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The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics.
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A PLCbeta/PI3Kgamma (show PIK3CG Antibodies)-GSK3 signaling pathway regulates cofilin (show CFL1 Antibodies) phosphatase slingshot2 and neutrophil polarization and chemotaxis.
Novel signaling pathway consisting of chemoattractant GPCR/Galphai protein, PLC, PKCbeta and PKDs that regulates SSH2/cofilin activity, F-actin polymerization and directional assembly of actin cytoskeleton in neutrophil chemotaxis was identified.
data indicate that: (a) apoptotic cell death in FLCN (show FLCN Antibodies)-null cells can be triggered by SSH2 knockdown through cell cycle arrest; (b) SSH2 represents a potential therapeutic target for the development of agents for the treatment of BHD (show FLCN Antibodies) syndrome related tumors
Expression of phosphatase-dead versions of SSH proteins, SSH1 (show SSH1 Antibodies), SSH2 & SSH3 (show SSH3 Antibodies) results in phosphorylation/inactivation of cofilin (show CFL1 Antibodies), changes in cytoskeleton organization, loss of cell polarity, and assembly of aberrant arrays of laminin-332 in keratinocytes.
The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1\; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002
, SSH-like protein 2
, protein phosphatase Slingshot homolog 2
, slingshot 2L
, slingshot-like 2