Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) Proteins

The protein encoded by SLC4A1 is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane, where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs.

Data Quality
  • 8
Type
  • 10
    Protein
Target
  • 10
    Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) (SLC4A1)
  • 603
  • 241
  • 237
  • 212
Application
  • 8
  • 8
  • 7
  • 4
  • 3
Reactivity
  • 7
  • 2
  • 1
Host
  • 5
  • 2
  • 2
  • 1
Binding Specificity
  • 1
  • 1
  • 1
  • 1
  • 1
Conjugate
  • 2
  • 3
  • 2
  • 1
  • 1
Protein Type
  • 10
Format
  • 6
  • 1
Suggested next Filters
10 Products
Recombinant Protein, Escherichia coli (E. coli) (Source), Purity >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivityHuman
Application Crys, ELISA, SDS, WB
Order details Cat. No. ABIN3089819
$5,227.64
Plus shipping costs $45.00 and $22.00 dry ice
Delivery in 30 to 35 Business Days
Recombinant Protein, Escherichia coli (E. coli) (Source), Purity >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivityMouse
Application Crys, ELISA, SDS, WB
Order details Cat. No. ABIN3132501
$5,227.64
Plus shipping costs $45.00 and $22.00 dry ice
Delivery in 30 to 35 Business Days
Recombinant Protein, Insect Cells (Source), Purity >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivityMouse
Application Crys, ELISA, SDS, WB
Order details Cat. No. ABIN3132502
$7,307.36
Plus shipping costs $45.00 and $22.00 dry ice
Delivery in 60 to 65 Business Days
Recombinant Protein, Insect Cells (Source), Purity >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivityHuman
Application Crys, ELISA, SDS, WB
Order details Cat. No. ABIN3089818
$10,415.49
Plus shipping costs $45.00 and $22.00 dry ice
Delivery in 60 to 65 Business Days
ReactivityHuman
Application AP, AA, ELISA, WB
Order details Cat. No. ABIN1320468
$414.29
Plus shipping costs $45.00 and $22.00 dry ice
Delivery in 11 to 12 Business Days
ReactivityHuman
Application ELISA, IP, SDS, WB
Order details Cat. No. ABIN3008307
$717.56
Plus shipping costs $45.00
Delivery in 11 to 18 Business Days
ReactivityHuman
Application IP, SDS, ELISA, WB
Order details Cat. No. ABIN2124021
$729.00
Plus shipping costs $45.00
Delivery in 15 to 18 Business Days
Recombinant Protein, HEK-293 Cells (Source), Purity > 80 % as determined by SDS-PAGE and Coomassie blue staining
ReactivityHuman
Application AbP, Func, PI, STD
Order details Cat. No. ABIN2713525
$932.80
20 μg
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 11 Business Days
ReactivityHuman
Application AP, Func, ScA
Order details Cat. No. ABIN1330512
ISO
$694.29
10 μg
Plus shipping costs $45.00 and $22.00 dry ice
Delivery in 11 to 12 Business Days
ReactivityRat
Application ELISA, IP, SDS, WB
Order details Cat. No. ABIN4988810
$720.00
Plus shipping costs $45.00
Delivery in 15 to 18 Business Days
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Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) (SLC4A1) Protein Profile

Protein Summary

The protein encoded by this gene is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane, where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs. The protein comprises two domains that are structurally and functionally distinct. The N-terminal 40kDa domain is located in the cytoplasm and acts as an attachment site for the red cell skeleton by binding ankyrin. The glycosylated C-terminal membrane-associated domain contains 12-14 membrane spanning segments and carries out the stilbene disulphonate-sensitive exchange transport of anions. The cytoplasmic tail at the extreme C-terminus of the membrane domain binds carbonic anhydrase II. The encoded protein associates with the red cell membrane protein glycophorin A and this association promotes the correct folding and translocation of the exchanger. This protein is predominantly dimeric but forms tetramers in the presence of ankyrin. Many mutations in this gene are known in man, and these mutations can lead to two types of disease: destabilization of red cell membrane leading to hereditary spherocytosis, and defective kidney acid secretion leading to distal renal tubular acidosis. Other mutations that do not give rise to disease result in novel blood group antigens, which form the Diego blood group system. Southeast Asian ovalocytosis (SAO, Melanesian ovalocytosis) results from the heterozygous presence of a deletion in the encoded protein and is common in areas where Plasmodium falciparum malaria is endemic. One null mutation in this gene is known, resulting in very severe anemia and nephrocalcinosis.

Gene names and symbols associated with SLC4A1

  • solute carrier family 4 member 1 (Diego blood group) (SLC4A1) antibody
  • solute carrier family 4 (anion exchanger), member 1 (Slc4a1) antibody
  • solute carrier family 4 (anion exchanger), member 1a (Diego blood group) (slc4a1a) antibody
  • Band 3 (LOC100136769) antibody
  • erythrocyte membrane protein band 4.1 like 3 (EPB41L3) antibody
  • solute carrier family 4 member 1 (Diego blood group) L homeolog (slc4a1.L) antibody
  • solute carrier family 4 member 1 (SLC4A1) antibody
  • solute carrier family 4 member 1 (Diego blood group) (slc4a1) antibody
  • solute carrier family 4 member 1 (Slc4a1) antibody
  • ae1 antibody
  • band3 antibody
  • BB3 antibody
  • bnd3 antibody
  • cd233 antibody
  • DI antibody
  • EAT antibody
  • empb3 antibody
  • epb3 antibody
  • FR antibody
  • l11Jus51 antibody
  • LOC100136769 antibody
  • MGC80391 antibody
  • MGC152771 antibody
  • rta1a antibody
  • si:dz180g5.1 antibody
  • SLC4A1 antibody
  • SW antibody
  • WD antibody
  • wd1 antibody
  • WR antibody
  • zgc:111889 antibody
  • zgc:152771 antibody

Protein level used designations for SLC4A1

Diego blood group , Froese blood group , Swann blood group , Waldner blood group , Wright blood group , anion exchange protein 1 , anion exchanger 1 , anion exchanger-1 , band 3 anion transport protein , erythrocyte membrane protein band 3 , erythroid anion exchange protein , solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) , solute carrier family 4, anion exchanger, number 1 , AE 1 , MEB3 , solute carrier family 4 member 1 , solute carrier family 4, anion exchanger, member 1 , ret , retsina , AE1/band 3 , erythroid anion exchanger 1 , Band 3 , band 4.1-like protein 3-like , solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3) , band 3 anion transport protein-like , erythroid-specific band 3 protein , erythrocyte anion transport protein , Solute carrier family 4, member 1, anion exchange protein 1 (kidney band 3)

GENE ID SPECIES
6521 Homo sapiens
20533 Mus musculus
84703 Danio rerio
100136769 Oncorhynchus mykiss
100400936 Callithrix jacchus
443978 Xenopus laevis
454727 Pan troglodytes
100009691 Equus caballus
100174401 Pongo abelii
100349024 Oryctolagus cuniculus
100483431 Ailuropoda melanoleuca
100486998 Xenopus (Silurana) tropicalis
100514249 Sus scrofa
286817 Bos taurus
396532 Gallus gallus
490939 Canis lupus familiaris
100563543 Anolis carolinensis
100579389 Nomascus leucogenys
24779 Rattus norvegicus