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SNX2 encodes a member of the sorting nexin family.
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SNX2 is highly expressed in 73.3% Graves disease patients and in 93.8% thyroid nodule patients.
Silencing of SNX2 markedly alters sensitivity to anticancer drugs targeted to c-Met.
SNX1 and SNX2 interact with the Rac1 and RhoG guanine nucleotide exchange factor Kalirin-7. Overexpression of SNX1 or SNX2 and Kalirin-7 partially redistributes both SNXs to the plasma membrane, and results in RhoG-dependent lamellipodia formation.
Examined the effect of a PX domain-mutated SNX2 that is defective in vesicle localization on EGFR (show EGFR Antibodies) trafficking.
The N-terminal domain of Abs interacts with the phox homology (PX) domain of SNX2 suggesting that PX domains may also participate in protein-protein interaction
Data suggest that sorting nexin-2 is not essential for the regulation of endosome-to-trans Golgi network retrieval of the cation-independent mannose 6-phosphate receptor (show IGF2R Antibodies).
These observations indicate that the mammalian retromer complex assembles by sequential association of SNX1 (show SNX1 Antibodies)/2 and Vps26 (show VPS26A Antibodies)-Vps29 (show VPS29 Antibodies)-Vps35 (show vps35 Antibodies) subcomplexes on endosomal membranes and that SNX1 (show SNX1 Antibodies) and SNX2 play interchangeable but essential roles.
study indicates that hVps34 (show PIK3C3 Antibodies) and its product PI(3 (show PI3 Antibodies))P are involved in endosome to Golgi transport of ricin, and that SNX2 and SNX4 (show SNX4 Antibodies) are likely to be effectors in this pathway
BLOS1 (show BLOC1S1 Antibodies) interacts with sorting nexin 2 and the ESCRT-I (show VPS28 Antibodies) component TSG101 (show TSG101 Antibodies) to mediate the sorting of EGFR (show EGFR Antibodies) into endosomal compartments
Data show that mice lacking sorting nexin 1 (show SNX1 Antibodies) or sorting nexin 2 are viable and fertile, whereas embryos deficient in both proteins arrest at midgestation.
Data describe a functional interaction between Hbeta58, sorting nexin 1 (SNX1 (show SNX1 Antibodies)), and SNX2 and strongly suggest that SNX2 plays a more critical role than SNX1 (show SNX1 Antibodies) in retromer activity during embryonic development.
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with formin-binding protein 17, but its function is unknown. This protein may form oligomeric complexes with family members.
sorting nexin 2
, sorting nexin-2
, sorting nexin-2-like
, transformation-related gene 9 protein