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SNX10 encodes a member of the sorting nexin family. Additionally we are shipping SNX10 Proteins (5) and many more products for this protein.
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supplementation with calcium gluconate rescued mice from the rachitic phenotype and extended life span in global Snx10-deficient mice, suggesting that this may be a life-saving component of the clinical approach to Snx10-dependent human osteopetrosis (show CSF1 Antibodies)
Data suggest Tyr32 and Arg51 in SNX10 are important for protein stability and play critical roles in vacuolation in osteoclasts; mutation Arg16Leu (seen in autosomal recessive osteopetrosis (show CSF1 Antibodies) patients) affects protein-protein interactions of SNX10.
results confirm the involvement of the SNX10 gene in human ARO (show CYP19A1 Antibodies) and identify a new subset with a relatively favorable prognosis as compared to TCIRG1 (show TCIRG1 Antibodies)-dependent cases
Structure of sorting nexin 11 (SNX11 (show SNX11 Antibodies)) reveals a novel extended phox homology (PX) domain critical for inhibition of SNX10-induced vacuolation.
Identification of SNX10 as a new osteopetrosis (show CSF1 Antibodies) associated gene in consanguineous families of Palestinian origin.
SNX10 regulates the ciliary trafficking of Rab8a (show RAB8A Antibodies), which is a critical regulator of ciliary membrane extension.
SNX10 activity may be involved in the regulation of endosome homeostasis
SNX10 plays an important role in the bone destruction of collagen-induced arthritis mice.
data disclose a crucial role and novel function for SNX10 in macrophage polarization. Loss of SNX10 function may be a potential promising therapeutic strategy for IBD.
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene may play a role in regulating endosome homeostasis. Alternative splicing results in multiple transcript variants.
sorting nexin 10
, sorting nexin-10