Protein Summary

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. May play a specialized role in the kidney in rectifying cell volume in response to extreme fluctuations of hyperosmolar-stimulated cell shrinkage. Is relatively amiloride and ethylisopropylamiloride (EIPA) insensitive. Can be activated under conditions of hyperosmolar-induced cell shrinkage in a sustained intracellular acidification-dependence manner. Activated by 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) in a sustained intracellular acidification-dependence manner. Affects potassium/proton exchange as well as sodium/proton and lithium/proton exchange. In basolateral cell membrane, participates in homeostatic control of intracellular pH, and may play a role in proton extrusion in order to achieve transepithelial HCO3(-) secretion. In apical cell membrane may be involved in mediating sodium absorption. Requires for normal levels of gastric acid secretion, secretory membrane development, parietal cell maturation and/or differentiation and at least secondarily for chief cell differentiation.

Gene names and symbols associated with SLC9A4

• solute carrier family 9 member A4 (SLC9A4) antibody
• solute carrier family 9 member A4 (slc9a4) antibody
• solute carrier family 9 (sodium/hydrogen exchanger), member 4 (Slc9a4) antibody
• solute carrier family 9 member A4 (Slc9a4) antibody

• AW990558 antibody
• D730009J23Rik antibody
• Nhe4 antibody
• SLC9A2 antibody

Protein level used designations for SLC9A4

solute carrier family 9 (sodium/hydrogen exchanger), member 4 , Na+/H+ exchanger , solute carrier family 9 (sodium/hydrogen exchanger), member 2 , sodium/hydrogen exchanger 4-like , NHE-4 , Na(+)/H(+) exchanger 4 , sodium/hydrogen exchanger 4 , solute carrier family 9 member 4 , solute carrier family 9 (sodium/hydrogen exchanger) , Solute carrier family 9 (sodium/hydrogen exchanger) , solute carrier family 9 (sodium/hydrogen exchanger) isoform 4 , solute carrier family 9, member 4