Sperm Associated Antigen 11B Proteins (SPAG11B)

SPAG11B encodes several androgen-dependent, epididymis-specific secretory proteins. Additionally we are shipping Sperm Associated Antigen 11B Antibodies (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SPAG11B 10407 Q6PDA7 , Q08648
Rat SPAG11B SPAG11B 246305 Q8VBV2
SPAG11B 546038 Q8K4N2
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Top Sperm Associated Antigen 11B Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days

SPAG11B Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for Sperm Associated Antigen 11B (SPAG11B) Interaction Partners

Human Sperm Associated Antigen 11B (SPAG11B) interaction partners

  1. we report the three dimensional structure of the human SPAG11B proteins and their C-terminal peptides. web-based hydropathy, amphipathicity, and topology (WHAT) analyses and grand average of hydropathy

  2. Isoform C of SPAG11B encodes a peptide with antimicrobial activity against E. coli.

  3. Combination of two proteins, SPAG11B and TEX101, can be used for differential diagnosis of azoospermia

  4. SPAG11B/D is both a substrate and a potent inhibitor of TPSAB1 activity.

  5. HE2 peptides were detected in human epididymal epithelium, epididymal fluid, and ejaculate

  6. HE2 transcriptional and translational products normally expressed in the caput epididymidis were not affected by vasectomy.

  7. EP2 expression is more widespread in male reproductive tract than realized previously. Activity of every EP2 variant tested is antibacterial. Further investigation may reveal additional roles for EP2 peptides in primate male reproductive tract.

  8. In the chimpanzee epididymis, several mRNA HE2/EP2 variants are produced. Of these, three cDNAs code for two different protein sequences that have a cysteine distribution characteristic for beta-defensins.

  9. The human HE2/EP2 gene is the fusion product of two ancestral beta-defensin genes. During its evolution, the gene has acquired additional exons whose inclusion produces new message variants that encode peptides unrelated to defensins.

Mouse (Murine) Sperm Associated Antigen 11B (SPAG11B) interaction partners

  1. Data suggest that Spag11a has a specific role in epididymal sperm maturation.

  2. Model was developed in which Bin1b was exclusively overexpressed by up to 50-fold in the caput epididymis. The transgenic mice are healthy with normal reproductive activity, but are more resistant to epididymal infection from E coli than normal animals.

  3. increased expression in response to lipopolysaccharide administration

  4. The epididymis-specific expression pattern of the beta-defensin isoform EP2e has been characterized.

Cow (Bovine) Sperm Associated Antigen 11B (SPAG11B) interaction partners

  1. SPAG11 isoforms perform both immune and reproductive functions in cattle.

Sperm Associated Antigen 11B (SPAG11B) Protein Profile

Protein Summary

This gene encodes several androgen-dependent, epididymis-specific secretory proteins. The specific functions of these proteins have not been determined, but they are thought to be involved in sperm maturation. Some of the isoforms contain regions of similarity to beta-defensins, a family of antimicrobial peptides. The gene is located on chromosome 8p23 near the defensin gene cluster. Alternative splicing of this gene results in seven transcript variants encoding different isoforms. Two different N-terminal and five different C-terminal protein sequences are encoded by the splice variants. Two additional variants have been described, but their full length sequences have not been determined.

Gene names and symbols associated with SPAG11B

  • sperm associated antigen 11B (SPAG11B)
  • sperm associated antigen 11A (Spag11a)
  • sperm associated antigen 11B (Spag11b)
  • 9230111C08Rik protein
  • Bin1b protein
  • EDDM2B protein
  • EG546038 protein
  • EP2 protein
  • EP2C protein
  • Ep2c/h protein
  • EP2D protein
  • EP2e protein
  • EP2Q protein
  • HE2 protein
  • HE2C protein
  • Spag11 protein
  • SPAG11B protein
  • Spag11c/h protein

Protein level used designations for SPAG11B

epididymal protein 2B , human epididymis-specific protein 2 , sperm antigen HE2 , sperm-associated antigen 11B , anti-microbial-like protein BIN-1B , antimicrobial-like protein Bin-1b , sperm associated antigen 11 , sperm-associated antigen 11 , beta-defensin-like peptide , sperm-associated antigen 11c/h , sperm associated antigen 11B , antimicrobial peptide Bin1b , beta defensin EP2e

10407 Homo sapiens
246305 Rattus norvegicus
546038 Mus musculus
783025 Bos taurus
100188900 Sus scrofa
78128 Mus musculus
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