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SPATA16 encodes a testis-specific protein that belongs to the tetratricopeptide repeat-like superfamily. Additionally we are shipping SPATA16 Antibodies (18) and and many more products for this protein.
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This study demonstrates that Spata16 is indispensable for male fertility in mice, as well as in humans.
Mutation of SPATA16 is associated with globozoospermia.
Case Report: report of a pregnancy obtained in a man with homozygous SPATA16 mutated globozoospermia.
results suggest that NYD-SP12 is involved in spermatogenesis, and that NYD-SP12-encoded protein might function in the Golgi apparatus
study demonstrated NYD-SP12 protein was involved in the formation of the acrosome during spermatogenesis
Results indicate that NYD-SP12 evolves rapidly in both the human and the chimpanzee lineages, which is likely caused by Darwinian positive selection and/or sexual selection.
consanguineous family with three affected brothers, in whom we have identified a homozygous mutation in the spermatogenesis-specific gene SPATA16. This is the first example of a nonsyndromic male infertility condition caused by an autosomal gene defect.
The point mutation in Spata16 was not essential for male fertility; however, deletion of the fourth exon of Spata16 resulted in infertile male mice due to spermiogenic arrest but not globozoospermia. This study demonstrates that Spata16 is indispensable for male fertility in mice, as well as in humans.
This gene encodes a testis-specific protein that belongs to the tetratricopeptide repeat-like superfamily. The encoded protein localizes to the Golgi apparatus and may play a role in spermatogenesis.
spermatogenesis associated 16
, spermatogenesis-associated protein 16
, testis development protein NYD-SP12
, testis-specific Golgi protein
, spermatogenesis-related protein