Somatostatin Receptor 2 Proteins (SSTR2)

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. Additionally we are shipping Somatostatin Receptor 2 Antibodies (91) and Somatostatin Receptor 2 Kits (14) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SSTR2 6752 P30874
Rat SSTR2 SSTR2 54305 P30680
SSTR2 20606 P30875
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Top Somatostatin Receptor 2 Proteins at

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg 50 to 55 Days
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg 50 to 55 Days
Wheat germ Human GST tag 10 μg 11 to 12 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
Escherichia coli (E. coli) Human His tag   50 μg 13 to 16 Days
Wheat germ Human Un-conjugated   2 μg 11 to 12 Days
Escherichia coli (E. coli) Human Un-conjugated   1 mg 11 to 16 Days

SSTR2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine)

More Proteins for Somatostatin Receptor 2 (SSTR2) Interaction Partners

Human Somatostatin Receptor 2 (SSTR2) interaction partners

  1. Minute pulmonary meningothelial-like nodules cells closely resemble SSTR2a-positive meningothelial cells.

  2. In this cohort showed that most IDH-wild type gliomas did not express SSTR2A protein and a significant overexpression of SSTR2A protein was observed in the IDH-mutant gliomas

  3. Olfactory neuroblastoma demonstrate high SSTR2a expression regardless of their differentiation.

  4. SSTR2 is a poor prognostic biomarker in SCLC and potential future therapeutic signaling target.

  5. SSTR2A expression is correlated with longer OS in medullary thyroid carcinoma, especially for stage IV patients, suggesting that SSTR2A expression might be a useful prognostic factor in medullary thyroid carcinoma.

  6. This study indicates a down-regulation of SSTR2 expression as small intestinal neuroendocrine tumors progress through the intestinal wall, which might signify underlying biological processes of importance for SI-NET invasion behavior.

  7. SSTR2A expression is infrequent in astrocytomas and negative in the majority of glioblastomas where it is of no prognostic significance. In contrast, oligodendrogliomas show intense membranous and cytoplasmic SSTR2A expression.

  8. The results of this study showed the SSTR2 expression was lower in patients pretreated with LA-SSA/PEGV compared to the drug-naive acromegalic patients.

  9. SSTR2 was significantly hypermethylated in colorectal cancer tissues when compared with adjacent normal colorectal tissues.

  10. This study investigated the presence of progenitor/stem cells in non-functioning pituitary tumors (NFPTs) and tested the efficacy of dopamine receptor type 2 (DRD2) and somatostatin receptor type 2 (SSTR2) agonists to inhibit in vitro proliferation

  11. expression of MDM2, somatostatin receptor 2A, and PD-L1 in follicular dendritic cell sarcoma

  12. Combination treatment increased both SSTR2 and SSTR5 mRNA and protein levels in DU-145 cells. The data suggest that this combination therapy may be a good candidate for patients with advanced metastatic Prostate cancer (PCa) do not respond to androgen deprivation.

  13. although the limited number of cases with adequate term follow-up, SSTR-2A expression could be a prognostic factor and somatostatin analogs therapeutic candidate for SmCCs of the bladder as these tumors show high percentage of SSTR-2A expression

  14. SSTR2 expression was tested in GH-secreting adenomas from 60 patients with acromegaly who had undergone pituitary surgery, 36 of whom had received octreotide with varying levels of response. Its expression was not correlated with baseline or post-octreotide GH or IGF-1 levels or tumor volume.

  15. Filamin-A is required to mediate SSTR2 effects in pancreatic neuroendocrine tumours

  16. Data showed that the distribution of somatostatin receptor (SSTR) subtypes among the 199 pancreatic neuroendocrine tumors (PNETs) was: SSTR2 (54.8%), SSTR1 (53.3%), SSTR4 (51.8%), SSTR5 (33.7%), and SSTR3 (28.6%).

  17. SSTR2 promoter hypermethylation might be associated with the risk and progression of laryngeal squamous cell carcinoma in males.

  18. VPA was observed to stimulate the expression of somatostatin receptor type 2 (SSTR2).

  19. Results show that histological subtyping of pituitary tumor correlated with SSTR2, E cadherin and p27kip protein levels and these may serve as useful biomarkers for prognosis.

  20. there is an elevation in CXCR4 and a decrease in SSTR2A expression with increasing malignancy in gastroenteropancreatic neuroendocrine neoplasms

Mouse (Murine) Somatostatin Receptor 2 (SSTR2) interaction partners

  1. Unpredictable chronic mild stress (UCMS) caused neuroendocrine changes, physical deteriorations, increased anxiety- and depressive-like behaviors and working memory impairments. sst2KO mice displayed behavioral alterations which were similar to stressed WT and exhibited exacerbated changes following UCMS exposure. The evaluations performed in the older mice showed significant long-term effects of UCMS exposure.

  2. SSTR2 is mainly expressed in distal tubules and collecting ducts in murine kidneys, and the expression of SSTR2 decreases during cyst growth in two polycystic kidney disease mouse models

  3. Both hippocampal sst2 and sst4 receptors selectively inhibit stress-induced HPA axis activation but mediate anxiolytic and antidepressive effects through distinct mechanisms.

