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May have a role in the regulation of spermatogenesis.. Additionally we are shipping SPATA2 Antibodies (47) and and many more products for this protein.
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Zebrafish spata2 is expressed at early developmental stages.
SPATA2 has been described as a previously unrecognized factor in the linear ubiquitin chain assembly complex-dependent signaling pathways that serves as an adaptor between HOIP (show RNF31 Proteins) and CYLD (show CYLD Proteins), thereby enabling recruitment of CYLD (show CYLD Proteins) to signaling complexes.
The data reveal SPATA2 as a high-affinity binding partner of CYLD (show CYLD Proteins) and HOIP (show RNF31 Proteins), and a regulatory component of linear ubiquitin chain assembly complex-mediated NF-kappaB (show NFKB1 Proteins) signaling.
this study identifies SPATA2 as an important factor in the TNF (show TNF Proteins) signaling pathway with a substantial role for the effects mediated by the cytokine.
The predicted PUB domain in the N-terminus of SPATA2 interacts with the USP domain of CYLD and SPATA2 is required for recruitment of CYLD to the TNF-alpha receptor-associated signaling complexes.
The aim of this study was to investigate whether the HCP5, TNIP1 (show TNIP1 Proteins), TNFAIP3 (show TNFAIP3 Proteins), SPATA2 and COG6 (show COG6 Proteins) genes were genetic risk factors for psoriasis in Chinese population.
PD-L1 (show CD274 Proteins) is highly expressed in tumours rather than tumour-free lymph nodes, which is closely correlated with the impairment of IFN-gamma (show IFNG Proteins) production of tumour-infiltrating T-cells.
Tumor-infiltrating NY-ESO-1 (show CTAG1B Proteins)-specific CD8 (show CD8A Proteins)+ T cells are negatively regulated by LAG-3 (show LAG3 Proteins) and PD-1 (show PDCD1 Proteins) in human ovarian cancer.
disappearance of TLD (show BMP1 Proteins) epitope reactivity from an otherwise stable EBV-specific response reflects selective loss of cognate antigen restimulation, not IL-7 (show IL7 Proteins)-dependent signals, and is immediately preceded by PD-1 (show PDCD1 Proteins) upregulation to unprecedented levels.
Our data revealed the impact of SPATA2 on male fertility and suggested that SPATA2 ensures the normal secretory function of Sertoli cells
Spata2 can regulate inflammatory response and cell death in both RIPK1 (show RIPK1 Proteins)-dependent and RIPK1 (show RIPK1 Proteins)-independent manners
May have a role in the regulation of spermatogenesis.
spermatogenesis associated protein 2
, spermatogenesis-associated protein 2
, spermatogenesis associated PD1
, spermatogenesis-associated protein PD1