anti-Sp7 Transcription Factor (SP7) Antibodies

SP7 encodes a member of the Sp subfamily of Sp/XKLF transcription factors.

list all antibodies Gene Name GeneID UniProt
Anti-Human SP7 SP7 121340 Q8TDD2
Anti-Rat SP7 SP7 300260  
Anti-Mouse SP7 SP7 170574 Q8VI67
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Top anti-SP7 Antibodies at antibodies-online.com

Showing 10 out of 42 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB Host:  Rabbit  Target Name:  SP7  Sample Type:  Jurkat Whole Cell lysates  Antibody Dilution:  1.0ug/ml Host:  Rabbit  Target Name:  SP7  Sample Type:  Jurkat Whole Cell lysates  Antibody Dilution:  0.5ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB Immunohistochemistry with Testis tissue at an antibody concentration of 5µg/ml using anti-SP7 antibody (ARP32231_P050) Host:  Rabbit  Target Name:  SP7  Sample Tissue:  Human Fetal Lung  Antibody Dilution:  1.0ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB Host:  Rabbit  Target Name:  Sp7  Sample Type:  Rat Testis lysates  Antibody Dilution:  1.0ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded mouse embryo labeled with Rabbit Anti Osterix Polyclonal Antibody, Unconjugated (ABIN737811) at 1:200 followed by conjugation to the secondary antibody and DAB staining Mouse spinal cord lysates probed with Osterix Polyclonal Antibody, unconjugated  at 1:300 overnight at 4°C followed by a conjugated secondary antibody for 60 minutes at 37°C. 100 μL Log in to see 3 to 7 Days
$318.45
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-SP7 Antibody Titration: 2.5 ug/ml Positive Control: Jurkat Whole Cell 100 μL Log in to see 2 to 3 Days
$229.00
Details
Cow Rabbit Un-conjugated WB 100 μg Log in to see 7 to 9 Days
$493.17
Details
Cow Rabbit Un-conjugated IHC, WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Mouse PE ICC, WB Western Blot (Negative): Osterix/Sp7 Antibody (764704) [PE] [NBP2-47615PE] - Analysis in Saos-2 human osteosarcoma cell line. Experiment was done in reducing conditions. Immunocytochemistry/Immunofluorescence: Osterix/Sp7 Antibody (764704) [PE] [NBP2-47615PE] - Analysis in Saos-2 human osteosarcoma cell line. Specific staining was localized to nuclei. 0.1 mL Log in to see 10 to 13 Days
$556.31
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged SP7 is approximately 1 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details

Top referenced anti-SP7 Antibodies

  1. Human Polyclonal SP7 Primary Antibody for IF (p), IHC (p) - ABIN737811 : Chen, Lazarenko, Zhang, Blackburn, Ronis, Badger: Diet-derived phenolic acids regulate osteoblast and adipocyte lineage commitment and differentiation in young mice. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2014 (PubMed)
    Show all 11 Pubmed References

  2. Cow (Bovine) Polyclonal SP7 Primary Antibody for IHC, WB - ABIN2777381 : Milona, Gough, Edgar: Expression of alternatively spliced isoforms of human Sp7 in osteoblast-like cells. in BMC genomics 2004 (PubMed)

More Antibodies against SP7 Interaction Partners

Human Sp7 Transcription Factor (SP7) interaction partners

  1. Results showed that blocking miR (show MLXIP Antibodies)-31 led to an increase in osterix protein in both cell types at day 7, with an increase in osteocalcin (show BGLAP Antibodies) at day 21, suggesting MSC (show MSC Antibodies) osteogenesis

  2. Results provide evidence that CBP (show CREBBP Antibodies)-mediated acetylation and HDAC4 (show HDAC4 Antibodies)-mediated deacetylation have critical roles in the modification of Osx (show MID1 Antibodies), and thus are important in osteoblast differentiation.

  3. Osterix and RUNX2 (show RUNX2 Antibodies) are transcriptional regulators of sclerostin (show SOST Antibodies) in human bone

  4. Osterix decreased the chemosensitivity of breast cancer cells by upregulating the expression of GALNT14 (show GALNT14 Antibodies), which eventually suppressed the apoptosis of breast cancer cells.

  5. TP(thymidine phosphorylase (show TYMP Antibodies) ) curbed the expression of three proteins-IRF8 (show IRF8 Antibodies), RUNX2 (show RUNX2 Antibodies), and osterix. This downregulation was epigenetically driven: High levels of 2DDR, a product of TP secreted by myeloma cells, activated PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) signaling and increased the methyltransferase DNMT3A's expression

  6. dissection of these interconnected epigenetic mechanisms that govern Sp7 gene activation reveals a hierarchical process where regulatory components mediating DNA demethylation play a leading role

  7. SP7 gene promoter is robustly enriched in epigenetic repressive marks that may explain its poor transcriptional response to osteoblast differentiating media in umbilical cord derived mesenchymal stem cells.

  8. Eight and five of the nine samples were negative for cell adhesion molecule 1 (show CADM1 Antibodies) and Osterix respectively. The other markers showed no statistical significance(CD151 (show CD151 Antibodies),ALP (show ALP Antibodies)). osteoblastic differentiation can occur in carcinoma cells and that cell adhesion molecule 1 (show CADM1 Antibodies) could be a useful marker for identifying this phenomenon in carcinoma tissues

  9. The results suggest that Osterix plays an important role in increasing BMP- 4 (show BMP4 Antibodies)-induced Cx43 (show GJA1 Antibodies) activity.

