Solute Carrier Family 22 Member 5 Proteins (SLC22A5)

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. Additionally we are shipping SLC22A5 Antibodies (36) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC22A5 6584 O76082
SLC22A5 20520 Q9Z0E8
Rat SLC22A5 SLC22A5 29726 O70594
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Top SLC22A5 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$5,262.31
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$7,493.38
Details
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$230.67
Details

SLC22A5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
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More Proteins for Solute Carrier Family 22 Member 5 (SLC22A5) Interaction Partners

Human Solute Carrier Family 22 Member 5 (SLC22A5) interaction partners

  1. Study observed no influence of 5-HTTLPR polymorphisms on post- sleep recognition performance for positive, neutral or negative images.

  2. Study shows that low carnitine levels seem to be associated with Parkinson's disease, but only in individuals without the c.95A>G mutation in the SLC22A5 gene rendering the carnitine transporter less efficient. Thus, the difference in carnitine levels is not caused by a higher frequency of c.95A>G mutation carriers in cases.

  3. Single nucleotide polymorphism in SLC22A5 gene is associated with colorectal cancer.

  4. When endogenous OCTN2-mediated colistin transport was inhibited by co-incubation with L-carnitine, primary mouse proximal tubular cells were fully protected from colistin toxicity

  5. The OCTN2 carnitine transporter is essential for retaining carnitine in the body and allowing adequate supplies to the heart and the skeletal muscle, which derive most of their energy from fat. Mutations impairing its function result in carnitine deficiency that can present early in life with hypoketotic hypoglycemia, or later in life with cardiomyopathy and sudden death from cardiac arrhythmia. Review.

  6. A homozygous stop variant in the SLC22A5 gene in a family with cardiomyopathy and sudden death history.

  7. Elucidation of GM-CSF signaling demonstrates that the cytokine causes the activation of mTOR kinase, leading to the phosphorylation and activation of STAT3, which, in turn, is responsible for OCTN2 transcription.

  8. dissociation of bound substrate from the transporter is rate limiting in establishing maximal rates of OCT2-mediated transport

  9. It is postulated that ZO-1, when not phosphorylated by PKC, keeps Octn2 in an active state, while elimination of this binding in DeltaPDZ mutant or after ZO-1 phosphorylation leads to diminution of Octn2 activity.

  10. Results confirmed the diagnosis of eight patients with systemic primary carnitine deficiency (CDSP) on the gene level, including six mutations found in the solute carrier family 22 member 5 (SLC22A5) gene.

  11. Our results suggest that a common promoter haplotype of OCTN2 regulates the transcriptional rate of OCTN2 and influences the clinical course of CD.

  12. The local genotype influences methylation levels at SLC22A5 and ZPBP2 promoters independently of the asthma status. Further studies are necessary to confirm the relationship between GSDMA-ZPBP2 and SLC22A5 methylation and asthma in females and males separately.

  13. The results of the current study demonstrated that -207C>G polymorphism of the SLC22A5 gene is not associated with male infertility.

  14. Functional activity of L-carnitine transporters in human airway epithelial cells.

  15. c.760C>T (p.R254X) mutation of the SLC22A5 gene is associated with the primary carnitine deficiency.

  16. Human OCTN2 expression is directly regulated by PPAR-alpha.

  17. Nine novel SLC22A5 gene mutations were identified and characterized in Chinese patients with Systemic primary carnitine deficiency CDSP. The R254X mutation was the most frequent, and it could likely be an ethnic founder mutation.

  18. A novel in-frame deletion (p.F23del), and a novel nonsense mutation (p.Q180X) result in primary carnitine deficiency.

  19. Mutation analysis of the gene SLC22A5 confirms the diagnosis of primary systemic carnitine deficiency.

  20. OCTN2 is involved in L-carnitine transport at the human BBB.

Mouse (Murine) Solute Carrier Family 22 Member 5 (SLC22A5) interaction partners

  1. Both mRNA and protein levels of OCTN2 were detected in kidney after exercise and during recovery, suggesting renal transport mechanisms were stimulated. These changes were accompanied with a reciprocal increase in PPARalpha protein expression.

  2. There was increased apoptosis in gut samples from OCTN2(-/-) mice.

  3. Colon OCTN2 gene expression is up-regulated by peroxisome proliferator-activated receptor gamma in humans and mice and contributes to local and systemic carnitine homeostasis.

  4. OCTN2, a transporter that is thought to be responsible for the accumulation of L-carnitine in the epididymal lumen, is regulated in response to changes in tonicity.

