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Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. Additionally we are shipping SLC22A4 Antibodies (37) and SLC22A4 Kits (1) and many more products for this protein.
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OCTN1 negatively regulated the induction of inflammatory cytokine IL-1beta (show IL1B Proteins)
Dysfunction of intestinal OCTN1 in mouse model of chronic kidney disease (CKD) impaired the OCTN1-ergothioneine axis, an adaptive antioxidant system, and that decreased antioxidant ergothioneine levels may contribute to CKD progression in a PDZK1 (show PDZK1 Proteins)-dependent manner.
OCTN1 is functionally expressed on activated intestinal macrophages, and ergothioneine uptake into these immune cells could contribute at least in part to the altered disposition of ergothioneine in intestinal inflammation.
The bile acids that accumulated in intestinal epithelial cells suppressed PPARalpha (show PPARA Proteins)-mediated transactivation of Octn1 in the dark phase.
OCTN1 is involved in cellular differentiation, but inhibits their proliferation, possibly via the regulation of cellular oxidative stress
These results indicate that OCTN1 plays a pivotal role for maintenance of systemic and intestinal exposure of ergothioneine
antibody raised to an epitope during C. jejuni or M. paratuberculosis enterocolitis may crossreact with an intestinal epithelial cell functional variant of OCTN1, an already less efficient carnitine transporter, initiating inflammatory bowel disease
OCTN1 mitochondrial localization was confirmed by Transmission Electron Microscopy of heart.
Octn1 is expressed throughout the CNS with a pattern suggestive of roles in cerebral bioenergetics and in acetylcholine generation for neurotransmission in olfactory, satiety, limbic, memory, motor and sensory functions.
Octn1, -2, and -3 are expressed in many regions of murine heart
The expression of SLC22A4, IL1R2 (show IL1R2 Proteins) and VNN3 (show VNN3 Proteins), were independently associated with elevated neutrophil-to-lymphocyte ratio in chronic heart failure patients.
Functional expression of Octn1 was demonstrated in activated hepatic stellate cell lines.
Studies confirmed OCTN1-mediated transport of cytarabine and various structurally related cytidine analogues, such as 2'deoxycytidine and gemcitabine, occurs through a saturable process that is highly sensitive to inhibition by the classic nucleoside transporter inhibitors.
These data reveal a role of OCTN1 in transporting acetylcholine and choline in HeLa cells.
mutation in SLC22A4 encoding an organic cation transporter expressed in the cochlea strial endothelium causes human recessive non-syndromic hearing loss.
SLC22A4 was associated with joint erosion in not-very-longstanding RA, although RA susceptibility association was weak and its clinical significance was uncertain.
Functional expression of OCTN1 was confirmed in LPS-stimulated human macrophage-like cell line, THP-1.
This meta-analysis demonstrates that the SLC22A4 F1 polymorphism is associated with susceptibility to RA in East Asians, but not in Europeans.
Report functional/molecular effects of mercury compounds on the human OCTN1 cation transporter: C50 and C136 are the targets for potent inhibition.
A lack of association between the SLC22A4 gene polymorphism rs3792876 and susceptibility to autoimmune thyroid diseases in a Chinese Han population.
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent.
solute carrier family 22 member 4
, solute carrier family 22 member 5
, solute carrier family 22 (organic cation/ergothioneine transporter), member 4
, solute carrier family 22 (organic cation transporter), member 4
, Solute carrier family 22 member 4
, LSTP-Like 2
, organic cation transporter 1
, organic cation/carnitine transporter 1
, solute carrier family (organic cation transporter), member 4
, solute carrier family 22, member 4
, ET transporter
, ergothioneine transporter
, integral membrane transport protein
, organic cation transporter OCTN1