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Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. Additionally we are shipping Solute Carrier Family 22 (Organic Cation Transporter), Member 2 Antibodies (86) and Solute Carrier Family 22 (Organic Cation Transporter), Member 2 Kits (1) and many more products for this protein.
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inhibitory potency for morphine uptake was affected by the OCT1 (show POU2F1 Proteins)*2 allele. OCT2 showed only a limited uptake of ranitidine that was not significantly affected by the Ala270Ser polymorphism
Pazopanib inhibits OCT2, MATE1 and MATE2-K, which are involved in cisplatin secretion into urine, potentiating cisplatin toxicity.
The combination of ENT1 (show SLC29A1 Proteins), MATE1 and OCT2 SNPs may serve as a predictive and prognostic marker in metastatic colorectal carcinoma patients treated with TAS (show MAP3K4 Proteins)-102.
This study of SLC22A2 contributes in filling the gap that exists with regards to genetic information about important variations in organic cation transporter genes for the indigenous populations of South Africa.
we assessed the role of miR (show MLXIP Proteins)-21 in mediating renal cell carcinoma (show MOK Proteins) chemoresistance and further showed that miR (show MLXIP Proteins)-21 silencing significantly (1) increased chemosensitivity of paclitaxel, 5-fluorouracil, oxaliplatin, and dovitinib; (2) decreased expression of multi-drug resistance genes; and (4) increased SLC22A1/OCT1, SLC22A2/OCT2, and SLC31A1/CTR1 (show SLC31A1 Proteins) platinum influx transporter expression
Oct2 and Bob1 are very reliable in determining B cell lineage in the absence of expression of other pan-B cell markers
Formononetin prevents cisplatin-induced acute kidney injury by targeting Oct2/TP53 (show TP53 Proteins) in the kidney.
OCT2 polymorphisms were associated with hematological toxicity in non-small cell lung cancer patients.
An association was found between SNPs in OCT2 transporter and lack of metformin response in type 2 diabetes mellitus patients.
Seventeen of the variants observed in the SLC22A2 gene of the Xhosa population were specific to/or occurred at a higher frequency in African populations or populations with a recent connection to the African continent.
OCTN2 (show SLC22A5 Proteins) expression and carnitine transport in cattle, as in rodents, are regulated by PPARalpha (show PPARA Proteins).
Gene expression of the carnitine transporter OCTN2 (show SLC22A5 Proteins) and carnitine transport are regulated by PPARbeta (show PPARD Proteins)/delta in bovine cells.
Findings identify OCT2 as a genetic factor that directly impacts on the molecular and hormonal events taking place during acute stress, accentuating the noxious effects of repeated stress on the development of stress-related phenotypes
Molecular components of the circadian clock regulated the renal expression of Slc22a2, which resulted in rhythmic oscillations in OCT2 protein levels.
Cellular uptake of oxaliplatin increases by 16- to 35-fold in cells overexpressing Oct2, a process associated with increased DNA platination and oxaliplatin-induced cytotoxicity.
Data indicate that the expression of the organic cation transporters Slc22a1 (show SLC22A1 Proteins), Slc22a2 and Slc22a3 (show OCT3 Proteins) essential for the cellular uptake of metformin was highly suppressed in Tsc1 (show TSC1 Proteins)+/-renal tumours.
findings identify OCT2 as an important postsynaptic determinant of aminergic tonus and mood-related behaviors.
Slc22a2 is one of three imprinted genes on chromosome 17 that is expressed from the maternal allele. A non-coding Air RNA is required for repression of all three genes on the paternal allele.
OCT1 (show POU2F1 Proteins) and OCT2 are important for N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP (show PTPN2 Proteins)) transfer across the blood-brain barrier and amantadine reduces the blood-brain barrier transfer of MPTP (show PTPN2 Proteins) and MPTP (show PTPN2 Proteins)-induced dopaminergic toxicity in rodents.
a comparison of the transport properties of Oct2 and Oct1 (show POU2F1 Proteins)
This study shows that Oct1 (show POU2F1 Proteins) and Oct2 together are essential for renal secretion of (small) organic cations.
The carboxy-terminal activation domain of Oct-2 is required to mediate the unique and indispensable functions of the Oct-2 transcription factor in vivo.
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption.
, POU domain, class 2, transcription factor 2
, lymphoid-restricted immunoglobulin octamer-binding protein NF-A2
, octamer-binding protein 2
, octamer-binding transcription factor 2
, organic cation transporter 2
, solute carrier family 22 member 2
, apical organic cation transporter
, solute carrier family 22, member 2