anti-Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 6 (SLC12A6) Antibodies

SLC12A6 is a member of the K-Cl cotransporter (KCC) family. Additionally we are shipping Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 6 Proteins (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SLC12A6 691209  
SLC12A6 9990 Q9UHW9
SLC12A6 107723 Q924N4
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Top anti-Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 6 Antibodies at antibodies-online.com

Showing 10 out of 73 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated IHC, ELISA, WB ABIN238578 (0.1µg/ml) staining of Human Heart lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$358.02
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p) Immunohistochemistry: KCC3/SLC12A6 Antibody [NBP1-89282] - Staining of human pancreas shows strong cytoplasmic positivity in exocrine pancreas. Immunocytochemistry/Immunofluorescence: KCC3/SLC12A6 Antibody [NBP1-89282] - Human cell line A-431 shows positivity in cytoplasm & vesicles. Antibody staining is shown in green. 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Human Rabbit Un-conjugated IHC (p), WB SLC12A6 Antibody (N-term) (ABIN656316) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Goat Un-conjugated IHC (p), IHC, ELISA, WB Immunohistochemistry-Paraffin: KCC3/SLC12A6 Antibody [NBP1-06044] - (2.5ug/ml) staining of paraffin embedded Human Heart. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Western Blot: KCC3/SLC12A6 Antibody [NBP1-06044] - (0.1ug/ml) staining of Human Heart lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 7 to 9 Days
$485.88
Details
Human Goat Un-conjugated ELISA, WB 100 μg Log in to see 7 to 9 Days
$610.50
Details
Human Rabbit Un-conjugated WB Anti-SLC12A6 antibody, Western blotting Lane 1: HELA Cell Lysate Lane 2: HUT102 Cell Lysate 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (36.01 KDa) . 50 μL Log in to see 11 to 12 Days
$305.71
Details
Human Goat Biotin ELISA, IHC, WB Biotinylated ABIN4902685 (0.1µg/ml) staining of Human Heart lysate (35µg protein in RIPA buffer), exactly mirroring its parental non-biotinylated product. Primary incubation was 1 hour. Detected by chemiluminescence., using streptavidin-HRP and using NAP blocker as a substitute for skimmed milk. 100 μL Log in to see 16 Days
$365.60
Details
Cow Rabbit Un-conjugated WB   100 μg Log in to see 7 to 9 Days
$463.83
Details
Human Goat PE IHC, ELISA, WB   100 μL Log in to see 16 Days
$760.57
Details

SLC12A6 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 6 Antibodies

  1. Human Polyclonal SLC12A6 Primary Antibody for ELISA, WB - ABIN564298 : Salin-Cantegrel, Shekarabi, Holbert, Dion, Rochefort, Laganière, Dacal, Hince, Karemera, Gaspar, Lapointe, Rouleau: HMSN/ACC truncation mutations disrupt brain-type creatine kinase-dependant activation of K+/Cl- co-transporter 3. in Human molecular genetics 2008 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal SLC12A6 Primary Antibody for IHC (p), IHC - ABIN449540 : Simard, Bergeron, Frenette-Cotton, Carpentier, Pelchat, Caron, Isenring: Homooligomeric and heterooligomeric associations between K+-Cl- cotransporter isoforms and between K+-Cl- and Na+-K+-Cl- cotransporters. in The Journal of biological chemistry 2007 (PubMed)

  3. Human Polyclonal SLC12A6 Primary Antibody for ICC, IF - ABIN4328465 : Shiozaki, Takemoto, Ichikawa, Fujiwara, Konishi, Kosuga, Komatsu, Okamoto, Kishimoto, Marunaka, Otsuji: The K-Cl cotransporter KCC3 as an independent prognostic factor in human esophageal squamous cell carcinoma. in BioMed research international 2014 (PubMed)

More Antibodies against Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 6 Interaction Partners

Human Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 6 (SLC12A6) interaction partners

  1. Neurodegenerative deficits in hereditary motor and sensory neuropathy associated with agenesis of the corpus callosum are primarily caused by an axonopathy superimposed upon abnormal development, affecting peripheral but also central nervous system axons, all ultimately because of a genetic defect in the axonal cotransporter KCC3.

  2. These results suggest that the function of the peripheral nervous system depends on finely tuned, kinase-regulated KCC3 activity and implicate abnormal cell volume homeostasis as a previously unreported mechanism of axonal degeneration.

