Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) Proteins (SLC4A1)

The protein encoded by SLC4A1 is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane, where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs. Additionally we are shipping Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) Antibodies (68) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC4A1 6521 P02730
SLC4A1 20533 P04919
SLC4A1 24779 P23562
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Top Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) Proteins at antibodies-online.com

Showing 9 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
$5,370.21
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Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
$5,370.21
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Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg 60 to 65 Days
$7,506.65
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Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg 60 to 65 Days
$10,699.55
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Escherichia coli (E. coli) Human His tag,T7 tag 100 μg 15 to 18 Days
$730.00
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Wheat germ Human GST tag 10 μg 11 to 12 Days
$414.29
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$932.80
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Wheat germ Human Un-conjugated   10 μg 11 to 12 Days
$654.29
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Escherichia coli (E. coli) Rat His tag   100 μg 15 to 18 Days
$720.00
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SLC4A1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
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Mouse (Murine) ,
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Rat (Rattus)

More Proteins for Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) (SLC4A1) Interaction Partners

Human Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) (SLC4A1) interaction partners

  1. These findings suggest that band 3 and spectrin are potential targets of autoantibodies that may be relevant for P. vivax malaria-associated anemia.

  2. The results suggest that Plasmodium falciparum glutamic acid-rich protein may play a functional role in enhancing the adhesive properties of human erythrocytes by engaging band 3 as a host receptor.

  3. A Ser725Arg mutation in Band 3 abolishes transport function and leads to anemia and renal tubular acidosis.

  4. a de novo heterozygous missense mutation previously reported (c.1765C>A, p.Arg589Ser) in the SLC4A1 gene was observed in patient IV.

  5. Large-scale simulations showed that the Glycophorin A (GPA) dimer can bridge Band 3 dimers resulting in the dynamic formation of long strands of alternating Band 3 and GPA dimers

  6. Molecular mechanism for the red blood cell senescence clock mediated by the SLC4A1 structural changes has been summarized. (Review)

  7. we show that stomatin modulates the transport activity of AE1 through a direct protein-protein interaction.

  8. SLC4A1 is the most common defective gene in Korean children with Distal Renal Tubular Acidosis. Patients with SLC4A1 mutations show later onset and milder disease severity. Long-term follow-up of hearing ability, renal function, and growth is necessary for patients with dRTA.

  9. this study shows functional importance of PDLIM5 for proper kAE1 membrane residency, as a crucial linker between kidney AE1 and actin cytoskeleton-associated proteins in polarized cells

  10. The patient was triply homozygous for the loss-of-function mutation, c.2102G>A (p.Gly701Asp) as well as for two benign variations, c.92T>C (p.Met31Thr) and c.166A>C (p.Lys56Glu).

  11. The promoter regions of the kidney anion exchanger 1 gene with the minor allele A at rs999716 downstream of the TATA box showed reduced promoter activities compared that with the major allele G.

  12. Here, we present the 4.1-A resolution crystal structure of Arabidopsis thaliana Bor1. The structure displays a dimeric architecture in which dimerization is mediated by centralized Gate domains. Comparisons with a structure of Band 3 in an outward-open state reveal that the Core domains of Bor1 have rotated inwards to achieve an occluded state.

  13. function of AQP1 in tonicity response could be coupled or correlated to its function in band 3-mediated CO2/HCO3(-) exchange

  14. Results from zero-length chemical crosslinking of erythrocyte membranes, homology modeling, and known domain structures allow to deduce a structure for full-length of SLC4A1. Interaction between AE1 dimers and ankyrin-1 indicate the likely topology for AE1 tetramers and suggest that ankyrin-1 wraps around AE1 tetramers, which may stabilize this oligomer state.

  15. The aim of this work was to analyze the prevalence of genetic defects in SLC4A1, ATP6V0A4, and ATP6V1B1 genes and to assess the clinical phenotype of distal renal tubular acidosis patients that are eventually typical of the different genetic forms of the disease.

  16. These results suggested the possible involvement of Band3 in the transport of Sphingosine 1-phosphate, a multi-functional bioactive phospholipid, from erythrocytes.

  17. the results of the present study suggest that the diffuse expression of AE1 is related to a worse prognosis in patients with advanced esophageal squamous cell carcinoma, and that it regulates tumor progression by affecting MAPK and Hedgehog signaling pathways. These results provide an insight into the role of AE1 as a mediator of and/or a biomarker for esophageal squamous cell carcinoma.