  4. Loss of sst2 from pancreatic tissues activates PI3K signaling via AKT, leading to activation of NF-kappaB, amplification of oncogenic KRAS signaling, increased expression of CXCL16, and pancreatic tumor formation.

  5. The expression and localization of the three receptors (SSTR3-SSTR5) in wild-type (WT), single-knockout (SSTR1 KO) and double-knockout SSTR1/SSTR2 (DKO) mice, are reported.

  6. SST2 expression protects against gentamicin-induced auditory hair cell loss in the mammalian inner ear.

  7. Knock-down of SSTR2 leads to loss of pluripotency in murine embryonic stem cells.

  8. Inhibition of the Sstr2 receptor reversed the anticonvulsant effect mediated by cortistatin-14.

  9. OCT-P407 induces mRNA expression of SSTR-2 and caspase-3 and decreases that of VEGF in mice.

  10. The study encourages the use of liver tissue SSR2 protein and mRNA as a reliable tumor marker for liver cancer

  11. when activated by SST-14, SSTR2A internalizes and recycles via the Golgi, which requires ECE-1 degradation of SST-14 and receptor dissociation from beta-arrestins

  12. Findings suggest that somatostatin and its receptors (SSTR2 and SSTR5) are important markers in the regulation and development of Sertoli cell.

  13. The aim of this study was to validate an animal model expressing SSTR2 and to correlate the immunohistochemical (IHC) analysis with (18)F-FDG and (68)Ga-DOTATOC uptake in vivo.

  14. SSTR2 was expressed in Kolliker's organ on E14, on cochlear duct hair cells & supporting cells on E17 and only on the organ of Corti at birth, increasing & peaking at P14 but dropping off at P21.

  15. SSTR2 was well expressed in most of the hypothalamic regions whereas it decreases significantly in ventromedial and arcuate nucleus of ApoD(-/-) mice.

  16. sst2 may protect retinal cells from hypoxia, thus implementing the background to establish potential pharmacological targets.

  17. somatostatin receptors demonstrate specific expression in HCs and supporting cells of the mouse cochlea, and that absence of SST1 alters the expression of SST2.

  18. SSTR2-based reporters can serve as reporters of gene transfer into non-small cell lung cancer.

  19. Overexpressed in endomterium inendometriosis.

  20. sst(2a) and sst(4) were respectively detected in the dentate gyrus (DG) and the CA1 subfield suggesting that their functional interactions are not mediated by direct receptor coupling

Cow (Bovine) Somatostatin Receptor 2 (SSTR2) interaction partners

  1. Follicle-stimulating hormone regulates the SSTR2 protein expression in bovine granulosa cells.

Pig (Porcine) Somatostatin Receptor 2 (SSTR2) interaction partners

  1. SRIF can inhibit testosterone secretion through the sst2A receptor; local inhibitory action of SRIF is probably autocrine & might involve testosterone-induced increase of sst2 receptor expression in immature Leydig cells [SST2A]

  2. is a potent inhibitory receptor displaying a unique set of interrelated dynamic features of agonist-dependent dimerization, dissociation, internalization, and reassociation, a cascade of events that might be critical for receptor function

  3. Data demonstrate that urotensin II and urotensin II-related peptide directly activate somatostatin receptors 2 and 5 and thus mimic the effect of somatostatin on its cognate receptors.

Rhesus Monkey Somatostatin Receptor 2 (SSTR2) interaction partners

  1. Somatostatin directly promoted spontaneous contractions of the circular muscle of macaque intestine via mediation of SSTR2 in myenteric nerve plexus between the longitudinal and the circular muscle.

Guinea Pig Somatostatin Receptor 2 (SSTR2) interaction partners

  1. 5-HT(1A), SST(1), and SST(2) receptors mediate nonadrenergic IPSPs in the noncholinergic (VIP) secretomotor neurons of the submucous plexus of the guinea pig ileum.

Somatostatin Receptor 2 (SSTR2) Protein Profile

Protein Summary

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney.

Gene names and symbols associated with SSTR2

  • somatostatin receptor 2 (SSTR2)
  • somatostatin receptor 2 (Sstr2)
  • somatostatin receptor 2 L homeolog (sstr2.L)
  • MGC80373 protein
  • Smstr-2 protein
  • Smstr2 protein
  • SS2R protein
  • sst2 protein
  • SSTR-2 protein
  • SSTR2 protein

Protein level used designations for SSTR2

SRIF-1 , SS2R , somatostatin receptor type 2 , SS-2-R , SS2-R , somatostatin receptor subtype 2 , somatotropin release-inhibiting factor receptor , somatostatin receptor 2 , somatostatin type 2 receptor , somatostatin receptor type 2-like

6752 Homo sapiens
54305 Rattus norvegicus
20606 Mus musculus
282083 Bos taurus
395305 Gallus gallus
403472 Canis lupus familiaris
443137 Ovis aries
443970 Xenopus laevis
454854 Pan troglodytes
497059 Sus scrofa
695526 Macaca mulatta
100455484 Pongo abelii
100605186 Nomascus leucogenys
100723875 Cavia porcellus
100356395 Oryctolagus cuniculus
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