Solute Carrier Family 45, Member 2 Proteins (SLC45A2)

SLC45A2 encodes a transporter protein that mediates melanin synthesis. Additionally we are shipping SLC45A2 Antibodies (22) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC45A2 51151 Q9UMX9
SLC45A2 22293 P58355
Rat SLC45A2 SLC45A2 310152  
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Top SLC45A2 Proteins at

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days

SLC45A2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for Solute Carrier Family 45, Member 2 (SLC45A2) Interaction Partners

Zebrafish Solute Carrier Family 45, Member 2 (SLC45A2) interaction partners

  1. To gain understanding of the role of Slc45a2 and its possible interactions with other proteins involved in melanization, the role of the V-ATPase as a melanosomal acidifier, was analyzed.

  2. Zebrafish albino fish are mutant in slc45a2; wild-type slc45a2 mRNA rescued the albino mutant phenotype.

Human Solute Carrier Family 45, Member 2 (SLC45A2) interaction partners

  1. Study confirmed a significant role for IRF4 rs12203592 and SLC45A2 rs16891982 in the risk of cutaneous squamous cell carcinoma development in organ transplant recipients.

  2. our study demonstrates the feasibility of using tandem MS as a means of discovering shared immunogenic tumor-associated epitopes and identifies SLC45A2 as a promising immunotherapeutic target for melanoma with high tumor selectivity and reduced potential for autoimmune toxicity

  3. Evaluating the influence of haplotypes of 12 SNPs within SLC45A2 in the determination of eye, hair and skin pigmentation in a highly admixed population sample and comparing their frequencies with the ones found in data retrieved from the 1000 Genomes Project. Results emphasize the role played by haplotypes at SLC45A2 in the determination of pigmentation and reinforce the relevance of SNP L374F in human pigmentation.

  4. Data indicate AIM1 (absent in melanoma 1) as an actin binding protein and show that it regulates cytoskeletal remodeling and cell migration in prostate epithelial cells.

  5. Mutation in MATP gene expression is associated with Oculocutaneous albinism type IV.

  6. All affected members showed a novel heterozygous variant, c.208T>C (p.Y70H), in the SLC45A2 gene, which supported a diagnosis of OCA4.

  7. Our analysis revealed 10 sun-exposure-dependent gene expression quantitative trait loci (se-eQTLs), including genes involved in skin pigmentation (SLC45A2) and epidermal differentiation (RASSF9).

  8. We identitified a single missense substitution in SLC45A2 in 13 families with oculocutaneous albinism.

  9. The reduction of tyrosinase activity associated with the knockdown of MATP.

  10. The results indicated that the D93N mutation causes OCA4 as a result of loss of MATP transport activity, and that the F374 allele confers significantly lower transport activity than L374.

  11. we propose that natural selection in South Europeans is favoring the allele SLC45A2 374F.

  12. High-resolution array-CGH in patients with oculocutaneous albinism identifies new deletions of the TYR, OCA2, and SLC45A2 genes and a complex rearrangement of the OCA2 gene.

  13. Results show that almost all the African populations located below 16 degrees of latitude are fixed for the 374l allele of SLC45A2 gene.

  14. molecular defects in SLC45A2 gene represent the 3.4% of people with oculocutaneous albinism in this cohort of Italian patients, similar to other Caucasian populations

  15. We examined the association between 12 variants of four pigmentation-related genes (TYR, OCA2, SLC45A2, MC1R) and variations in the melanin index of 456 Japanese females using a multiple regression analysis.

  16. We report four Pakistani albinism mutations, including three SLC45A2 alleles and one 22-nucleotide deletion in TYRP1.

  17. A novel large deletion mutation was detected and identified in oculocutaneous albinism type IV.

  18. In South European populations, MC1R red hair color and SCL45A2 p.Phe374Leu variants are strong melanoma risk predictors.

  19. The SLC45A2 gene analysis identified 1 novel mutation, p.D93N.

  20. Three mutational alleles, R278X and R52I of the TYR gene and C229Y of the SLC45A2 gene, are added to the mutational spectra of Korean patients with oculocutaneous albinism (OCA)

Mouse (Murine) Solute Carrier Family 45, Member 2 (SLC45A2) interaction partners

  1. mRNA expression of SLC45A2 in eyes and skin and of SLC45A3 primarily in the prostate, but also in other tissues, whereas SLC45A4 showed a predominantly ubiquitous expression

SLC45A2 Protein Profile

Protein Summary

This gene encodes a transporter protein that mediates melanin synthesis. The protein is expressed in a high percentage of melanoma cell lines. Mutations in this gene are a cause of oculocutaneous albinism type 4, and polymorphisms in this gene are associated with variations in skin and hair color. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SLC45A2

  • solute carrier family 45 member 2 (SLC45A2)
  • solute carrier family 45 member 2 (slc45a2)
  • solute carrier family 45, member 2 (slc45a2)
  • solute carrier family 45 member 2 L homeolog (slc45a2.L)
  • solute carrier family 45, member 2 (Slc45a2)
  • 1A1 protein
  • Aim-1 protein
  • Aim1 protein
  • blanc-sale protein
  • bls protein
  • Dbr protein
  • im:7138762 protein
  • Matp protein
  • MGC114950 protein
  • OCA4 protein
  • SHEP5 protein
  • SLC45A2 protein
  • uw protein

Protein level used designations for SLC45A2

solute carrier family 45, member 2 , membrane-associated transporter protein , membrane associated transporter protein , B , absent in melanoma 1 , alb , albino , oca4 , membrane-associated transporter protein-like , melanoma antigen AIM1 , membrane associated transporter , protein AIM-1 , underwhite , B/AIM-1-like protein , dominant brown , protein underwhite , Membrane-associated transporter protein

431665 Gallus gallus
471584 Pan troglodytes
496798 Xenopus (Silurana) tropicalis
558311 Danio rerio
698246 Macaca mulatta
734429 Xenopus laevis
100228141 Taeniopygia guttata
100406055 Callithrix jacchus
100483846 Ailuropoda melanoleuca
100584203 Nomascus leucogenys
51151 Homo sapiens
22293 Mus musculus
489236 Canis lupus familiaris
606748 Sus scrofa
538746 Bos taurus
310152 Rattus norvegicus
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