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SLC34A3 encodes a member of SLC34A transporter family of proteins, and is expressed primarily in the kidney. Additionally we are shipping SLC34A3 Proteins (5) and many more products for this protein.
Showing 10 out of 25 products:
Dog (Canine) Polyclonal SLC34A3 Primary Antibody for WB - ABIN2779489
Yamamoto, Michigami, Aranami, Segawa, Yoh, Nakajima, Miyamoto, Ozono: Hereditary hypophosphatemic rickets with hypercalciuria: a study for the phosphate transporter gene type IIc and osteoblastic function. in Journal of bone and mineral metabolism 2007
Show all 2 Pubmed References
we have generated a renal-specific and inducible knockout model of NaPi-IIc/Slc34a3. absence of NaPi-IIc does not disturb the homeostasis of Pi in mice. However, ablation of the cotransporter in weaning mice does not alter the homeostasis of Ca2 (show CA2 Antibodies)+.
The expression of Npt2c-v1 mRNA was detected in the heart, spleen, testis, uterus, placenta, femur, cerebellum, hippocampus, diencephalon and brain stem and sperm of mouse.
reduced intestinal Pi absorption in VDR (-/-) mice does not seem to be the only factor that causes hypophosphatemia; reduced Npt2a, Npt2c, or PiT-2 protein levels during development might also cause hypophosphatemia and rickets in VDR (-/-) mice.
Targeting of NaPi-IIc to the apical surface of renal epithelial cells is regulated by a unique amino acid motif in the cytoplasmic C-terminal domain.
Findings suggest that Npt2a, Npt2c, and PiT-2 (show SLC20A2 Antibodies) are necessary for the phosphaturic activity of FGF23 (show FGF23 Antibodies).
NaPi-IIc mRNA and protein was up-regulated by the low-Pi diet in all nephron generations analysed
Npt2c maintains normal Ca metabolism, in part by modulating the vitamin D/fibroblast growth factor 23 (show FGF23 Antibodies) axis.
Differential regulation of the renal sodium-phosphate cotransporters NaPi-IIa, NaPi-IIc, and PiT-2 (show SLC20A2 Antibodies) in dietary potassium deficiency.
FGF23 (show FGF23 Antibodies) decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1.
Npt2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development.
genetic characteristics of 15 families with hereditary hypophosphatemia: Novel Mutations in PHEX (show PHEX Antibodies) and SLC34A3
This is the report of a patient with compound heterozygous mutations of SLC34A3 and normal skeletal features. Biallelic mutations in SLC34A3 can thus be associated with hypercalciuria not accompanied by rickets.
Individuals with mutations affecting both SLC34A3 alleles had a significantly increased risk of kidney stone formation or medullary nephrocalcinosis, namely 46% compared with 6% observed in healthy family members carrying only the wild-type allele.
this study reports the first cases of hereditary hypophosphatemic rickets with hypercalciuria in Africa and describes a novel causal mutation within the SLC34A3 gene
A man with hereditary hypophosphataemic rickets with hypercalciuria & his 3 heterozygous children had a mutation in intron 5 of gene SLC34A3 (NM_080877.2:c[ 448 +5G>A] + [ 448 +5G>A]).
Data show 101-bp deletion in intron 9 of the SLC34A3 gene.
SLC34A3 mutations (exons and introns) were searched in two previously not reported hereditary hypophosphatemic rickets with hypercalciuria kindreds, which resulted in the identification of three novel mutations.
these data suggest that mutations in SLC34A3 in hereditary hypophosphatemic rickets with hypercalciuria result in defective processing and stability
Functionally important sites in the predicted first and fourth extracellular linkers of the type IIa Na+/Pi cotransporter (NaPi-IIa) were identified by cysteine scanning mutagenesis (Ehnes et al., 2004).
NaP(i)-IIc has a key role in the regulation of phosphate homeostasis.
This gene encodes a member of SLC34A transporter family of proteins, and is expressed primarily in the kidney. It is involved in transporting phosphate into cells via sodium cotransport in the renal brush border membrane, and contributes to the maintenance of inorganic phosphate concentration in the kidney. Mutations in this gene are associated with hereditary hypophosphatemic rickets with hypercalciuria. Alternatively spliced transcript variants varying in the 5' UTR have been found for this gene.
solute carrier family 34 (sodium phosphate), member 3
, sodium-dependent phosphate cotransporter isoform NaPi-IIc
, Na(+)-dependent phosphate cotransporter 2C
, Na(+)/Pi cotransporter 2C
, sodium-dependent phosphate transport protein 2C
, sodium-phosphate cotransporter IIC
, sodium/phosphate cotransporter 2C
, type IIc Na+/Pi-cotransporter
, sodium-phosphate transport protein 2C
, sodium/inorganic phosphate cotransporter IIC
, type IIc Na+/Pi cotransporter
, Na+/Pi-cotransporter type IIc
, solute carrier family 34 member 3