  18. study reports the R589H mutation in SLC4A1 gene in families with hereditary distal renal tubular acidosis for the first time in China

  19. Forced FOG1 protein expression in K562 erythroleukemia cells induced the expression of SLC4A1 protein, but repressed that of transcription factor PU.1.

  20. Nonsense mutation in exon 12 of SLC4A1 gene is associated with severe hemolytic anemia, dyserythropoiesis and complete distal renal tubular acidosis.

Mouse (Murine) Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) (SLC4A1) interaction partners

  1. properties are controlled by the O2-dependent association of hemoglobin with band 3

  2. NH4Cl loading elicited adaptive doubling of AE1 mRNA in GPR4+/+, but a 50% less pronounced response in GPR4-/-.

  3. Activities of AE1 and the sodium pump are coregulated in kidney.

  4. AE1 is enhanced by acidosis, NaCl, and the combination of DOCA and NaHCO3 in renal collecting ducts.

  5. These findings indicate that the conserved YXXPhi sequence or a noncanonical YXXXPhi sequence in the N-terminal region facilitates the endocytic recycling of erythroid AE1 through a clathrin-mediated pathway.

  6. These results suggest that AE1 is potentially a key therapeutic target and the silencing of AE1 expression in gastric mucosa could provide a new therapeutic approach for treating gastric cancer.

  7. These results demonstrate that mammalian erythroblast enucleation does not depend on the membrane integrity generated by the ankyrin-band 3 complex.

  8. Data suggest that glycophorin A (Gpa) increases expression and activity of Cl-/HCO3- exchanger Ae1, that G719D mutation renders Ae1 mutant constructs GPA-unresponsive, and suggests a role for Ae1 amino acids 22-28 in GPA responsiveness.

  9. podocyte protein kidney anion exchanger 1 interacts with nephrin and kinase to maintain the structure and function of the glomerular basement membrane.

  10. This review explores what is known about the erythrocyte membrane protein band 3 complexes of mice and humans, focussing on the observed species differences and their potential functional consequences.

  11. Analysis of 3 new alleles reveals previously unknown consequences of red blood cell (RBC) spectrin deficiency, resulting in markedly reduced RBC membrane spectrin content, decreased band 3, and absent beta-adducin.

  12. function as anion exchanger

  13. data increase the minimal extent of a functionally defined carbonic anhydrase 2 binding site in anion exchanger 1

  14. Hematologic and survival data from C3H, CAST/Ei F2 wan homozygotes support the hypothesis that genetic modifiers significantly influence the band-3 null hereditary spherocytosis phenotype.

  15. two regions composed of helices 6, 7 and 8 and putative helices 12 and 13 which are required for anion conductance

  16. EKLF is necessary for full transcriptional activity of the ankyrin and band 3 genes

  17. Sepsis results in elevated band-3 tyrosine phosphorylation and alters band-3 membrane organization without grossly affecting RBC anion exchange activity.

  18. The slc4a1-/- mouse is the first genetic model of complete distal renal tubular acidosis.

  19. The spectroscopic description of structural features of the P327R variant provides important clues about the location of one potential protein 4.2 binding surface on cytoplasmic domain of band 3 (cdb3) protein.

  20. Nucleotides encoding the 11-aa beta-hairpin loop in the mouse Slc4a1 gene replaced with sequence encoding a diglycine bridge thus destabilizing the eryhrocyte membrane.

Zebrafish Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) (SLC4A1) interaction partners

  1. evolutionarily conserved role for band 3 in erythroid-specific cell division and illustrates the concept of cell-specific adaptation for mitosis

Cow (Bovine) Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) (SLC4A1) interaction partners

  1. Data indicate that a synthetic polypeptide containing the N terminus of bovine AE1 bound the Sec23A-Sec24C complex through a selective interaction with Sec24C.

  2. Single particle electron microscopy analysis of the bovine anion exchanger 1 reveals a flexible linker connecting the cytoplasmic and membrane domains.

  3. These findings indicate that the conserved YXXPhi sequence or a noncanonical YXXXPhi sequence in the N-terminal region facilitates the endocytic recycling of erythroid AE1 through a clathrin-mediated pathway.

  4. findings indicate that R664X AE1 nonsense mutant is forcibly extracted from the endoplasmic reticulum to reside in aggresomes through association with deltaF508-CFTR

  5. These data demonstrate that the conserved amino acid residues Glu1, Leu2, Leu5, and Asp6 in the EL(K/Q)(L/C)LD(A/G)DD region have essential structural consequences in stable expression of AE1 at the plasma membrane.

