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This study shows for the first time that LPS inhibits colonic biotin uptake via decreasing membrane expression of its transporter and that these effects likely involve a CK2-mediated pathway.
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S. typhimurium infection inhibits intestinal biotin uptake by SLC5A6, and that the inhibition is mediated via the action of proinflammatory cytokines.
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SMVT-mediated transport is highly specific for R-(+)-alpha-lipoic acid.
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SLC5A6 is responsible for the supplies of biotin and pantothenic acid into the brain across the blood brain barrier.
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these studies demonstrated for the first time the functional and molecular expression of sodium dependent multivitamin transporter (SMVT) in human derived breast cancer (T47D) cells
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This study shows for the first time the functional and molecular presence of SMVT in immortalized human corneal epithelial (HCEC) and retinal pigment epithelial (D407) cells
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PCR analysis had confirmed the existence of FR-alpha, SMVT, and B ((0, +)) in Y-79 and ARPE-19 cells.
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This study for the first time confirms the molecular expression of SMVT and demonstrates that SMVT, responsible for biotin uptake, is functionally active in PC-3 prostate cancer cells
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Cys(294) is essential for the function of the human sodium-dependent multivitamin transporter.
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Human SMVT protein is glycosylated, and that glycosylation is important for its function. The study also shows a role for the putative PKC-phosphorylation site Thr(286) of hSMVT in the PKC-mediated regulation of biotin uptake.
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PDZD11 is an interacting partner with hSMVT in intestinal epithelial cells and that this interaction affects hSMVT function and cell biology.
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These results show important role for His(1)(1) and His(2) residues in hSMVT function, which is most probably mediated via an effect on level of hSMVT expression at the cell membrane.
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hSMVT may play an important role in the homeostasis of I(-) in the body
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in intestinal and liver epithelial cells, SMVT is the major (if not the only) biotin uptake system that operates.
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biotin uptake by human renal epithelial cells occurs via the hSMVT system and that the process is regulated by intracellular PKC- and Ca(2+)/calmodulin-mediated pathways.
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A sodium-dependent multivitamin transporter, SMVT, responsible for biotin uptake and transport, was identified and functionally characterized in MDCK-MDR1 cells.
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Human intestinal biotin uptake is adaptively regulated but is not mediated via changes in hSMVT RNA stability.
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KLF-4 and AP-2 is regulating the activity of the hSMVT promoter in the intestine and provide direct in vivo confirmation of hSMVT promoter activity.
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findings from this study are consistent with the theory that HCS senses biotin, and that biotin regulates its own cellular uptake by participating in HCS-dependent chromatin remodeling events at the SMVT promoter 1 locus in Jurkat cells.
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Conclude that the COOH tail of hSMVT contains several determinants important for polarized targeting and biotin transport in epithelial cells.
