Snail Family Zinc Finger 2 Proteins

Protein Summary

Transcriptional repressor that modulates both activator- dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1- induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Represses BRCA2 expression by binding to its E2-box- containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis (By similarity). {ECO:0000250}.

Gene names and symbols associated with SNAI2

• snail family transcriptional repressor 2 (Snai2) antibody
• snail family zinc finger 2 (Snai2) antibody

• Slug antibody
• Slugh antibody
• Snail2 antibody

Protein level used designations for SNAI2

Neural crest transcription factor Slug , Protein snail homolog 2 , Slug, chicken homolog , neural crest transcription factor Slug , protein snail homolog 2 , snail family zinc finger 2 , snail homolog 2 , zinc finger protein SNAI2 , slug, chicken homolog