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may have a role in spermatogenesis [RGD, Feb 2006].. Additionally we are shipping SPDYA Antibodies (33) and SPDYA Kits (6) and many more products for this protein.
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Identified a telomere localization domain on Speedy A covering the distal N terminus and the Cdk2-binding Ringo domain, and this domain is essential for the localization of Speedy A to telomeres.
RingoA is an important activator of Cdk2 (show CDK2 Proteins) at meiotic telomeres.
the Spy1/RINGO family of proteins may play an essential role in regulating both normal and abnormal growth processes in the breast
Authors demonstrate that mammalian Spy1-mediated ERK (show EPHB2 Proteins) activation increases ligand-independent phosphorylation and activation of estrogen receptor alpha (show ESR1 Proteins), correlating with a decrease in tamoxifen sensitivity.
The authors find that Spy1 confers structural changes to Cdk2 (show CDK2 Proteins) that obviate the requirement of Cdk (show CDK4 Proteins) activation loop phosphorylation.
CRMP1 (show CRMP1 Proteins) interacted with Spy1 which would disturb the association of CRMP1 (show CRMP1 Proteins) with actin and was involved in the collapse of growth cones induced by Sema3A (show SEMA3A Proteins) and regeneration after sciatic nerve crush.
Spy1 participates in the proliferation and apoptosis of epithelial ovarian cancer.
A novel Spy1-CLIPR-59 (show CLIP3 Proteins) interplay was identified in glioblastoma resistance to TNF-alpha (show TNF Proteins).
Cell adhesion to fibronectin down-regulates the expression of Spy1 and contributes to drug resistance in multiple myeloma cells.
we demonstrate that the atypical cyclin-like protein Spy1 plays a role in balancing the division properties of glioma cells with stemness properties
Our results suggest that Spy1 may be a possible prognostic indicator in NHLs, and it was correlated with phosphorylation of p27(Kip1 (show CDKN1B Proteins)) on Thr187
Spy1 expression positively correlates with the malignancy of gliomas.
This study reports that Spy1 expression allows cells to evade checkpoints and apoptosis and suggest that Spy1 regulation of CDK2 (show CDK2 Proteins) is important for the response to DNA damage.
may have a role in spermatogenesis
speedy homolog A (Xenopus laevis)
, speedy protein A
, speedy 1
, RINGO A
, mSpy/Ringo A
, protein expressed in male leptotene and zygotene spermatocytes 465
, rapid inducer of G2/M progression in oocytes A
, speedy A
, speedy A1
, speedy A2
, speedy homolog 1
, spermatogenesis related protein Gs4
, rapid inducer of G2/M progression in oocytes
, hSpy/Ringo A
, speedy homolog A