Spermatogenesis Associated 13 Proteins
Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases.
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Spermatogenesis Associated 13 (SPATA13) (AA 1-652) protein (His tag) Protein
Spermatogenesis Associated 13 (SPATA13) (AA 1-656) protein (His tag) Protein
Spermatogenesis Associated 13 (SPATA13) Protein Profile
Protein Summary
Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA (By similarity). Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.
Gene names and symbols associated with SPATA13
- spermatogenesis associated 13 (SPATA13) antibody
- spermatogenesis associated 13 (Spata13) antibody
- ARHGEF29 antibody
- ASEF2 antibody
- C79050 antibody
- ESTM11 antibody
- mFLJ00298 antibody
- X83327 antibody
Protein level used designations for SPATA13
APC-stimulated guanine nucleotide exchange factor 2 , adenomatous polyposis coli stimulated exchange factor 2 , spermatogenesis-associated protein 13 , asef2
GENE ID | SPECIES |
---|---|
221178 | Homo sapiens |
219140 | Mus musculus |
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