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The mammalian sperm flagellum contains two cytoskeletal structures associated with the axoneme: the outer dense fibers surrounding the axoneme in the midpiece and principal piece and the fibrous sheath surrounding the outer dense fibers in the principal p. Additionally we are shipping Sperm Associated Antigen 4 Proteins (3) and and many more products for this protein.
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SPAG4, in cooperation with Nesprin3, has a fundamental pathological function in the migration of lung carcinoma cells.
SPAG4 knockdown reduces the invasion capability of RCC cells.
SPAG4 is an independent prognostic factor in renal cell carcinoma and plays a crucial role in cytokinesis to defend against hypoxia-induced tetraploid formation.
The results thus indicate that SPAG4, albeit not essential for the formation of the HTCA per se, is, nevertheless, required for tightening the sperm head-to-tail anchorage by provoking the correct attachment of the lateral parts of the basal plate to the implantation fossa.
SUN4, a spermatid nuclear membrane protein has an essential function in coupling the manchette to the nuclear periphery.
The mammalian sperm flagellum contains two cytoskeletal structures associated with the axoneme: the outer dense fibers surrounding the axoneme in the midpiece and principal piece and the fibrous sheath surrounding the outer dense fibers in the principal piece of the tail. Defects in these structures are associated with abnormal tail morphology, reduced sperm motility, and infertility. In the rat, the protein encoded by this gene associates with an outer dense fiber protein via a leucine zipper motif and localizes to the microtubules of the manchette and axoneme during sperm tail development.
sperm associated antigen 4
, sperm-associated antigen 4 protein
, SUN domain-containing protein 4
, Sad1 and UNC84 domain containing 4
, acrosomal protein ACR55
, cancer/testis antigen 127
, outer dense fiber-associated protein SPAG4
, sperm tail protein
, sperm antigen 4