Sperm Associated Antigen 8 Proteins (SPAG8)

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Additionally we are shipping SPAG8 Antibodies (69) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SPAG8 26206 Q99932
SPAG8 433700  
Rat SPAG8 SPAG8 362508  
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Top SPAG8 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details

SPAG8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Sperm Associated Antigen 8 (SPAG8) Interaction Partners

Human Sperm Associated Antigen 8 (SPAG8) interaction partners

  1. Results indicate that SPAG8 acts as a regulator of ACT and plays an important role in CREM-ACT-mediated gene transcription during spermatogenesis.

  2. The antibody of this recombinant protein inhibits the mouse acrosome reaction and prmits mouse sperm-zona pellucida binding.

  3. Sperm associated antigen 8 might be involved in the regulation of cell cycle by changing the phosphorylation level of Tyr15 on CDC2 Protein Kinase.

SPAG8 Protein Profile

Protein Summary

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein encoded by this gene is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. This protein interacts with ACT (activator of CREM in testis) and may play a role in CREM (cAMP response element modulator)-ACT-mediated gene transcription during spermatogenesis. This protein may also play a role in spermatogenesis by regulating microtubule formation and cell division. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined.

Gene names and symbols associated with SPAG8

  • sperm associated antigen 8 (SPAG8)
  • sperm associated antigen 8 (Spag8)
  • BS-84 protein
  • HSD-1 protein
  • hSMP-1 protein
  • MH-SPAG8 protein
  • SMP1 protein
  • SPAG3 protein

Protein level used designations for SPAG8

sperm membrane protein 1 , sperm membrane protein BS-84 , sperm-associated antigen 8 , sperm associated antigen 8-like protein

GENE ID SPECIES
100067719 Equus caballus
26206 Homo sapiens
514627 Bos taurus
433700 Mus musculus
362508 Rattus norvegicus
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