  6. These findings indicate that AE1 R664X protein, which is associated with dominant hereditary spherocytosis, has a dominant-negative effect on the expression of wild-type AE1.

Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) (SLC4A1) Protein Profile

Protein Summary

The protein encoded by this gene is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane, where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs. The protein comprises two domains that are structurally and functionally distinct. The N-terminal 40kDa domain is located in the cytoplasm and acts as an attachment site for the red cell skeleton by binding ankyrin. The glycosylated C-terminal membrane-associated domain contains 12-14 membrane spanning segments and carries out the stilbene disulphonate-sensitive exchange transport of anions. The cytoplasmic tail at the extreme C-terminus of the membrane domain binds carbonic anhydrase II. The encoded protein associates with the red cell membrane protein glycophorin A and this association promotes the correct folding and translocation of the exchanger. This protein is predominantly dimeric but forms tetramers in the presence of ankyrin. Many mutations in this gene are known in man, and these mutations can lead to two types of disease: destabilization of red cell membrane leading to hereditary spherocytosis, and defective kidney acid secretion leading to distal renal tubular acidosis. Other mutations that do not give rise to disease result in novel blood group antigens, which form the Diego blood group system. Southeast Asian ovalocytosis (SAO, Melanesian ovalocytosis) results from the heterozygous presence of a deletion in the encoded protein and is common in areas where Plasmodium falciparum malaria is endemic. One null mutation in this gene is known, resulting in very severe anemia and nephrocalcinosis.

Gene names and symbols associated with SLC4A1

  • solute carrier family 4 member 1 (Diego blood group) (SLC4A1)
  • solute carrier family 4 (anion exchanger), member 1 (Slc4a1)
  • solute carrier family 4 (anion exchanger), member 1a (Diego blood group) (slc4a1a)
  • Band 3 (LOC100136769)
  • erythrocyte membrane protein band 4.1 like 3 (EPB41L3)
  • solute carrier family 4 member 1 (Diego blood group) L homeolog (slc4a1.L)
  • solute carrier family 4 member 1 (SLC4A1)
  • solute carrier family 4 member 1 (Diego blood group) (slc4a1)
  • solute carrier family 4 member 1 (Slc4a1)
  • ae1 protein
  • band3 protein
  • BB3 protein
  • bnd3 protein
  • cd233 protein
  • DI protein
  • EAT protein
  • empb3 protein
  • epb3 protein
  • FR protein
  • l11Jus51 protein
  • LOC100136769 protein
  • MGC80391 protein
  • MGC152771 protein
  • rta1a protein
  • si:dz180g5.1 protein
  • SLC4A1 protein
  • SW protein
  • WD protein
  • wd1 protein
  • WR protein
  • zgc:111889 protein
  • zgc:152771 protein

Protein level used designations for SLC4A1

Diego blood group , Froese blood group , Swann blood group , Waldner blood group , Wright blood group , anion exchange protein 1 , anion exchanger 1 , anion exchanger-1 , band 3 anion transport protein , erythrocyte membrane protein band 3 , erythroid anion exchange protein , solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) , solute carrier family 4, anion exchanger, number 1 , AE 1 , MEB3 , solute carrier family 4 member 1 , solute carrier family 4, anion exchanger, member 1 , ret , retsina , AE1/band 3 , erythroid anion exchanger 1 , Band 3 , band 4.1-like protein 3-like , solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3) , band 3 anion transport protein-like , erythroid-specific band 3 protein , erythrocyte anion transport protein , Solute carrier family 4, member 1, anion exchange protein 1 (kidney band 3)

GENE ID SPECIES
6521 Homo sapiens
20533 Mus musculus
84703 Danio rerio
100136769 Oncorhynchus mykiss
100400936 Callithrix jacchus
443978 Xenopus laevis
454727 Pan troglodytes
100009691 Equus caballus
100174401 Pongo abelii
100349024 Oryctolagus cuniculus
100483431 Ailuropoda melanoleuca
100486998 Xenopus (Silurana) tropicalis
100514249 Sus scrofa
286817 Bos taurus
396532 Gallus gallus
490939 Canis lupus familiaris
100563543 Anolis carolinensis
100579389 Nomascus leucogenys
24779 Rattus norvegicus
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