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Overexpression causes the formation of large vacuoles that seemed to be derived from the endoplasmic reticulum.. Additionally we are shipping SVIP Proteins (5) and and many more products for this protein.
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overexpression of gp78 (show AMFR ELISA Kits) or SVIP suppression may eliminate the toxic gain of function associated with polymerization of ZAAT, thus providing a potential new therapeutic approach to the treatment of alpha-1 antitrypsin (show SERPINA1 ELISA Kits) deficiency
the interactions between P97 (show EIF4G2 ELISA Kits) and these motifs, including VCP (show vcp ELISA Kits)-binding motif (VBM) and VCP (show vcp ELISA Kits)-interacting motif (VIM (show VIM ELISA Kits)). The solution structures of the VBM motif from HRD1 (show SYVN1 ELISA Kits) and the VIM (show VIM ELISA Kits) motif from SVIP are both comprised mainly of a single alpha-helix.
A major portion of SVIP is intrinsi (show vcp ELISA Kits)cally disordered in solution.
SVIP plays a regulatory role in p97 (show EIF4G2 ELISA Kits) subcellular localization and is a novel regulator of autophagy.
SVIP is an endogenous inhibitor of ERAD that acts through regulating the assembly of the gp78 (show AMFR ELISA Kits)-p97/VCP (show vcp ELISA Kits)-Derlin1 (show DERL1 ELISA Kits) complex.
SVIP and valosin containing protein (show vcp ELISA Kits) were seen to be co-localized in neuronal cell bodies.
Overexpression causes the formation of large vacuoles that seemed to be derived from the endoplasmic reticulum.