  5. Mouse OCTN2 is a direct target gene of PPARalpha and transcriptional upregulation of OCTN2 by PPARalpha is likely mediated via PPRE1 in its first intron.

  6. acetyl-L-carnitine is transported from blood to brain extracellular fluid by OCTN2

  7. placental OCTN2 is obligatory for accumulation of carnitine in placenta & fetus, fatty acid beta-oxidation enzymes are expressed in placenta & reduced carnitine levels upregulate expression of short-chain L-3-hydroxyacyl CoA dehydrogenase in placenta

  8. Novel OCTN2 in mouse pancreas.

  9. OCTN2 functions as a carnitine transporter between the epithelium and the lumen in distal corpus and cauda epididymides and provides a clue as to why obstructive azoospermia is induced in distal parts of epididymis.

  10. These findings indicate that OCTN2 is predominantly responsible for the uptake of carnitine from the apical surface of mouse small intestinal epithelial cells.

  11. This distribution may play a role in the pattern of neurological injury that occurs in hOCTN2 deficiency during catabolic episodes of hypoglycemic, hypoketotic encephalopathy and which may manifest with cognitive impairment, hypotonia and seizures.

  12. PPAR alpha-activation results in enhanced carnitine biosynthesis and OCTN2-mediated hepatic carnitine accumulation

  13. PPARalpha up-regulates the expression of Slc22a5 in small intestine.

  14. shows that transcriptional upregulation of OCTN2 and OCTN3 in tissues and of enzymes involved in hepatic carnitine biosynthesis are mediated by PPAR alpha

  15. PDZK1 regulates two intestinal transporters, Slc15a1 and Slc22a5, as an adaptor protein for these transporters and affects oral absorption of their substrates.

  16. OCTN2 is functionally expressed on the plasma membrane of muscle cells and is involved in distribution of carnitine to the heart.

  17. Octn1, -2, and -3 are expressed in many regions of murine heart

Cow (Bovine) Solute Carrier Family 22 Member 5 (SLC22A5) interaction partners

  1. Dopamine transport across the olfactory and respiratory mucosae is partially mediated by organic cation transporters, including OCT-1 and OCT-2. OCT-2 was localized in the epithelial and submucosal regions of the nasal olfactory and respiratory mucosa

SLC22A5 Protein Profile

Protein Summary

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is a plasma integral membrane protein which functions both as an organic cation transporter and as a sodium-dependent high affinity carnitine transporter. The encoded protein is involved in the active cellular uptake of carnitine. Mutations in this gene are the cause of systemic primary carnitine deficiency (CDSP), an autosomal recessive disorder manifested early in life by hypoketotic hypoglycemia and acute metabolic decompensation, and later in life by skeletal myopathy or cardiomyopathy.

Gene names and symbols associated with SLC22A5

  • solute carrier family 22 member 5 (SLC22A5)
  • solute carrier family 22 (organic cation transporter), member 5 (Slc22a5)
  • solute carrier family 22 member 5 (LOC100358417)
  • solute carrier family 22 member 5 L homeolog (slc22a5.L)
  • solute carrier family 22 member 5 (Slc22a5)
  • organic cation/carnitine transporter 2 (OCT2)
  • ATOCT2 protein
  • CDSP protein
  • CT1 protein
  • jvs protein
  • Lstpl protein
  • MGC68932 protein
  • OCT2 protein
  • Octn2 protein
  • OCTN2VT protein
  • organic cation/carnitine transporter 2 protein
  • ORGANIC CATION TRANSPORTER 2 protein
  • slc22a5 protein
  • UST2r protein
  • YUP8H12R.2 protein
  • YUP8H12R_2 protein

Protein level used designations for SLC22A5

high-affinity sodium dependent carnitine cotransporter , organic cation/carnitine transporter 2 , solute carrier family 22 member 5 , high-affinity sodium-dependent carnitine cotransporter , juvenile visceral steatosis , solute carrier family 22 (organic cation/carnitine transporter), member 5 , solute carrier family 22 (organic cation transporter), member 5 , solute carrier family 22, member 5 , high-affinity carnitine transporter , integral membrane transport protein

GENE ID SPECIES
6584 Homo sapiens
20520 Mus musculus
416328 Gallus gallus
541266 Bos taurus
100137218 Papio anubis
100358417 Oryctolagus cuniculus
380592 Xenopus laevis
29726 Rattus norvegicus
608146 Canis lupus familiaris
100072871 Equus caballus
100520422 Sus scrofa
844274 Arabidopsis thaliana
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