Solute Carrier Family 25 (Mitochondrial Carrier, Ornithine Transporter) Member 15 Proteins (SLC25A15)

SLC25A15 is a member of the mitochondrial carrier family. Additionally we are shipping SLC25A15 Antibodies (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat SLC25A15 SLC25A15 306574  
SLC25A15 18408 Q9WVD5
SLC25A15 10166 Q9Y619
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Top SLC25A15 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$4,649.05
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$6,616.87
Details
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$338.33
Details

SLC25A15 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Solute Carrier Family 25 (Mitochondrial Carrier, Ornithine Transporter) Member 15 (SLC25A15) Interaction Partners

Mouse (Murine) Solute Carrier Family 25 (Mitochondrial Carrier, Ornithine Transporter) Member 15 (SLC25A15) interaction partners

Human Solute Carrier Family 25 (Mitochondrial Carrier, Ornithine Transporter) Member 15 (SLC25A15) interaction partners

  1. Compares and contrasts all the known human SLC25A (show SLC25A25 Proteins)* genes and includes functional information.

  2. characterized mutations of the proposed substrate binding site in ORC1 and ORC2; demonstrated that the residue at position 179 in the 2 soforms is largely responsible for the difference in their substrate specificity;concluded that Arg-179 is a key residue in the opening of the carrier to the matrix side

  3. Mutation analysis revealed two novel mutations in the ORNT1 gene.

  4. Useful insights for in-depth understanding of the molecular mechanism of the HHH syndrome and developing effective drugs against the disease.

  5. Hyperornithinemia, hyperammonemia, and homocitrullinuria syndrome with evidence of mitochondrial dysfunction due to a novel SLC25A15 (ORNT1) gene mutation in a Palestinian family.

  6. A novel R275X mutation of the SLC25A15 gene in a Japanese patient with the HHH syndrome

  7. The three patients were homozygous for a novel mutation in ORNT1 with a Gly220Arg change. We suggest including HHH syndrome in the differential diagnosis of patients found to have stroke-like lesions on brain MRI (show C7ORF49 Proteins).

  8. Clinical presentations and outcomes varied significantly in HHH syndrome patients homozygous for delF188 mutations in SLC25A15.

  9. 16 additional Hyperornithinemia-hyperammonemia-homocitrullinuria cases were collected and the spectrum of SLC25A15/ORC1 mutations, was expanded.

SLC25A15 Protein Profile

Protein Summary

This gene is a member of the mitochondrial carrier family. The encoded protein transports ornithine across the inner mitochondrial membrane from the cytosol to the mitochondrial matrix. The protein is an essential component of the urea cycle, and functions in ammonium detoxification and biosynthesis of the amino acid arginine. Mutations in this gene result in hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome. There is a pseudogene of this locus on the Y chromosome.

Gene names and symbols associated with SLC25A15

  • solute carrier family 25 member 15 (Slc25a15)
  • solute carrier family 25 (mitochondrial carrier ornithine transporter), member 15 (Slc25a15)
  • solute carrier family 25 member 15 (SLC25A15)
  • Ab1-114 protein
  • D13S327 protein
  • D630044L02Rik protein
  • HHH protein
  • ORC1 protein
  • ORNT1 protein

Protein level used designations for SLC25A15

mitochondrial ornithine transporter 1 , ornithine transporter) member 15 , ornithine transporter, mitochondrial 1 , solute carrier family 25 member 15 , ornithine transporter 1

GENE ID SPECIES
306574 Rattus norvegicus
18408 Mus musculus
10166 Homo sapiens
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