inducible, and is dependent on engagement of SLAM by extracellular ligands.

  19. control of NKT cell numbers attributed to the Nkt1 gene is mediated by differential expression of Slamf1 and an additional contribution by Slamf6.

  20. Both CD150(+) and CD150(-) cells can be found within the stem cell population population and both populations can contribute to long-term multilineage reconstitution.

Human Signaling Lymphocytic Activation Molecule Family Member 1 (SLAMF1) interaction partners

  1. SLAMF1 ligation in a human peripheral blood T cell-B cell culture system reduced the following in both healthy controls and patients with SLE: conjugate formation, interleukin-6 (IL-6) production by B cells, IL-21 and IL-17A production by T cells, and Ig and autoantibody production.

  2. SLAMF1 is required for TLR4-mediated TRAM-TRIF-dependent signaling in human macrophages.

  3. CD150 and CD180 receptors may modulate transcriptional program in lymphocytic leukemia cells by regulating the transcription factor expression levels

  4. this paper shows that the X-linked lymphoproliferative disease gene product SAP regulates signals induced through the co-receptor SLAM

  5. combination of signals via CD150 and CD180 leads to blocking of pro-survival pathways that may be a restraining factor for neoplastic CLL B cells propagation in more than 50% of CLL cases where these receptors are coexpressed

  6. EBF1 is critical for transcriptional control of SLAMF1 gene in human B cells.

  7. MeV can hijack SLAMF1 to drive endocytosis using a complex pathway that shares features with canonical viral macropinocytosis, phagocytosis, and mechanotransduction. This uptake pathway is specific to SLAMF1-positive cells and occurs within 60 min of viral attachment.

  8. Malignant B-cell lines at the different stages of maturation only partially resemble their normal counterparts by CD150 expression. In malignant B-cell lines, CD150 expression on mRNA level is much broader than on protein level. CD150 isoforms are differentially expressed in normal and malignant B cells with predominant expression of mCD150 isoform.

  9. Data suggest that SLAMF1 is another significant piece in the intricate defective immune-regulatory function of patients with SLE.

  10. results indicate that loss of SLAMF1 expression in chronic lymphocytic leukemia modulates genetic pathways

  11. Upstream open reading frames regulate translation of the long isoform of SLAMF1 mRNA that encodes costimulatory receptor CD150

  12. Molecular dynamics analysis revealed that mutant R32Q and T53I structures of SAP exhibited structural variation with respect to their backbone atoms before and after binding with the unphosphorylated SLAM peptide.

  13. Signaling lymphocytic activation molecule (SLAM)/SLAM-associated protein pathway regulates human B-cell tolerance.

  14. Latent membrane protein 1 was responsible for the CD150 upregulation.

  15. Experimental adaptation of wild-type canine distemper virus (CDV) to the human entry receptor CD150

  16. Two genes were consistently retained in the models with clinical variables: SKI (v-SKI avian sarcoma viral oncogene homolog) and SLAMF1 (signaling lymphocytic activation molecule family member 1; CD150).

  17. conclude that Slamf1 recruits a subset of Vps34-associated proteins, which is involved in membrane fusion and NOX2 regulation

  18. HIV-1 infection induces a high level of SLAM expression on CD4(+) T cells, which may enhance their susceptibility to measles virus and exacerbate measles in coinfected individuals.

  19. the study demonstrates that variants of SLAMF1 and ITLN1, both implicated in inflammation, are associated with type 2 diabetes in Indians.

  20. Subjects previously immunized with measles-mumps-rubella vaccine were genotyped for 66 candidate single nucleotide polymorphisms in the CD46, SLAM and CD209 genes.

SLAMF1 Protein Profile

Protein Summary

High-affinity self-ligand important in bidirectional T- cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.

Gene names and symbols associated with SLAMF1

  • signaling lymphocytic activation molecule family member 1 (SLAMF1)
  • signaling lymphocytic activation molecule family member 1 (Slamf1)
  • 4933415F16 protein
  • AA177906 protein
  • CD150 protein
  • CDw150 protein
  • ESTM51 protein
  • IPO-3 protein
  • RGD1560634 protein
  • Slam protein
  • SLAMF1 protein

Protein level used designations for SLAMF1

signaling lymphocyte activation molecule , signaling lymphocytic activation molecule , signaling lymphocytic activation molecule family member 1 , IPO-3

GENE ID SPECIES
678672 Ovis aries
100351513 Oryctolagus cuniculus
425300 Gallus gallus
457436 Pan troglodytes
100597501 Nomascus leucogenys
27218 Mus musculus
6504 Homo sapiens
498286 Rattus norvegicus
403642 Canis lupus familiaris
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