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SCNM1 is a zinc finger protein and putative splicing factor.
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Variation between inbred strains of mice can be used to identify modifier genes affecting the susceptibility to inherited disease. The severity of the neurological disorder is determined by the modifier locus Scnm1.
Scnm1 is the first example of a modifier gene which influences disease severity through a trans-effect on splicing of the disease gene transcript.
This locus represents naturally occurring read-through transcription between the neighboring TNFAIP8L2 (tumor necrosis factor, alpha-induced protein 8-like 2) and SCNM1 (sodium channel modifier 1) genes on chromosome 1. The protein-coding read-through transcript variant encodes a protein that shares sequence identity with the downstream gene product but its N-terminal region is shorter due to alternate exon use relative to the downstream gene.
sodium channel modifier 1, pseudogene
, sodium channel modifier 1
, Sodium channel modifier 1
, TNFAIP8L2-SCNM1 protein