anti-Spastic Ataxia of Charlevoix-Saguenay (Sacsin) Antibodies

SACS encodes the sacsin protein, which includes a UbL domain at the N-terminus, a DnaJ domain, and a HEPN domain at the C-terminus.

Data Quality
  • 2
Type
  • 9
    Primary antibodies
Antigen
  • 9
Reactivity
  • 9
  • 3
  • 2
Application
  • 6
  • 3
  • 3
  • 2
Host
  • 8
  • 1
Clonality
  • 9
Binding Specificity
  • 4
  • 1
  • 1
  • 1
  • 1
Conjugate
  • 6
  • 1
  • 1
  • 1
Isotype
  • 7
Format
  • 6
  • 2
9 Products
ReactivityHuman, Mouse (Murine), Rat (Rattus)
Application ELISA, IHC, WB
Order details Cat. No. ABIN5693301
$280.00
100 μg
Plus shipping costs $45.00
Delivery in 4 to 6 Business Days
ReactivityHuman, Mouse (Murine), Rat (Rattus)
Application ELISA, IHC (p), WB
Order details Cat. No. ABIN5708501
$452.38
100 μg
Plus shipping costs $45.00
Delivery in 2 to 3 Business Days
ReactivityHuman, Mouse (Murine)
Application IHC (p)
Order details Cat. No. ABIN6390208
$341.69
Plus shipping costs $45.00
Delivery in 11 to 13 Business Days
ReactivityHuman
Application WB
Order details Cat. No. ABIN5673657
$229.00
100 μL
Plus shipping costs $45.00
Delivery in 2 to 3 Business Days
ReactivityHuman
Application IHC
Order details Cat. No. ABIN1982323
$329.85
50 μg
Plus shipping costs $45.00
Delivery in 2 to 3 Business Days
ReactivityHuman
Application ELISA, IHC
Order details Cat. No. ABIN6107112
$464.30
Plus shipping costs $45.00
Delivery in 11 to 16 Business Days
ReactivityHuman
Application ELISA
Order details Cat. No. ABIN6113843
$464.30
Plus shipping costs $45.00
Delivery in 11 to 16 Business Days
ReactivityHuman
Application ELISA
Order details Cat. No. ABIN6113841
$464.30
Plus shipping costs $45.00
Delivery in 11 to 16 Business Days
ReactivityHuman
Application ELISA
Order details Cat. No. ABIN6113845
$464.30
Plus shipping costs $45.00
Delivery in 11 to 16 Business Days
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Spastic Ataxia of Charlevoix-Saguenay (Sacsin) (SACS) Antigen Profile

Protein Summary

This gene encodes the sacsin protein, which includes a UbL domain at the N-terminus, a DnaJ domain, and a HEPN domain at the C-terminus. The gene is highly expressed in the central nervous system, also found in skin, skeletal muscles and at low levels in the pancreas. This gene includes a very large exon spanning more than 12.8 kb. Mutations in this gene result in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), a neurodegenerative disorder characterized by early-onset cerebellar ataxia with spasticity and peripheral neuropathy. The authors of a publication on the effects of siRNA-mediated sacsin knockdown concluded that sacsin protects against mutant ataxin-1 and suggest that 'the large multi-domain sacsin protein is able to recruit Hsp70 chaperone action and has the potential to regulate the effects of other ataxia proteins' (Parfitt et al., PubMed: 19208651).

Gene names and symbols associated with SACS

  • sacsin (Sacs) antibody
  • sacsin molecular chaperone (SACS) antibody
  • A230052M14 antibody
  • ARSACS antibody
  • DNAJC29 antibody
  • E130115J16Rik antibody
  • mKIAA0730 antibody

Protein level used designations for SACS

dnaJ homolog subfamily C member 29 , sacsin

GENE ID SPECIES
50720 Mus musculus
26278 Homo sapiens
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