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SP7 encodes a member of the Sp subfamily of Sp/XKLF transcription factors.
Showing 10 out of 42 products:
Human Polyclonal SP7 Primary Antibody for IF (p), IHC (p) - ABIN737811
Chen, Lazarenko, Zhang, Blackburn, Ronis, Badger: Diet-derived phenolic acids regulate osteoblast and adipocyte lineage commitment and differentiation in young mice. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2014
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Cow (Bovine) Polyclonal SP7 Primary Antibody for IHC, WB - ABIN2777381
Milona, Gough, Edgar: Expression of alternatively spliced isoforms of human Sp7 in osteoblast-like cells. in BMC genomics 2004
Results showed that blocking miR (show MLXIP Antibodies)-31 led to an increase in osterix protein in both cell types at day 7, with an increase in osteocalcin (show BGLAP Antibodies) at day 21, suggesting MSC (show MSC Antibodies) osteogenesis
Results provide evidence that CBP (show CREBBP Antibodies)-mediated acetylation and HDAC4 (show HDAC4 Antibodies)-mediated deacetylation have critical roles in the modification of Osx (show MID1 Antibodies), and thus are important in osteoblast differentiation.
Osterix and RUNX2 (show RUNX2 Antibodies) are transcriptional regulators of sclerostin (show SOST Antibodies) in human bone
Osterix decreased the chemosensitivity of breast cancer cells by upregulating the expression of GALNT14 (show GALNT14 Antibodies), which eventually suppressed the apoptosis of breast cancer cells.
TP(thymidine phosphorylase (show TYMP Antibodies) ) curbed the expression of three proteins-IRF8 (show IRF8 Antibodies), RUNX2 (show RUNX2 Antibodies), and osterix. This downregulation was epigenetically driven: High levels of 2DDR, a product of TP secreted by myeloma cells, activated PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) signaling and increased the methyltransferase DNMT3A's expression
dissection of these interconnected epigenetic mechanisms that govern Sp7 gene activation reveals a hierarchical process where regulatory components mediating DNA demethylation play a leading role
SP7 gene promoter is robustly enriched in epigenetic repressive marks that may explain its poor transcriptional response to osteoblast differentiating media in umbilical cord derived mesenchymal stem cells.
Eight and five of the nine samples were negative for cell adhesion molecule 1 (show CADM1 Antibodies) and Osterix respectively. The other markers showed no statistical significance(CD151 (show CD151 Antibodies),ALP (show ALP Antibodies)). osteoblastic differentiation can occur in carcinoma cells and that cell adhesion molecule 1 (show CADM1 Antibodies) could be a useful marker for identifying this phenomenon in carcinoma tissues
The results suggest that Osterix plays an important role in increasing BMP- 4 (show BMP4 Antibodies)-induced Cx43 (show GJA1 Antibodies) activity.
The expression of specific targets Smad1 (show GARS Antibodies) and Osterix was significantly increased in the presence of Pi and restored by coincubation with Mg(2 (show MUC7 Antibodies)+). As miR (show MLXIP Antibodies)-30b, miR (show MLXIP Antibodies)-133a, and miR (show MLXIP Antibodies)-143 are negatively regulated by Pi and restored by Mg(2 (show MUC7 Antibodies)+) with a congruent modulation of their known targets Runx2 (show RUNX2 Antibodies), Smad1 (show GARS Antibodies), and Osterix, our results provide a potential mechanistic explanation of the observed upregulation of these master switches of o
In zebrafish lacking sp7, attachment bone is never present, independent of the stage of tooth development or fish age, yet replacement is not interrupted. There was abnormal orientation of teeth, and abnormal connection of pulp cavities of predecessor and replacement teeth, arrested dentinogenesis, non-polarization of odontoblasts and only a thin layer of dentin deposition.
Sp7 plays a critical role in limiting the level of signaling and the rate of bone growth
FGF and Wnt (show WNT2 Antibodies)/beta-Catenin (show CTNNB1 Antibodies) pathways act in part by directing transcription of osx to promote osteoblast differentiation at sites of bone formation.
Data show the endogenous sp7 gene expression in the otic placode and vesicle, and in forming skeletal structures in Tg(sp7:EGFP)b1212 line.
this study shows that Osterix represses adipogenesis by negatively regulating PPARgamma (show PPARG Antibodies) transcriptional activity
these findings strongly suggest that TGF-beta (show TGFB1 Antibodies) signaling plays a major role as one of the upstream regulators of Osx in cementoblast differentiation and cementum formation
These results suggest proliferation and maturation of immature osteoblasts requires Tgfbr2 (show TGFBR2 Antibodies) signaling and that decreased bone volume in Osx-Cre;Tgfbr2 (show TGFBR2 Antibodies)(fl/fl (show FLT3LG Antibodies)) mice is likely due to fewer mature osteoblasts.
DNA damage and senescence in osteoprogenitors expressing Osx may cause their decrease with age.
The data support a model in which Dlx recruitment of Sp7 to osteoblast enhancers underlies Sp7-directed osteoblast specification.
Mmp13 (show MMP13 Antibodies) is selectively regulated of by 1,25-Dihydroxyvitamin D3, PTH (show PTH Antibodies), and Osterix through distal enhancers.
These results indicated that olfactory bulb development was not significantly impaired in the absence of Osx.
Wnt3a (show WNT3A Antibodies) induces Osx expression via p38 MAPK (show MAPK14 Antibodies) signaling in dental follicle cells. Wnt3a (show WNT3A Antibodies)-induced Osx expression was inhibited in the presence of p38 mitogen-activated protein kinase (show MAPK14 Antibodies) (MAPK (show MAPK1 Antibodies)) inhibitors (SB203580 and SB202190) at gene and protein levels, as assessed by real-time PCR and immunocytohistochemistry, respectively.
Transfection assay demonstrated that Osx was able to activate Bsp (show KLK6 Antibodies) promoter reporter in a dose-dependent manner. To define minimal region of Bsp (show KLK6 Antibodies) promoter activated by Osx, a series of deletion mutants of Bsp (show KLK6 Antibodies) promoter were generated, and the minimal region was narrowed down to the proximal 100 bp. Point-mutagenesis studies showed that one GC-rich (show RELB Antibodies) site was required for Bsp (show KLK6 Antibodies) promoter activation by Osx.
OSX served a key role in the development and progression of ALD (show ABCD1 Antibodies)-induced VSMC calcification. This observation may aid in the explanation of the role of OSX in the pathogenesis of vascular calcification
This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.
transcription factor Sp7
, zinc finger protein osterix
, transcription factor osterix
, Sp7 transcription factor
, transcription factor Sp7-like
, trans-acting transcription factor 7
, Sp7 transcription factor 7