  3. These results suggest that the expression of KCC3 in ESCC may affect cellular invasion and be related to a worse prognosis in patients with ESCC.

  4. SPAK (show STK39 Antibodies) may promote KCC3-mediated cervix tumor aggressiveness via the NF-kappaB (show NFKB1 Antibodies)/p38 MAPK (show MAPK14 Antibodies)/MMP2 (show MMP2 Antibodies) axis.

  5. SLC12A6 has been shown to be causative in Andermann Syndrome.

  6. serine residue 96 of human KCC3 is a third site that has to be dephosphorylated for full activation of the cotransporter during hypotonicity.

  7. mis (show AMH Antibodies)-trafficking of mutant protein is an important pathophysiological feature of HMSN/ACC (show ACACA Antibodies) causative KCC3 mutations.

  8. Neuropathic features of hereditary motor and sensory neuropathy/agenesis of corpus callosum in transgenic mouse lines are predominantly due to a neuronal KCC3 deficit, while the auditory impairment is due to loss of non-neuronal KCC3 expression.

  9. The Wnk3 (show WNK3 Antibodies) protein isoforms have a similar effect on SLC12 cotransporters. NKCC1 (show SLC12A2 Antibodies)/2 and NCC (show SLC12A3 Antibodies) were inhibited, even in hypertonicity, while KCCs were activated, even in isotonic conditions.

  10. KCC3 is the dominant isoform in erythrocytes, with variable expression of KCC1 (show SLC12A4 Antibodies) and KCC4 (show SLC12A7 Antibodies) that could result in modulation of KCC activity

Mouse (Murine) Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 6 (SLC12A6) interaction partners

  1. Results reveal the role of electrical activity in the process of neuromuscular junction (NMJ) denervation and subsequent neurodegeneration in Andermann syndrome. Study found that loss of KCC3 function is associated with an abnormal intrinsic neuronal electrical activity. Notably, we show that pharmacologically decreasing the firing frequency of Slc12a6-/- motoneurons partially rescues innervation at the NMJ.

  2. electrophysiological studies using the threshold tracking technique indicated a reduced stimulus-response curve slope with an elevated rheobase, a decreased strength-duration time constant, diminished persistent Na(+) currents, and an outward deviation of threshold electrotonus in KCC3(-/-) nerves compared to wild-type nerves

  3. These results suggest that the function of the peripheral nervous system depends on finely tuned, kinase-regulated KCC3 activity and implicate abnormal cell volume homeostasis as a previously unreported mechanism of axonal degeneration.

  4. Kcc3 inactivation caused systemic vascular resistance and ventricular mass to increase while preventing extracellular fluid volume to accumulate.

  5. The results establish that the parvalbumin (show PVALB Antibodies)-positive neuronal population is an important player in the pathogenic development of peripheral neuropathy associated with agenesis of the corpus callosum.

  6. Data are consistent with a role for KCC3 in the proximal tubule glucose reabsorption mechanism.

  7. KCC3 regulates NADPH oxidase (show NOX1 Antibodies) activity and neutrophils activation

  8. KCC3 contributes to Cl(-) extrusion in adult sensory neurons

  9. K+-Cl-cotransporter (show SLC12A4 Antibodies) KCC3 is expressed in neurons, interneurons and radial glial-like cells in the spinal cord.

  10. KCC3 is the dominant isoform in erythrocytes, with variable expression of KCC1 (show SLC12A4 Antibodies) and KCC4 (show SLC12A7 Antibodies) that could result in modulation of KCC activity

Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 6 (SLC12A6) Antigen Profile

Protein Summary

This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy.

Gene names and symbols associated with SLC12A6

  • solute carrier family 12, member 6 (Slc12a6) antibody
  • solute carrier family 12 member 6 (SLC12A6) antibody
  • 9530023I19Rik antibody
  • ACCPN antibody
  • gaxp antibody
  • KCC3 antibody
  • KCC3A antibody
  • KCC3B antibody

Protein level used designations for SLC12A6

solute carrier family 12 member 6 , furosemide-sensitive KCl cotransporter 3 , K-Cl cotransporter 3 , electroneutral potassium-chloride cotransporter 3 , potassium chloride cotransporter 3 , potassium chloride cotransporter KCC3a-S3 , potassium-chloride transporter-3a , potassium-chloride transporter-3b , solute carrier family 12 (potassium/chloride transporters), member 6

GENE ID SPECIES
691209 Rattus norvegicus
9990 Homo sapiens
107723 Mus musculus
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