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Binds to GC boxes promoters elements. Additionally we are shipping Sp5 Transcription Factor Antibodies (8) and many more products for this protein.
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sp5 transcription factors mediate the downstream responses to Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling in several developmental processes in zebrafish.
human Sp5 is a member of Sp transcription factor family with a role in human cancers
In triple KO mice, the HO-induced lung injury was associated with decreased surfactant protein (SP) A (show SFTPA1 Proteins) and SPC (show SFTPC Proteins) but not SPB and SPD (show SFTPD Proteins) expression.
Functional studies revealed that knockdown of Nanog eliminated the mESC self-renewal-promoting ability of Sp5. Finally, we demonstrated that the self-renewal-promoting function of Sp5 was largely dependent on its zinc finger domains
an intricate link between caveolin-1 (show CAV1 Proteins) and Src kinase (show CSK Proteins)-mediated cell signaling and alveolar epithelial cell apoptosis due to loss of SP-C (show SFTPC Proteins) expression through p53 (show TP53 Proteins) and uPA (show PLAU Proteins) system-mediated cross-talk, is reported.
Sp5 is able to convert mouse epiblast stem cells into a naive pluripotent state.
Sp5/8 bind directly to GC boxes in Wnt (show WNT2 Proteins) target gene enhancers and to adjacent, or distally positioned, chromatin-bound T-cell factor (Tcf) 1 (show HNF1A Proteins)/lymphoid enhancer factor (Lef) 1 (show LEF1 Proteins) to facilitate recruitment of beta-catenin (show CTNNB1 Proteins) to target gene enhancers.
Sp5 and Sp8 (show SP8 Proteins) are pivotal downstream effectors of Wnt3a (show WNT3A Proteins)/beta-catenin (show CTNNB1 Proteins) that are essential for the self-renewal and differentiation of neuromesodermal stem cells.
Data suggests that different SP-C (show SFTPC Proteins) mutations have unique consequences for interstitial lung diseases. Mutations here resulted in aberrant proSP-c products
In vivo deficiency of SP-C (show SFTPC Proteins) leads to inflammation, increased cytokine production by type II cells, and persistent inflammation after repetitive LPS (show TLR4 Proteins) stimulation.
Transgenic restoration of SP-C (show SFTPC Proteins) reduces inflammation and improves viral clearance in the lungs of SP-C (show SFTPC Proteins) deficient mice.
The SPC H2B-GFP allele allowed the FACS-based enrichment and gene expression profiling of AT2 cells.
Binds to GC boxes promoters elements. Probable transcriptional activator that has a role in the coordination of changes in transcription required to generate pattern in the developing embryo (By similarity).
transcription factor Sp5
, trans-acting transcription factor 5
, Sp5 transcription factor