anti-Small Proline Rich Protein 2A (SPRR2A) Antibodies

Human Small Proline Rich Protein 2A (SPRR2A) interaction partners

1. Expression of SPRR1 (show SPRR1B Antibodies) and of SPRR2A is increased in mucosal samples from patients with chronic rhinosinusitis and appeared as a downstream result of TNF alpha (show TNF Antibodies) modulation, which possibly resulted in epithelial barrier dysfunction.

2. SPRR2a modulates ZEB-1 (show ZEB1 Antibodies) signaling by way of miR (show MLXIP Antibodies)-200c/141-associated epithelial mesenchyme transition through SH3-domain (show ITSN1 Antibodies) networks and contributes to benign and malignant wound-healing responses.

3. SPRR2A-associated tumor behavior was mimicked by MUC1 (show MUC1 Antibodies) shRNA, which induced EMT (show ITK Antibodies) and, like SPRR2A+ cells, showed reduced metastatic capabilities

4. SPRR2A functions as a suppressor of p53 (show TP53 Antibodies)-dependent transcriptional activity, which otherwise might impede cellular processes needed for epithelial wound repair responses.

5. Association of psoriasis to PGLYRP (show PGLYRP1 Antibodies) and SPRR (show SPRR1A Antibodies) genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families.

6. Small proline-rich proteins (SPRR2A) function as SH3 domain (show ITSN1 Antibodies) ligands, increase resistance to injury and are associated with epithelial-mesenchymal transition (EMT (show ITK Antibodies)) in cholangiocytes.

Mouse (Murine) Small Proline Rich Protein 2A (SPRR2A) interaction partners

1. Sprr2a is selectively expressed in the upper layer of the epithelium surrounding taste buds in the circumvallate papilla

2. Immunohistochemical staining revealed that Sprr2a protein is detected only in the adult uterus, and not in the ovary, oviduct or testis.

3. In non-lesional HPV8-CER (show CBLN1 Antibodies) transgenic skin StefinA and Sprr2 are indirect/direct transcriptional targets of HPV8

4. Data show that SPRR2a and b are allergen- and IL-13 (show IL13 Antibodies)-induced in experimental allergic responses that may be involved in disease pathophysiology.

5. Small proline-rich proteins (SPRR2A) function as SH3 domain (show ITSN1 Antibodies) ligands, increase resistance to injury and are associated with epithelial-mesenchymal transition (EMT (show ITK Antibodies)) in cholangiocytes.