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Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. Additionally we are shipping Solute Carrier Family 22 (Organic Cation Transporter), Member 2 Antibodies (72) and Solute Carrier Family 22 (Organic Cation Transporter), Member 2 Proteins (6) and many more products for this protein.
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OCT2-altered expression in primary and metastatic cancer cells.
Circ2174 has sequence complementarity to miR149 which can target Oct-2.These data suggest a mechanism whereby circ2174 can act as a sponge to regulate the expression of miR149, and thereby modulate Oct-2 and interleukin-16 (show IL16 ELISA Kits) signaling pathways in cholangiocarcinoma.
SLC22A2 deletion is associated with motor speech disorders, and language delays.
inhibitory potency for morphine uptake was affected by the OCT1 (show POU2F1 ELISA Kits)*2 allele. OCT2 showed only a limited uptake of ranitidine that was not significantly affected by the Ala270Ser polymorphism
Pazopanib inhibits OCT2, MATE1 and MATE2-K, which are involved in cisplatin secretion into urine, potentiating cisplatin toxicity.
The combination of ENT1, MATE1 and OCT2 SNPs may serve as a predictive and prognostic marker in metastatic colorectal carcinoma patients treated with TAS-102.
This study of SLC22A2 contributes in filling the gap that exists with regards to genetic information about important variations in organic cation transporter genes for the indigenous populations of South Africa.
we assessed the role of miR (show MLXIP ELISA Kits)-21 in mediating renal cell carcinoma (show MOK ELISA Kits) chemoresistance and further showed that miR (show MLXIP ELISA Kits)-21 silencing significantly (1) increased chemosensitivity of paclitaxel, 5-fluorouracil, oxaliplatin, and dovitinib; (2) decreased expression of multi-drug resistance genes; and (4) increased SLC22A1/OCT1, SLC22A2/OCT2, and SLC31A1/CTR1 (show SLC31A1 ELISA Kits) platinum influx transporter expression
Oct2 and Bob1 are very reliable in determining B cell lineage in the absence of expression of other pan-B cell markers
Formononetin prevents cisplatin-induced acute kidney injury by targeting Oct2/TP53 (show TP53 ELISA Kits) in the kidney.
Findings identify OCT2 as a genetic factor that directly impacts on the molecular and hormonal events taking place during acute stress, accentuating the noxious effects of repeated stress on the development of stress-related phenotypes
Molecular components of the circadian clock regulated the renal expression of Slc22a2, which resulted in rhythmic oscillations in OCT2 protein levels.
Cellular uptake of oxaliplatin increases by 16- to 35-fold in cells overexpressing Oct2, a process associated with increased DNA platination and oxaliplatin-induced cytotoxicity.
Data indicate that the expression of the organic cation transporters Slc22a1 (show SLC22A1 ELISA Kits), Slc22a2 and Slc22a3 (show OCT3 ELISA Kits) essential for the cellular uptake of metformin was highly suppressed in Tsc1 (show TSC1 ELISA Kits)+/-renal tumours.
findings identify OCT2 as an important postsynaptic determinant of aminergic tonus and mood-related behaviors.
Slc22a2 is one of three imprinted genes on chromosome 17 that is expressed from the maternal allele. A non-coding Air RNA is required for repression of all three genes on the paternal allele.
OCT1 (show POU2F1 ELISA Kits) and OCT2 are important for N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP (show PTPN2 ELISA Kits)) transfer across the blood-brain barrier and amantadine reduces the blood-brain barrier transfer of MPTP (show PTPN2 ELISA Kits) and MPTP (show PTPN2 ELISA Kits)-induced dopaminergic toxicity in rodents.
a comparison of the transport properties of Oct2 and Oct1 (show POU2F1 ELISA Kits)
This study shows that Oct1 (show POU2F1 ELISA Kits) and Oct2 together are essential for renal secretion of (small) organic cations.
The carboxy-terminal activation domain of Oct-2 is required to mediate the unique and indispensable functions of the Oct-2 transcription factor in vivo.
OCTN2 expression and carnitine transport in cattle, as in rodents, are regulated by PPARalpha (show PPARA ELISA Kits).
Gene expression of the carnitine transporter OCTN2 and carnitine transport are regulated by PPARbeta (show PPARD ELISA Kits)/delta in bovine cells.
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption.
organic cation transporter 2
, solute carrier family 22 member 2
, solute carrier family 22, member 2
, apical organic cation transporter
, Organic cation transporter 2
, solute carrier family 22 (organic cation transporter), member 2
, solute carrier family 22 (organic cation transporter), member 2 L homeolog