  10. The expression of specific targets Smad1 (show GARS Antibodies) and Osterix was significantly increased in the presence of Pi and restored by coincubation with Mg(2 (show MUC7 Antibodies)+). As miR (show MLXIP Antibodies)-30b, miR (show MLXIP Antibodies)-133a, and miR (show MLXIP Antibodies)-143 are negatively regulated by Pi and restored by Mg(2 (show MUC7 Antibodies)+) with a congruent modulation of their known targets Runx2 (show RUNX2 Antibodies), Smad1 (show GARS Antibodies), and Osterix, our results provide a potential mechanistic explanation of the observed upregulation of these master switches of o

Zebrafish Sp7 Transcription Factor (SP7) interaction partners

  1. In zebrafish lacking sp7, attachment bone is never present, independent of the stage of tooth development or fish age, yet replacement is not interrupted. There was abnormal orientation of teeth, and abnormal connection of pulp cavities of predecessor and replacement teeth, arrested dentinogenesis, non-polarization of odontoblasts and only a thin layer of dentin deposition.

  2. Sp7 plays a critical role in limiting the level of signaling and the rate of bone growth

  3. FGF and Wnt (show WNT2 Antibodies)/beta-Catenin (show CTNNB1 Antibodies) pathways act in part by directing transcription of osx to promote osteoblast differentiation at sites of bone formation.

  4. Data show the endogenous sp7 gene expression in the otic placode and vesicle, and in forming skeletal structures in Tg(sp7:EGFP)b1212 line.

Mouse (Murine) Sp7 Transcription Factor (SP7) interaction partners

  1. this study shows that Osterix represses adipogenesis by negatively regulating PPARgamma (show PPARG Antibodies) transcriptional activity

  2. these findings strongly suggest that TGF-beta (show TGFB1 Antibodies) signaling plays a major role as one of the upstream regulators of Osx in cementoblast differentiation and cementum formation

  3. These results suggest proliferation and maturation of immature osteoblasts requires Tgfbr2 (show TGFBR2 Antibodies) signaling and that decreased bone volume in Osx-Cre;Tgfbr2 (show TGFBR2 Antibodies)(fl/fl (show FLT3LG Antibodies)) mice is likely due to fewer mature osteoblasts.

  4. DNA damage and senescence in osteoprogenitors expressing Osx may cause their decrease with age.

  5. The data support a model in which Dlx recruitment of Sp7 to osteoblast enhancers underlies Sp7-directed osteoblast specification.

  6. Mmp13 (show MMP13 Antibodies) is selectively regulated of by 1,25-Dihydroxyvitamin D3, PTH (show PTH Antibodies), and Osterix through distal enhancers.

  7. These results indicated that olfactory bulb development was not significantly impaired in the absence of Osx.

  8. Wnt3a (show WNT3A Antibodies) induces Osx expression via p38 MAPK (show MAPK14 Antibodies) signaling in dental follicle cells. Wnt3a (show WNT3A Antibodies)-induced Osx expression was inhibited in the presence of p38 mitogen-activated protein kinase (show MAPK14 Antibodies) (MAPK (show MAPK1 Antibodies)) inhibitors (SB203580 and SB202190) at gene and protein levels, as assessed by real-time PCR and immunocytohistochemistry, respectively.

  9. Transfection assay demonstrated that Osx was able to activate Bsp (show KLK6 Antibodies) promoter reporter in a dose-dependent manner. To define minimal region of Bsp (show KLK6 Antibodies) promoter activated by Osx, a series of deletion mutants of Bsp (show KLK6 Antibodies) promoter were generated, and the minimal region was narrowed down to the proximal 100 bp. Point-mutagenesis studies showed that one GC-rich (show RELB Antibodies) site was required for Bsp (show KLK6 Antibodies) promoter activation by Osx.

  10. OSX served a key role in the development and progression of ALD (show ABCD1 Antibodies)-induced VSMC calcification. This observation may aid in the explanation of the role of OSX in the pathogenesis of vascular calcification

SP7 Antigen Profile

Protein Summary

This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.

Gene names and symbols associated with SP7

  • Sp7 transcription factor (SP7) antibody
  • Sp7 transcription factor (Sp7) antibody
  • Sp7 transcription factor (sp7) antibody
  • uncharacterized LOC100063836 (LOC100063836) antibody
  • Sp7 transcription factor L homeolog (sp7.L) antibody
  • Sp7 transcription factor 7 (Sp7) antibody
  • 6430578P22Rik antibody
  • C22 antibody
  • OI11 antibody
  • OI12 antibody
  • osterix antibody
  • osx antibody
  • sp7 antibody

Protein level used designations for SP7

transcription factor Sp7 , zinc finger protein osterix , osterix , transcription factor osterix , Sp7 transcription factor , transcription factor Sp7-like , trans-acting transcription factor 7 , Sp7 transcription factor 7

GENE ID SPECIES
121340 Homo sapiens
300260 Rattus norvegicus
405789 Danio rerio
467004 Pan troglodytes
531995 Bos taurus
607857 Canis lupus familiaris
702575 Macaca mulatta
100063836 Equus caballus
100101324 Xenopus laevis
100189548 Xenopus (Silurana) tropicalis
100407102 Callithrix jacchus
100587177 Nomascus leucogenys
170574 Mus musculus
404701 Sus scrofa
100732690 Cavia porcellus
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