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SLC25A5 is a member of the mitochondrial carrier subfamily of solute carrier protein genes. Additionally we are shipping SLC25A5 Kits (12) and SLC25A5 Proteins (7) and many more products for this protein.
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Deficiency in the mouse mitochondrial ANT2 gene is associated with cardiac noncompaction.
IFNgamma induces oxidative stress, DNA damage and tumor cell senescence via TGFbeta/SMAD signaling-dependent induction of Nox4 and suppression of ANT2
Erythroid and B-cell development may be particularly vulnerable to Ant2 depletion-mediated mitochondrial dysfunction and oxidative stress.
Sirt4 (show SIRT4 Antibodies) regulates ATP levels via ANT2 and a feedback loop involving AMPK (show PRKAA1 Antibodies).
The mammalian proteins MMS19, MIP18, and ANT2 are involved in cytoplasmic iron-sulfur cluster protein assembly.
ANT2 and ANT1 (show SLC25A4 Antibodies) regulate L1-mediated neurite outgrowth in conjunction with MMP14 (show MMP14 Antibodies) at the plasma membrane.
In liver only Ant2 mRNA was found, but in brown adipose tissue, Ant1 & Ant2 mRNA levels were equal. The ANT2 isoform may mediate fatty-acid-induced uncoupling.
At high protonmotive force, an endogenously generated activator stimulates proton conductance catalysed partly by UCP3 (show UCP3 Antibodies) and partly by the adenine nucleotide translocase.
Findings suggest that ANT2 overexpression contributes to EGFR (show EGFR Antibodies)-TKI resistance in non-small cell lung cancer.
Study found that ANT2 was upregulated in sorafenibresistant hepatocellular carcinoma Huh7 cell line and its overexpression promoted sorafenib resistance.
ANT2 shRNA downregulates miR (show MLXIP Antibodies)-19a and miR (show MLXIP Antibodies)-96 through the PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) pathway and suppresses tumor growth in hepatocellular carcinoma cells.
TGF-beta (show TGFB1 Antibodies)-mediated suppression of ANT2 through NF1 (show NF1 Antibodies)/Smad4 (show SMAD4 Antibodies) complexes contributes to oxidative stress and DNA damage during induction of cellular senescence.
ANT2 suppression by shRNA may be able to exert anticancer effects in HCC (show FAM126A Antibodies) further by restoring SOCS1 (show SOCS1 Antibodies) expression
SLC25A5 is involved in memory formation or establishment, which could add mitochondrial processes to the wide array of pathways that regulate normal cognitive functions.
miR (show MLXIP Antibodies)-636 might function as a tumor suppressor miRNA affecting hepatocellular carcinoma (HCC (show FAM126A Antibodies)) tumorigenesis via downregulation of Ras, and that ANT2 suppression by shRNA could exert an anticancer effect by restoring miR (show MLXIP Antibodies)-636 expression in HCC (show FAM126A Antibodies).
Apigenin upregulates DR5 and enhances TRAIL induced apoptosis by binding and inhibiting ANT2.
This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this gene.
adenine nucleotide translocator 2
, ADP,ATP carrier protein 2
, ADP/ATP translocase 2
, ANT 2
, adenine nucleotide translocase
, adenine nucleotide translocator 2, fibroblast
, solute carrier family 25 member 5
, ADP,ATP carrier protein, fibroblast isoform
, ADP/ATP carrier protein
, adenine nucleotide translocator 2 (fibroblast)
, Adenine nucleotid translocator 2 fibroblast isoform (ATP-ADP carrier protein)
, Adenine nucleotid translocator 2, fibroblast isoform (ATP-ADP carrier protein)
, adenine nucleotide translocator 2 fibroblast isoform (ATP-ADP carrier protein)
, adenine nucleotide translocator 2, fibroblast isoform (ATP-ADP carrier protein)