anti-Sperm Associated Antigen 6 (SPAG6) Antibodies

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Additionally we are shipping Sperm Associated Antigen 6 Proteins (4) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SPAG6 9576 O75602
SPAG6 50525 Q9JLI7
SPAG6 360747  
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Top anti-Sperm Associated Antigen 6 Antibodies at antibodies-online.com

Showing 10 out of 44 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-SPAG6 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: HT1080 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-SPAG6 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: HepG2 cell lysate WB Suggested Anti-SPAG6  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Western Blot: SPAG6 Antibody [NBP1-80923] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Negative control (vector only transfected HEK293T lysate).Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY406761) Immunohistochemistry-Paraffin: SPAG6 Antibody [NBP1-80923] - Staining of human bronchus shows strong membranous positivity of cilia in respiratory epithelial cells. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Human Mouse Un-conjugated WB Western Blot analysis of SPAG6 expression in transfected 293T cell line by SPAG6 MaxPab polyclonal antibody.Lane 1: SPAG6 transfected lysate(55.99 KDa).Lane 2: Non-transfected lysate. 50 μL Log in to see 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated WB SPAG6 Antibody (C-term) (ABIN1881822) western blot analysis in MDA-MB453 cell line lysates (35 µg/lane). This demonstrates the SPAG6 antibody detected the SPAG6 protein (arrow). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated WB SPAG6 antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 9 to 11 Days
$473.93
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Western Blot: SPAG6 Antibody [NBP2-20462] - Sample (30 ug of whole cell lysate) A: U87-MG 7. 5% SDS PAGE gel, diluted at 1:1000. Immunohistochemistry-Paraffin: SPAG6 Antibody [NBP2-20462] - Immunohistochemical analysis of paraffin-embedded H441 xenograft, using antibody at 1:500 dilution. 0.1 mL Log in to see 8 to 11 Days
$516.98
Details
Human Mouse Un-conjugated ELISA, WB SPAG6 monoclonal antibody (M01), clone 3E3 Western Blot analysis of SPAG6 expression in A-431 . Western Blot detection against Immunogen (37.11 KDa) . 100 μg Log in to see 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated WB Western Blot analysis of SPAG6 expression in transfected 293T cell line by SPAG6 MaxPab polyclonal antibody.Lane 1: SPAG6 transfected lysate(55.50 KDa).Lane 2: Non-transfected lysate. 100 μg Log in to see 11 to 12 Days
$425.71
Details
Human Mouse Un-conjugated ELISA Detection limit for recombinant GST tagged SPAG6 is approximately 1ng/ml as a capture antibody. 100 μg Log in to see 11 to 12 Days
$440.00
Details

Top referenced anti-Sperm Associated Antigen 6 Antibodies

  1. Cow (Bovine) Polyclonal SPAG6 Primary Antibody for WB - ABIN2785513 : Mehrle, Rosenfelder, Schupp, del Val, Arlt, Hahne, Bechtel, Simpson, Hofmann, Hide, Glatting, Huber, Pepperkok, Poustka, Wiemann: The LIFEdb database in 2006. in Nucleic acids research 2005 (PubMed)

  2. Human Polyclonal SPAG6 Primary Antibody for WB - ABIN1881822 : Rao, Xia, Yang, Hu, Hu, Lei, Wu, Zhu: Transient scrotal hyperthermia affects human sperm DNA integrity, sperm apoptosis, and sperm protein expression. in Andrology 2017 (PubMed)

More Antibodies against Sperm Associated Antigen 6 Interaction Partners

Human Sperm Associated Antigen 6 (SPAG6) interaction partners

  1. Upregulation of SPAG6 is associated with Myelodysplastic Syndrome.

  2. These results demonstrate that SPAG6 silencing induces PTEN expression to regulate apoptosis though the PI3K/AKT pathway, indicating that SPAG6 may be a potential therapeutic target for myelodysplastic syndromes.

  3. SPAG6 and L1TD1 are tumor-specifically methylated in NSCLCs and that DNA methylation is involved in the transcriptional regulation of these genes. Moreover, in vitro as well as in vivo experiments revealed tumor-cell growth suppressing properties of L1TD1 in NSCLC cells.

  4. Study demonstrates that SPAG6 may regulate apoptosis through the TRAIL signal pathway by inhibiting the expression of FADD and the interactions between FADD and the TRAIL death receptors.

  5. studies demonstrate a role for Spag6 in the pathogenesis of OM in mice, possibly through its role in the regulation of cilia/basal body polarity through the PCP-dependent mechanisms in the middle ear and Eustachian tubes.

  6. These findings demonstrate that SPAG6 might have a role in malignant myeloid hematologic cell proliferation and apoptosis by regulating caspase proteins and p53, suggesting that SPAG6 may be a potential therapeutic target.

  7. SPAG6 is a S-SOX5 target gene, indicating a key role for S-SOX5 in the formation and function of motile cilia.

  8. Data describe the cloning of human and mouse Pf20 proteins that interact with Spag6 protein.

Mouse (Murine) Sperm Associated Antigen 6 (SPAG6) interaction partners

  1. SPAG6 binds to prestin in vivo and contributes to fix prestin biomolecules in lateral plasma membrane of outer hair cells.

  2. SPAG6 is a S-SOX5 target gene, indicating a key role for S-SOX5 in the formation and function of motile cilia.

  3. Spag6 is essential for sperm flagellar motility and that it is important for the maintenance of the structural integrity of mature sperm. The occurrence of hydrocephalus in the mutant mice also implicates Spag6 in the motility of ependymal cilia.

  4. Data describe the cloning of human and mouse Pf20 proteins that interact with Spag6 protein.

  5. Accelerated mortality from hydrocephalus and pneumonia in mice with combined deficiency of Spag6 and Spag16L reveals a functional interrelationship between the two central apparatus proteins.

  6. Spag6 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.

Sperm Associated Antigen 6 (SPAG6) Antigen Profile

Protein Summary

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Several transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SPAG6

  • sperm associated antigen 6 (SPAG6) antibody
  • sperm associated antigen 6-like (Spag6l) antibody
  • sperm associated antigen 6 (Spag6) antibody
  • sperm associated antigen 6 (spag6) antibody
  • sperm associated antigen 6 L homeolog (spag6.L) antibody
  • DKFZp459D035 antibody
  • PF16 antibody
  • repro-sa-1 antibody
  • RGD1310892 antibody
  • SPAG6 antibody
  • zgc:91805 antibody

Protein level used designations for SPAG6

axoneme central apparatus protein , protein PF16 homolog , sperm flagellar protein , sperm-associated antigen 6 , axoneme protein , sperm associated antigen 6

GENE ID SPECIES
9576 Homo sapiens
50525 Mus musculus
360747 Rattus norvegicus
420505 Gallus gallus
431757 Danio rerio
450348 Pan troglodytes
477978 Canis lupus familiaris
539424 Bos taurus
548730 Xenopus (Silurana) tropicalis
734748 Xenopus laevis
100134839 Meleagris gallopavo
100174630 Pongo abelii
100286811 Sus scrofa
100724896 Cavia porcellus
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