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SLC12A4 encodes a member of the SLC12A transporter family. Additionally we are shipping Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 4 Proteins (6) and and many more products for this protein.
Showing 10 out of 48 products:
Human Polyclonal SLC12A4 Primary Antibody for ELISA, IHC (p) - ABIN451604
Simard, Bergeron, Frenette-Cotton, Carpentier, Pelchat, Caron, Isenring: Homooligomeric and heterooligomeric associations between K+-Cl- cotransporter isoforms and between K+-Cl- and Na+-K+-Cl- cotransporters. in The Journal of biological chemistry 2007
Human Polyclonal SLC12A4 Primary Antibody for ELISA, IHC - ABIN238576
Wei, Akerman, Newey, Pan, Clinch, Jacob, Shen, Wilkins, Ellory: The potassium-chloride cotransporter 2 promotes cervical cancer cell migration and invasion by an ion transport-independent mechanism. in The Journal of physiology 2011
Show all 2 Pubmed References
data indicate that Zn(2+) acting via ZnR/GPR39 (show GPR39 Antibodies) has a direct role in controlling Cl(-) absorption via upregulation of basolateral KCC1 in the colon. Moreover, colonocytic ZnR/GPR39 (show GPR39 Antibodies) and KCC1 reduce water loss during diarrhea and may therefore serve as effective drug targets.
The Wnk3 (show WNK3 Antibodies) protein isoforms have a similar effect on SLC12 cotransporters. NKCC1 (show SLC12A2 Antibodies)/2 and NCC (show SLC12A3 Antibodies) were inhibited, even in hypertonicity, while KCCs were activated, even in isotonic conditions.
Insulin (show INS Antibodies)-like growth factors I can induce the upregulation of KCC1 gene, and KCC1 gene participates in the invasion ability of HEC (show NDC80 Antibodies)-1B cells through the ERK (show EPHB2 Antibodies) signaling pathway.
KCC3 (show SLC12A6 Antibodies) is the dominant isoform in erythrocytes, with variable expression of KCC1 and KCC4 (show SLC12A7 Antibodies) that could result in modulation of KCC activity
the KCC1 gene promoter lacks a TATA box and is composed of an initiator element (InR (show INSR Antibodies)) and a downstream promoter element (DPE)
KCC activation by IGF-1 (show IGF1 Antibodies) plays an important role in IGF-1 (show IGF1 Antibodies) signaling to promote growth and spread of gynecological cancers.
IGF-II (insulin-like growth factors-2) can enhance KCC1 (KC1 co-transport-1) gene expression in cervical cancer cells through signal transduction pathways
We show that a single mutant allele of Kcc1 induces widespread sickling and tissue damage, leading to premature death in a humanized mouse model of sickle cell disease
Ste20 (show STK24 Antibodies)-related proline-alanine-rich kinase (SPAK (show STK39 Antibodies)) and oxidative stress response 1 (OSR1 (show OSR1 Antibodies)) with the cotransporters KCC3 (show SLC12A6 Antibodies), NKCC1 (show SLC12A2 Antibodies), and NKCC2 (show SLC12A1 Antibodies) but not KCC1 and KCC4 (show SLC12A7 Antibodies)
Treatment of cells expressing mouse K-Cl cotransporter Kcc1 with several chemical cross-linkers shifted Kcc1 polypeptide to higher MW forms. The N-terminal & C-terminal cytoplasmic tails of Kcc1 were not essential for Kcc1 crosslinking.
This gene encodes a member of the SLC12A transporter family. The encoded protein mediates the coupled movement of potassium and chloride ions across the plasma membrane. This gene is expressed ubiquitously. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
electroneutral potassium-chloride cotransporter 1
, erythroid K-Cl cotransporter 1
, potassium/chloride cotransporter 1
, solute carrier family 12 (potassium/chloride transporters), member 4
, solute carrier family 12 member 4
, K-Cl Co-transporter-1
, K-Cl cotransporter KCC1
, furosemide-sensitive K-Cl cotransporter
, solute carrier family 12, member 4
, K-Cl cotransporter 1
, K-Cl cotransporter 4