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SHOC2 encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. Additionally we are shipping Soc-2 Suppressor of Clear Homolog (C. Elegans) Antibodies (59) and many more products for this protein.
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Results provide evidence that SHOC2 trapping at different subcellular sites has a diverse impact on ERK (show EPHB2 Proteins) signaling strength and dynamics, suggesting a dual counteracting modulatory role of SHOC2 in the control of ERK (show EPHB2 Proteins) signaling exerted at different intracellular compartments.
Data suggest that SUR-8 may act in an ERK (show EPHB2 Proteins)-independent pathway to regulate AVC development.
Erbin (show ERBB2IP Proteins) has a regulatory role in the Ras-Raf (show RAF1 Proteins)-MEK (show MDK Proteins) pathway and may inhibit ERK (show EPHB2 Proteins) activation by disrupting the Sur-8-Ras/Raf (show RAF1 Proteins) interaction
Overexpression or knockdown of Sur8 increases or decreases, respectively, the proliferation or transformation of colorectal cancer (CRC (show CALR Proteins)) cell lines. Sur8 knockdown attenuates the migration and invasion of HCT116 CRC (show CALR Proteins) cells.
results demonstrate that PSMC5 (show PSMC5 Proteins) is a new and important player involved in regulating ERK1/2 signal transmission through the remodeling of Shoc2 scaffold complex in a spatially-defined manner.
Noonan-like syndrome has been related to the invariant c.4A > G missense change in SHOC2.
Two unrelated Taiwanese patients have been described with Noonan-like syndrome with loose anagen hair who also have moyamoya disease and in whom heterozygous germline mutation in SHOC2 was found.
ectopic overexpression of human Shoc2 in PC12 cells significantly promotes neurite extension in the presence of Epidermal Growth Factor (show EGF Proteins), a stimulus that induces proliferation rather than differentiation in these cells.
Extreme phenotypic variability associated with the invariant SHOC2 c.4A>G (p.Ser2Gly) missense mutation in Noonan-like syndrome with loose anagen hair.
A newborn heterozygous for the invariant c.4A>G missense change in SHOC2.
Data show that both Shoc2 and HUWE1 (show HUWE1 Proteins) are necessary to control the levels and ubiquitination of the Shoc2 signaling partner, RAF-1 (show RAF1 Proteins).
Both MRAS (show MRAS Proteins) and SHOC2 play a key role in polarized migration.
This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair.
Ras-binding protein SUR-8
, leucine-rich repeat protein SHOC-2
, protein soc-2 homolog
, protein sur-8 homolog
, suppressor of clear, C. elegans, homolog of
, Protein soc-2 homolog
, Protein sur-8 homolog